{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562754,"version":"4.1.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0380_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Drug-induced hepatotoxicity, particularly from ethanol and acetaminophen (APAP), is a pressing global health challenge. This damage arises from oxidative stress and inflammation, manifesting as elevated liver enzymes and structural liver alterations. Resveratrol and silymarin, recognized for their antioxidant and anti-inflammatory properties, offer potential hepatoprotective benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0380_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study investigated the hepatoprotective efficacy of resveratrol and silymarin, alone and in combination, in a rat model of ethanol- and APAP-induced liver injury. Thirty Wistar rats were divided into five groups: control, ethanol-APAP, ethanol-APAP-resveratrol, ethanol-APAP-silymarin, and ethanol-APAP-resveratrol-silymarin. Treatments were administered orally for 10\u00a0days. Serum ALT and AST levels were assessed, and liver tissues underwent histological evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0380_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ethanol and APAP administration significantly elevated ALT and AST levels, alongside severe liver structural disruptions. Treatment with resveratrol or silymarin alone normalized enzyme levels and improved liver histology. Notably, the combined resveratrol-silymarin treatment exhibited greater reductions in ALT and AST levels and superior restoration of liver architecture compared to either treatment alone, indicating a synergistic hepatoprotective effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0380_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Resveratrol and silymarin effectively counteract ethanol- and APAP-induced hepatotoxicity by mitigating oxidative stress and inflammation. Their combined use demonstrates a synergistic benefit, as evidenced by enhanced biochemical and histological improvements. These findings support the potential therapeutic role of these natural agents in managing drug-induced liver injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0380","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:41:07Z","timestamp":1735184467000},"page":"87-93","source":"Crossref","is-referenced-by-count":3,"title":["A potential therapeutic role of resveratrol in mitigating hepatotoxicity induced by paracetamol and alcohol"],"prefix":"10.1515","volume":"22","author":[{"given":"Mahra Ali","family":"Almazrouei","sequence":"first","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Paul","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Anatomy , RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruaa Faris","family":"Tawfeeq","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Khizarali","family":"Hashmi","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusur Abbas","family":"Mahmood","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maitha Rashed","family":"Abdulla","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashayer Abdulla","family":"Alshamsi","sequence":"additional","affiliation":[{"name":"RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunatha","family":"Goud","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anatomy , RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University , Ras Al Khaimah , United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"2025121209061508557_j_jcim-2024-0380_ref_001","unstructured":"Arab, Z, Salmani, H, Marefati, N, Beheshti, F, Anaeigoudari, A, Shakeri, F, et al.. 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