{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:12:24Z","timestamp":1770041544802,"version":"3.49.0"},"reference-count":47,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2024-0450_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Neurodegeneration continues to drive conditions of progressive cognitive decline from amnesia to severe dementia in different age groups. Despite, the availability of standard drugs, the need for multi-targeted interventions with no side-effects remains to be explored. Hence, this study evaluates the neuroprotective effects of\n                      <jats:italic>Aframomum melegueta<\/jats:italic>\n                      and\n                      <jats:italic>Aframomum danielli<\/jats:italic>\n                      seeds dietary inclusion on\u00a0neurocognitive decline in scopolamine-administered male\u00a0rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0450_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven groups of experimental rats were studied for 14\u00a0days: normal rats (group 1), untreated scopolamine-administered rats (group 2), scopolamine-administered rats treated with donepezil (group 3), scopolamine-administered rats treated with dietary inclusions of 4 and 8\u202f%\n                      <jats:italic>A.\u00a0melegueta<\/jats:italic>\n                      (groups 4 and 5 respectively), and 4 and 8\u202f%\n                      <jats:italic>A.\u00a0danielli<\/jats:italic>\n                      (groups 6 and 7 respectively). Rats were trained with Morris water maze, pre-treated with the diets, and administered (I. P) scopolamine (3\u202fmg\/kg body weight from days 12\u201314). Memory functionality was evaluated using the maze test and hippocampal and cortical brain regions were analyzed biochemically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0450_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Scopolamine administration impaired working memory, evidenced by increased escape latency and activities of neurodegenerative biomarkers in untreated rats.\n                      <jats:italic>A.\u00a0melegueta<\/jats:italic>\n                      and\n                      <jats:italic>A.\u00a0danielli<\/jats:italic>\n                      dietary inclusions significantly reduced escape latency, improved working memory, and restored key biomarkers, including acetylcholinesterase, butyrylcholinesterase, monoamine oxidase, and reactive oxygen species. Treated rats also exhibited elevated total thiol levels, and improved anti-inflammatory markers (IL-10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2024-0450_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both\n                      <jats:italic>A.\u00a0melegueta<\/jats:italic>\n                      and\n                      <jats:italic>A.\u00a0danielli<\/jats:italic>\n                      seeds showed\u00a0improved neuroprotective effect in the brain of scopolamine-induced amnesia rats highlighting significant intervention against cognition. However,\n                      <jats:italic>A.\u00a0melegueta<\/jats:italic>\n                      showed greater neuroprotective efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2024-0450","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T13:13:47Z","timestamp":1751462027000},"page":"427-437","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotective effects of dietary inclusions of alligator pepper (\n                    <i>Aframomum melegueta<\/i>\n                    ) and bastard melegueta (\n                    <i>Aframomum danielli<\/i>\n                    ) seeds on scopolamine-induced amnesia in rats"],"prefix":"10.1515","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-0472","authenticated-orcid":false,"given":"Odunayo M.","family":"Agunloye","sequence":"first","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther A.","family":"Olawuyi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Federal University of Technology , Akure , Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"2025121209060007080_j_jcim-2024-0450_ref_001","doi-asserted-by":"crossref","unstructured":"Liu, W, Rabinovich, A, Nash, Y, Frenkel, D, Wang, Y, Youdim, MB, et al.. 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