{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:11:27Z","timestamp":1778602287132,"version":"3.51.4"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2025-0221_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Investigate the cytoprotective, anti-apoptotic, and anti-inflammatory effects of two different doses of\n                      <jats:italic>Echinacea purpurea<\/jats:italic>\n                      extract against iron overload-induced bone marrow suppression and spleen cell damage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0221_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      50 male rats divided into five groups: (I)\u00a0received a 0.2\u202fmL intraperitoneal saline injection, 1\u202fmL oral gavage daily. (II) intraperitoneally injected (200\u202fmg\/kg iron); daily oral gavage 1\u202fmL saline solution. (III) intraperitoneally injected (200\u202fmg\/kg iron),\n                      <jats:italic>E.\u00a0purpurea<\/jats:italic>\n                      (100\u202fmg\/kg\/day) orally administered. (IV) intraperitoneally injected (200\u202fmg\/kg iron),\n                      <jats:italic>E.\u00a0purpurea<\/jats:italic>\n                      (200\u202fmg\/kg\/day) orally administered. (V)\u00a0intraperitoneally injected (200\u202fmg\/kg iron), orally administered vitamin E (200\u202fmg\/kg\/day). Injections administered every 3\u00a0days; treatment for 4\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0221_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Echinacea Purpurea<\/jats:italic>\n                      significantly reduces monocyte cell count, Akt1, Foxo-1, and NF\u03baB; significantly elevates lymphocyte cell count; and highly significantly elevates Sirt-3 gene expression. It substantially reduces the levels of IL-6, MCP-1, and\u00a0FasL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0221_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Echinacea Purpurea<\/jats:italic>\n                      exhibits anti-inflammatory and immunomodulatory effects, and it reduces bone marrow suppression and spleen cell injury caused by iron overload.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2025-0221","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:46:17Z","timestamp":1769154377000},"page":"163-172","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED ARTICLE: Evaluation of the protective effect of the\n                    <i>Echinacea Purpurea<\/i>\n                    against apoptosis and inflammation induced by overdose of iron dextran on the hematopoietic system"],"prefix":"10.1515","volume":"23","author":[{"given":"Doaa Kahim","family":"Abdul Ridha","sequence":"first","affiliation":[{"name":"Ministry of Health, The National Centre of Drug Control and Research (NCDCR) , Baghdad , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Faris","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology , College of Pharmacy, University of Baghdad , Baghdad , Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"2026051215162688618_j_jcim-2025-0221_ref_001","doi-asserted-by":"crossref","unstructured":"Zhang, L, Dai, X, Wang, L, Cai, J, Shen, J, Shen, Y, et al.. 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