{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:45Z","timestamp":1791395505351,"version":"4.3.3"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2026-0080_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the antidepressant-like effects of combined nutritional supplementation with omega-3 fatty acids, vitamin D, and biotin, alone and in combination with half-dose fluoxetine, in a Chronic Unpredictable Mild Stress (CUMS) model of depression in\u00a0rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0080_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty Sprague\u2013Dawley rats were divided into five groups: control, disease control, fluoxetine-treated (5\u202fmg\/kg), nutrient combination (omega-3 fatty acids, vitamin D, and biotin), and nutrient combination with half-dose fluoxetine (2.5\u202fmg\/kg). Depression was induced using the CUMS model for four weeks. Behavioral assessments were performed using the sucrose preference test and elevated plus maze (EPM). Biochemical parameters including malondialdehyde (MDA), superoxide dismutase (SOD), catalase, thiol levels, and brain-derived neurotrophic factor (BDNF) were estimated. Histopathological examination of hippocampus and dentate gyrus was conducted. Data were analyzed using one-way analysis of variance followed by Tukey\u2019s post hoc\u00a0test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0080_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The nutrient combination and half-dose fluoxetine with nutrient combination groups showed significant behavioral improvement vs. the disease control group, with higher sucrose preference and greater open-arm time in the EPM. Catalase activity was significantly higher in the nutrient combination group (2.50\u00a0\u00b1\u00a00.71 vs. 0.16\u00a0\u00b1\u00a00.03\u202fpmol\/min), while the half-dose fluoxetine with nutrient combination group demonstrated significantly higher SOD (2.11\u00a0\u00b1\u00a00.03 vs. 0.07\u00a0\u00b1\u00a00.01\u202fmilliunit\/mg protein) and lower MDA (1.35\u00a0\u00b1\u00a00.10 vs. 4.70\u00a0\u00b1\u00a00.09\u202f\u03bcM\/L) compared with disease control. Both these groups showed increased healthy neurons in the hippocampus and dentate gyrus in histopathological analysis, suggesting neuroprotection and neuronal regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0080_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combined nutrient supplementation demonstrated significant antidepressant-like effects compared to fluoxetine alone, indicating potential adjunctive benefits requiring further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2026-0080","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:11:55Z","timestamp":1782843115000},"page":"495-505","source":"Crossref","is-referenced-by-count":0,"title":["Effects of combined nutritional supplementation with biotin, omega-3 polyunsaturated fatty acids and vitamin D in depression: a preclinical study"],"prefix":"10.1515","volume":"23","author":[{"given":"Harsha","family":"Gautam","sequence":"first","affiliation":[{"name":"Department of Pharmacology , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0486-9331","authenticated-orcid":false,"given":"Amrita","family":"Parida","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-1427","authenticated-orcid":false,"given":"Shreya","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4085-8982","authenticated-orcid":false,"given":"Siddhanth","family":"Rangineni","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-9661","authenticated-orcid":false,"given":"Vijetha Shenoy","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Biochemistry , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-0718","authenticated-orcid":false,"given":"Mohandas Rao Kappettu","family":"Gadahad","sequence":"additional","affiliation":[{"name":"Division of Anatomy, Department of Basic Medical Sciences , Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya R.","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Kasturba Medical College, Manipal Academy of Higher Education , Manipal , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juwairiya","family":"Sayyad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology , Yenepoya Medical College , Deralakatte , Mangalore , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"2026100716595865065_j_jcim-2026-0080_ref_001","unstructured":"World Health Organization. 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Washington (DC): National Academies Press (US); 2009 [cited 2025 Mar 19]. Available at: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK215117\/."},{"key":"2026100716595865065_j_jcim-2026-0080_ref_004","doi-asserted-by":"crossref","unstructured":"Correia, AS, Cardoso, A, Vale, N. Oxidative stress in depression: the link with the stress response, neuroinflammation, serotonin, neurogenesis and synaptic plasticity. Antioxidants (Basel) 2023;12:470. https:\/\/doi.org\/10.3390\/antiox12020470.","DOI":"10.3390\/antiox12020470"},{"key":"2026100716595865065_j_jcim-2026-0080_ref_005","doi-asserted-by":"crossref","unstructured":"Ferguson, JM. SSRI antidepressant medications: adverse effects and tolerability. Prim Care Companion J Clin Psychiatry 2001;3:22\u20137. https:\/\/doi.org\/10.4088\/pcc.v03n0105.","DOI":"10.4088\/PCC.v03n0105"},{"key":"2026100716595865065_j_jcim-2026-0080_ref_006","doi-asserted-by":"crossref","unstructured":"Du, J, Zhu, M, Bao, H, Li, B, Dong, Y, Xiao, C, et al.. 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