{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T11:56:46Z","timestamp":1765540606720,"version":"3.48.0"},"reference-count":58,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2025-0101_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Ulcerative colitis, with a complex and poorly understood aetiology, is a chronic inflammatory disease of the colon. Current therapies present many side effects and lack efficiency. This study aimed to assess the healing properties of aqueous and ethanolic extracts from the roots of\n                      <jats:italic>Dracaena arborea<\/jats:italic>\n                      on ulcerative colitis induced in\u00a0rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0101_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Acetic acid (4\u202f%) was injected (intrarectal) to induce colitis. Prednisolone (20\u202fmg\/kg), aqueous (500\u202fmg\/kg) and ethanolic (100\u202fmg\/kg) extracts were administered orally. Clinical parameters were measured through stool consistency, relative body mass, mass-to-length ratio, macroscopic alterations of the colon, and serum and haematological parameters. Oxidative stress markers (in both serum and tissue) and anti-inflammatory parameters were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0101_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that both extracts significantly reduced diarrhea severity, ulcer scores, and prevented the reduction in the colon mass\/length ratio. The aqueous and ethanolic extracts significantly increased red blood cell count and haematocrit percentage, as well significantly reducing white blood cell, lymphocyte, monocyte, and granulocyte counts. Regarding oxidative stress markers, in both serum and tissue, the extracts significantly reduced MDA concentrations while increasing GSH concentrations, SOD and catalase activities. The aqueous and ethanolic extracts also significantly reduced NO concentrations and MPO activity. Only the ethanolic extract significantly inhibited TNF-\u03b1, IL-6 and IL-1\u03b2 production. Additionally, both extracts exhibited reparative effects on intestinal epithelium by activating tissue regeneration mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0101_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings suggest that\n                      <jats:italic>D.\u00a0arborea<\/jats:italic>\n                      possessed anti-colitis effects in acetic acid-induced ulcerative colitis in\u00a0rats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2025-0101","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:29:37Z","timestamp":1750145377000},"page":"438-450","source":"Crossref","is-referenced-by-count":0,"title":["Effect of aqueous and ethanolic extracts of\n                    <i>Dracaena arborea<\/i>\n                    (Dracaenaceae) on acetic acid-induced colitis in rats"],"prefix":"10.1515","volume":"22","author":[{"given":"Liliane Mireille","family":"Tchoumba Tchoumi","sequence":"first","affiliation":[{"name":"Department of Chemistry-Biology, Faculty of Sciences , University of Bertoua , Bertoua , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Yousseu","family":"Nana","sequence":"additional","affiliation":[{"name":"Department of Biology of Animal Organisms, Laboratory of Biology and Physiology of Animal Organisms, Faculty of Science , The University of Douala Cameroon , Douala , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzal Eric","family":"Tsafack","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Flore Nguemnang","family":"Djuichou","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvine Dorelle","family":"Djomo Tchokote","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile Evodie","family":"Tonpouwo","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry Parfait","family":"Elomo Assomo","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Mbiantcha","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Ateufack","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Laboratory of Animal Physiology and Phytopharmacology, Faculty of Science , 107819 University of Dschang , Dschang , Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"2025121209150696993_j_jcim-2025-0101_ref_001","doi-asserted-by":"crossref","unstructured":"Kehinde, PO, Rufus, OA, Olumide, SA, Modinat, AA, Quadri, KA. 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