{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:57:42Z","timestamp":1793836662028,"version":"4.6.1"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0290_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Natural flora historically has played a substantial part in drug development since they serve as active ingredients in medications and templates for the synthesis of novel pharmaceuticals.\n                      <jats:italic>Emilia sonchifolia<\/jats:italic>\n                      is a conventionally utilised therapeutic flora in Indian pharmacopoeia. Therefore, the current study is intended to separate, structurally describe and analyse the anti-pancreatic cancer potential of isolated natural bio-constituents from\n                      <jats:italic>E.\u00a0sonchifolia<\/jats:italic>\n                      (L.) DC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0290_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      n-Hexane extract using chromatographic techniques and structurally characterize them using spectroscopic techniques. Further,\n                      <jats:italic>in silico<\/jats:italic>\n                      molecular docking method was employed to investigate the bioactivity of the isolated compound against Aurora 2 Kinase (pancreatic cancer target protein).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0290_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A mixture of stigmasterol with straight-chain monounsaturated alcohol (C\n                      <jats:sub>49<\/jats:sub>\n                      H\n                      <jats:sub>86<\/jats:sub>\n                      O) was isolated and identified from the aerial parts of\n                      <jats:italic>E.\u00a0sonchifolia<\/jats:italic>\n                      using chromatographic techniques. The docking results showed that the isolated natural compound of stigmasterol with straight-chain monounsaturated alcohol has good docking results compared with Food and Drug Administration-permitted medicine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0290_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the outcomes, it can be concluded that the stigmasterol with straight-chain monounsaturated alcohol may act as a novel inhibitor for Aurora 2 Kinase. In the future, it may lead to the development of drugs targeting Aurora 2 Kinase for the effective treatment of pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0290","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T03:54:56Z","timestamp":1734407696000},"page":"165-172","source":"Crossref","is-referenced-by-count":19,"title":["Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of\n                    <i>Emilia sonchifolia<\/i>\n                    (L.) DC against the pancreatic cancer target Aurora 2 Kinase"],"prefix":"10.1515","volume":"22","author":[{"given":"Pratibha","family":"Prabhakaran","sequence":"first","affiliation":[{"name":"Center for Wireless Networks Applications (WNA) , Amrita Vishwa Vidyapeetham , Kollam , India"},{"name":"Department of Biochemistry , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chella Perumal","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology, Faculty of Science , Chulalongkorn University , Bangkok , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abirami","family":"Shanmugam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Saveetha Medical College and Hospital , Saveetha Institute of Medical and Technical Sciences (SIMATS) , Chennai , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhu","family":"Damodharan","sequence":"additional","affiliation":[{"name":"Centre for Bioinformatics, Department of Biotechnology , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshini","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhivya","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathi Muthaiyan","family":"Ahalliya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-1424","authenticated-orcid":false,"given":"Gopalakrishnan","family":"Velliyur Kanniappan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Karpagam Academy of Higher Education , Coimbatore , Tamil Nadu , India"},{"name":"Centre for Global Health Research, Saveetha Medical College and Hospital , Saveetha Institute of Medical and Technical Sciences (SIMATS) , Chennai , Tamil Nadu , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"2025121209061515471_j_jcim-2024-0290_ref_001","doi-asserted-by":"crossref","unstructured":"Zhao, J, Li, X, Sun, J, Song, M, Wang, L, Yuan, S, et al.. 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