{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:08:55Z","timestamp":1793660935869,"version":"4.5.1"},"reference-count":113,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2025-0082_abs_001\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The use of medications for the treatment of various diseases often results in kidney damage. Apitherapy is a natural therapeutic tool with potential utility for this purpose. This narrative review analyzes and summarizes the scientific evidence on the use of apitherapy in drug-induced kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0082_abs_002\">\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This review summarizes and analyzes recent advances in drug-induced kidney disease and explores, based on the available scientific evidence, how apitherapy can modify these mechanisms and be utilized for prevention and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0082_abs_003\">\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Apitherapy (the complementary and integrative use of beehive products) is a potentially useful therapeutic system for the treatment of various diseases. This review examines the preclinical and clinical evidence available regarding its potential use in drug-induced kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0082_abs_004\">\n                    <jats:title>Outlook<\/jats:title>\n                    <jats:p>Apitherapy has effects on various pathophysiological mechanisms of drug-induced kidney disease, including oxidative stress, inflammation, decreased renal blood flow, glomerular damage, increased membrane permeability, activity of the renin-angiotensin-aldosterone axis, mitochondrial dysfunction, and apoptosis. Further studies in humans are needed to evaluate its efficacy in the clinical setting, but the available evidence is promising.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2025-0082","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T22:18:46Z","timestamp":1743718726000},"page":"33-42","source":"Crossref","is-referenced-by-count":2,"title":["Apitherapy for drug-induced kidney disease: a narrative review on its mechanisms"],"prefix":"10.1515","volume":"23","author":[{"given":"Andr\u00e9s","family":"Jagua-Gualdr\u00f3n","sequence":"first","affiliation":[{"name":"National University of Colombia , Bogot\u00e1 D.C. , Colombia"},{"name":"International Institute for Complementary and Alternative Medicine-IIMAN , Bogot\u00e1 D.C. , Colombia"},{"name":"International College of Apitherapy , Bogot\u00e1 D.C. , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai Andr\u00e9s","family":"Garc\u00eda-Reyes","sequence":"additional","affiliation":[{"name":"National University of Colombia , Bogot\u00e1 D.C. , Colombia"},{"name":"International Institute for Complementary and Alternative Medicine-IIMAN , Bogot\u00e1 D.C. , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holman Leonardo","family":"Africano-Lopez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Universitaria de Ciencias de la Salud, Sociedad de Cirug\u00eda de Bogot\u00e1, Hospital San Jos\u00e9 Sede Centro , Bogot\u00e1 D.C. , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"2026051215162682027_j_jcim-2025-0082_ref_001","doi-asserted-by":"crossref","unstructured":"Majagi, SI. 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