{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:11:31Z","timestamp":1778602291654,"version":"3.51.4"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2025-0288_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the effects of chronic oral administration of commercial guava (Psidium guajava L.) leaf extract on biochemical markers and liver histology in a model of metabolic syndrome in\u00a0rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0288_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty-five Wistar rats were assigned to five independent groups (n=7 per group): the control group (CG), which received a diet with standard rodent food (Nutri-Cubos\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) and water\n                      <jats:italic>ad libitum<\/jats:italic>\n                      ; the metabolic syndrome group (MS), MS +\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>guajava<\/jats:italic>\n                      (Pg) low-dose (PgL; 100\u202fmg\/kg), MS + Pg medium-dose (PgM; 200\u202fmg\/kg), and MS +\n                      <jats:italic>Pg<\/jats:italic>\n                      high-dose (PgH; 300\u202fmg\/kg) groups. MS was induced with a rich diet of fat and carbohydrates, in addition to the intake of a 30\u202f% sucrose solution\n                      <jats:italic>ad libitum<\/jats:italic>\n                      for 14\u00a0weeks. From week 15 onward, guava leaf extract or vehicle was administered orally every 24\u202fh for 30 consecutive days without changing the experimental diet. At the end of the treatment, biochemical tests, liver histopathological analysis and adipose tissue analysis were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0288_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MS group presented levels above the reference ranges for biochemical tests, weight gain, waist circumference gain, arterial hypertension, atypical liver cells and aberrant appearance in adipose rat tissue. The PgM and PgH groups presented opposite effects of MS on biochemical parameters, such as increased blood pressure and liver damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2025-0288_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chronic treatment with Pg leaf extract attenuated MS in Wistar rats, restoring the levels of biochemical parameters and exerting hepatoprotective effects. These findings suggest that guajava extract could be used in the development of therapeutic agents to improve the biochemical and histological alterations induced by\u00a0MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2025-0288","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:56:00Z","timestamp":1765950960000},"page":"150-162","source":"Crossref","is-referenced-by-count":0,"title":["Guava (Psidium guajava L.) leaf extract improves the prognosis of nonalcoholic fatty liver and biochemical parameters in rats with metabolic syndrome"],"prefix":"10.1515","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-2202","authenticated-orcid":false,"given":"Eduardo","family":"Rivadeneyra-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica , Universidad Veracruzana , Xalapa , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-470X","authenticated-orcid":false,"given":"Socorro","family":"Herrera-Meza","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Psicol\u00f3gicas, Universidad Veracruzana , Xalapa , Veracruz , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda F.","family":"Almanza- Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica , Universidad Veracruzana , Xalapa , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-7642","authenticated-orcid":false,"given":"H\u00e9ctor G.","family":"Acosta-Mesa","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Inteligencia Artificial, Universidad Veracruzana , Xalapa , Veracruz , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3658-4808","authenticated-orcid":false,"given":"Daniel","family":"Hern\u00e1ndez-Baltazar","sequence":"additional","affiliation":[{"name":"Instituto de Neuroetolog\u00eda, Universidad Veracruzana , Xalapa , Veracruz , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-1389","authenticated-orcid":false,"given":"Isaac","family":"Zamora-Bello","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Farmac\u00e9utica Biol\u00f3gica , Universidad Veracruzana , Xalapa , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-103X","authenticated-orcid":false,"given":"Juan F.","family":"Rodr\u00edguez-Landa","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda, Instituto de Neuroetolog\u00eda, Universidad Veracruzana , Xalapa , Veracruz , Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2026051215162680322_j_jcim-2025-0288_ref_001","doi-asserted-by":"crossref","unstructured":"Jani\u0107, M, Jane\u017e, A, El-Tanani, M, Rizzo, M. 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