{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:02:43Z","timestamp":1791475363569,"version":"4.3.4"},"reference-count":53,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2025-0256_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Malaria and type 2 diabetes mellitus (T2DM) often coexist in sub-Saharan Africa, worsening disease burden and complicating treatment. This study evaluated the protective effects of\n                      <jats:italic>Alstonia boonei<\/jats:italic>\n                      stem bark aqueous extract on\n                      <jats:italic>Plasmodium berghei<\/jats:italic>\n                      -infected diabetic mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0256_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male mice were divided into five groups: normal control, untreated infected\/diabetic, chloroquine\u2013metformin treated, and extract-treated groups (40 and 80 mg\/kg body weight). Fasting blood glucose, parasitemia, \u03b1-amylase, \u03b1-glucosidase, antioxidant enzymes, inflammatory markers, and hematological indices were assessed following treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0256_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Untreated infected\/diabetic mice exhibited significant hyperglycemia, elevated parasitemia, oxidative stress, anemia, and dysregulated inflammatory responses compared with controls. Administration of\n                      <jats:italic>A. boonei<\/jats:italic>\n                      extract produced a dose-dependent reduction in fasting blood glucose and parasitemia, alongside inhibition of \u03b1-amylase and \u03b1-glucosidase. The extract enhanced antioxidant status (SOD, catalase, GSH), restored red blood cell count, hemoglobin, and packed cell volume, reduced C-reactive protein levels, and elevated interleukin-10. These effects were more pronounced at 80 mg\/kg and comparable to the standard drug group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0256_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>A. boonei<\/jats:italic>\n                      stem bark aqueous extract demonstrated antihyperglycemic, antiplasmodial, antioxidant, and anti-inflammatory effects in malaria\u2013diabetes comorbidity. The findings support its potential as a natural therapeutic agent for managing malaria and diabetes co-occurrence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2025-0256","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:47:26Z","timestamp":1758872846000},"page":"623-632","source":"Crossref","is-referenced-by-count":1,"title":["<i>Alstonia boonei<\/i>\n                    stem bark aqueous extract ameliorates elevated parasitemia levels, normalises blood glucose, modulates inflammatory biomarkers and enhances antioxidant status in\n                    <i>Plasmodium berghei-infected<\/i>\n                    \/diabetic mice"],"prefix":"10.1515","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-0472","authenticated-orcid":false,"given":"Odunayo Michael","family":"Agunloye","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Functional Foods and Nutraceuticals Unit , Federal University of Technology , Akure , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi Francis","family":"Akintoye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Functional Foods and Nutraceuticals Unit , Federal University of Technology , Akure , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Functional Foods and Nutraceuticals Unit , Federal University of Technology , Akure , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"2025123009332446779_j_jcim-2025-0256_ref_001","doi-asserted-by":"crossref","unstructured":"Lopez, AD, Mathers, CD, Ezzati, M, Jamison, DT, Murray, CJ. 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