{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T13:40:47Z","timestamp":1777815647522,"version":"3.51.4"},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0161_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Favism is a metabolic disease while pracaxi oil is a strong antioxidant agent. This study evaluates anti-infertility activity and assists normal male fertilization of pracaxi oil in favism-induced male rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0161_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 36 male albino rats of six equal sets were each with 6 rats; Control, Pracaxi oil (1\u202fmL), and Pracaxi oil (2\u202fmL), Favism-induced male rats-, Pracaxi oil (1\u202fmL)\u00a0+\u00a0Favism-induced male rats, and Pracaxi oil (2\u202fmL)\u00a0+\u00a0Favism-induced male rats groups. Blood parameters, liver function, serum male hormones were determined. Glucose-6-phosphate dehydrogenase, 3\u03b2-hydroxysteroid dehydrogenase, total protein, and cholesterol in testis were estimated. Sodium\/potassium-ATPase and antioxidants in the hypothalamus, testis, and sperm were assessed. Sperm count, motility, and abnormality, and sperm monoclonal proliferating antibody Ki-67 were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0161_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Favism decreased blood parameters, liver function, superoxide dismutase, glutathione, serum testosterone and dehydroepiandrosterone sulfate, sperm count and motility, sodium\/potassium-ATPase activity while increased malondialdehyde, serum follicle stimulating hormone, sex hormone binding globulin, and luteinizing hormone, glucose-6-phosphatedehydrogenase, 3\u03b2-hydroxysteroid dehydrogenase, cholesterol, total protein, sperm abnormality, the percentage of spermatogonia, 1st spermatocyte, 2nd spermatocyte, and spermatid in the testis. Furthermore, two doses of pracaxi oil to favism-induced male rats back all of aforementioned parameters to be close control values where a higher dose of pracaxi oil had an efficient impact than a lower dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0161_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pracaxi oil protects the hypothalamic-pituitary-gonad axis, and preserves sperm quality in favism-induced male rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0161","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T03:15:18Z","timestamp":1725419718000},"page":"501-510","source":"Crossref","is-referenced-by-count":1,"title":["Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-1700","authenticated-orcid":false,"given":"Khaled M.M.","family":"Koriem","sequence":"first","affiliation":[{"name":"Department of Medical Physiology , Medical Research and Clinical Studies Institute, National Research Centre , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud S.S.","family":"Arbid","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Medical Research and Clinical Studies Institute, National Research Centre , Cairo , Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"2025121209043057705_j_jcim-2024-0161_ref_001","doi-asserted-by":"crossref","unstructured":"McMillan, DC, Jollow, DJ. Favism: divicine hemotoxicity in the rat. Toxicol Sci 1999;51:310\u20136. https:\/\/doi.org\/10.1093\/toxsci\/51.2.310.","DOI":"10.1093\/toxsci\/51.2.310"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_002","unstructured":"Bicakci, Z. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (Vetch). Saudi Med J 2009;30:292\u20134."},{"key":"2025121209043057705_j_jcim-2024-0161_ref_003","unstructured":"Arese, P, Mannuzzu, L, Turrini, F. Pathophysiology of favism. Folia Haematol 1989;116:745\u201352."},{"key":"2025121209043057705_j_jcim-2024-0161_ref_004","unstructured":"Belsey, MA. The epidemiology of favism. Bull World Health Organ 1973;48:1\u201313."},{"key":"2025121209043057705_j_jcim-2024-0161_ref_005","unstructured":"Lin, JY, Ling, KFL, Studies on Favism I. Isolation of an active principle from faba beans (Vicia faba L.). J Formos Med Assoc 1962;61:484\u20138."},{"key":"2025121209043057705_j_jcim-2024-0161_ref_006","doi-asserted-by":"crossref","unstructured":"Albano, E, Tomasi, A, Mannuzzu, L, Arese, P. Detection of free radical intermediate from divicine of Vicia faba. Biochem Pharmacol 1984;33:1701\u20134. https:\/\/doi.org\/10.1016\/0006-2952(84)90299-5.","DOI":"10.1016\/0006-2952(84)90299-5"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_007","unstructured":"Marquardt, RR. Vicine, convicine and their role aglycnes-divine and isouramil. In: Cheeke, P, editor.,Toxicants of plant origin, 2nd ed. Boca Raton, F. l, New York, USA: CRC Press; 1989:614\u201323 pp."},{"key":"2025121209043057705_j_jcim-2024-0161_ref_008","doi-asserted-by":"crossref","unstructured":"Hegazy, MI, Marquardt, RR. Metabolism of vicine and convicine in rat tissues: absorption and excretion patterns and site of hydrolysis. J Sci Food Agric 1984;35:139\u201346. https:\/\/doi.org\/10.1002\/jsfa.2740350204.","DOI":"10.1002\/jsfa.2740350204"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_009","doi-asserted-by":"crossref","unstructured":"Nobre Lamar\u00e3o, ML, Ferreira, LMMC, Gyles Lynch, D, Morais, LRB, Silva-J\u00fanior, JOC, Ribeiro-Costa, RM. Pentaclethra macroloba: a review of the biological, pharmacological, phytochemical, cosmetic, nutritional and biofuel potential of this amazonian plant. Plants (Basel) 2023;12:1330. https:\/\/doi.org\/10.3390\/plants12061330.","DOI":"10.3390\/plants12061330"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_010","doi-asserted-by":"crossref","unstructured":"Eberhart, BS, Komiyama, CM, Burbarelli, MFC, Castilho Heiss, VAR, Garcia, RG, Borges, R, et al.. Characterization and subchronic oral toxicity of Pentaclethra macroloba (pracaxi) oil in Rattus norvegicus (lin. Wistar). 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Indian J Clin Biochem 2017;32:446\u201352. https:\/\/doi.org\/10.1007\/s12291-016-0623-4.","DOI":"10.1007\/s12291-016-0623-4"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_035","doi-asserted-by":"crossref","unstructured":"Koriem, KMM, Arbid, MSS. Vitamin E ameliorates disturbances in testosterone pathway and sperm quality of male rats induced by the glycosides vicine and convicine of Vicia faba. Nutr Food Sci 2022;52:61\u201374. https:\/\/doi.org\/10.1108\/nfs-02-2021-0053.","DOI":"10.1108\/NFS-02-2021-0053"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_036","doi-asserted-by":"crossref","unstructured":"Koriem, KMM, Arbid, MS. Evaluating of \u03b2-carotene role in ameliorating of favism-induced disturbances in blood and testis. J Complement Integr Med 2018;15: 20170164, https:\/\/doi.org\/10.1515\/jcim-2017-0164.","DOI":"10.1515\/jcim-2017-0164"},{"key":"2025121209043057705_j_jcim-2024-0161_ref_037","unstructured":"Guyton, AC, Hall, JE. 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