{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T06:55:03Z","timestamp":1790578503831,"version":"4.1.0"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jcim-2026-0131_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      This study aimed to evaluate its metabolic effects of\n                      <jats:italic>Cissus sicyoides<\/jats:italic>\n                      L. aqueous extract treatment in Wistar rats subjected to an intergenerational obesity\u00a0model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0131_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male offspring (F1 generation) of female rats with monosodium glutamate-induced obesity (F0 generation) were classified as non-obese and obese in adulthood based on the Lee index, and were treated with an aqueous extract of\n                      <jats:italic>C.\u00a0sicyoides<\/jats:italic>\n                      (8.91\u202fmg\/kg) for 28\u00a0days. Phenolic compounds in the extract were identified by HPLC-DAD-ESI-MSn. Metabolic parameters, including body mass, food and water intake, biochemical markers, and renal function, were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0131_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment with\n                      <jats:italic>C.\u00a0sicyoides<\/jats:italic>\n                      extract reduced glycemia and non-HDL cholesterol levels in obese rats. Additionally, decreases in body mass, Lee index, and relative liver weight were observed. A total of 11 phenolic compounds were identified, including flavonoids and phenolic\u00a0acids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0131_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The extract of\n                      <jats:italic>C.\u00a0sicyoides<\/jats:italic>\n                      in an intergenerational obesity rat model showed reductions in glycemia, non-HDL cholesterol, and body weight, as well as modulation of hepatic parameters, suggesting its use as an adjuvant strategy in metabolic disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2026-0131","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:56:14Z","timestamp":1790574974000},"source":"Crossref","is-referenced-by-count":0,"title":["Extract of\n                    <i>Cissus sicyoides<\/i>\n                    L. modulates metabolic biomarkers in an intergenerational obesity model"],"prefix":"10.1515","author":[{"given":"Andre","family":"Cantarelli Vilela","sequence":"first","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Vitor Alves Damacena","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tizzo Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Becker Pertuzatti Konda","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleber","family":"Eduardo de Campos","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Physiology and Reproductive Toxicology , Institute of Biological and Health Sciences, Federal University of Mato Grosso , Barra do Gar\u00e7as , MT , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"2026092805560451514_j_jcim-2026-0131_ref_001","unstructured":"World Obesity Federation. 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