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SA-PS was quality-controlled for purity, endotoxin, monosaccharide profile, and molecular weight. Efficacy and interaction were assessed in murine nociception, pyrexia, and edema models using fixed-ratio Chou-Talalay analysis and inflammatory biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0142_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combination showed synergy mainly in inflammation-dominant endpoints, including formalin phase II and carrageenan edema AUC, with CI values of 0.60\u20130.78 and DRI values of 1.30\u20132.10 at Fa=0.50\u20130.75. Responses were accompanied by lower IL-6\/PGE\n                      <jats:sub>2<\/jats:sub>\n                      and MPO\/COX-2-linked readouts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jcim-2026-0142_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support a processing-informed natural health product framework with preclinical dose-sparing relevance for inflammation-dominant pain, fever, and edema, warranting further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jcim-2026-0142","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:55:53Z","timestamp":1791449753000},"source":"Crossref","is-referenced-by-count":0,"title":["Standardized black\n                    <i>Allium chinense<\/i>\n                    G.Don and\n                    <i>Sonneratia apetala<\/i>\n                    Banks polysaccharide as a natural health product strategy for pain, fever, and inflammation"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-8545","authenticated-orcid":false,"given":"Thi Phuong Nhung","family":"Tran","sequence":"first","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huyen Trang","family":"Luu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Quan","family":"Bui","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Phung Nghi","family":"Dang","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Bao Ngoc","family":"Van","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City , Ho Chi Minh City , Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2026100808554634274_j_jcim-2026-0142_ref_001","doi-asserted-by":"crossref","unstructured":"Duarte, D, Vale, N. 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