{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:45:50Z","timestamp":1791960350971,"version":"4.3.4"},"reference-count":90,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Uterine fibroids (UF) are among the most common benign tumors in women, yet their genetic underpinnings remain largely unexplored. Given the importance of genetic predisposition and the significance of GWAS-identified loci in UF, we aimed to investigate how family history of UF influences the association between these loci and the disease risk. DNA samples from 241 women with a family history of UF and 947 women without were genotyped for seven GWAS SNPs using probe-based PCR. In patients without a family history of UF, rs547025\n                    <jats:italic>SIRT3<\/jats:italic>\n                    was associated with a reduced risk (effect allele C, OR = 0.59, 95\u202f% CI = 0.41\u20130.83,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002). Conversely, rs7986407\n                    <jats:italic>FOXO1<\/jats:italic>\n                    was linked to an increased risk of UF in those with a family history (effect allele G, OR = 1.94, 95\u202f% CI = 1.03\u20133.68,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03). The most significant gene-environment interactions in patients with a family history were observed with pelvic inflammatory disease and GWAS SNPs, while in those without a family history, interactions additionally involved medical abortions. Our bioinformatic analysis uncovered the SNPs\u2019 molecular mechanisms, contributing to UF development.\n                  <\/jats:p>","DOI":"10.1515\/jib-2024-0045","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:56:10Z","timestamp":1791957370000},"source":"Crossref","is-referenced-by-count":0,"title":["Family history of\u00a0uterine fibroids significantly modifies associations of\u00a0GWAS loci with\u00a0the disease risk: molecular-genetics and\u00a0bioinformatic analysis"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7282-6012","authenticated-orcid":false,"given":"Liubov","family":"Gliantseva","sequence":"first","affiliation":[{"name":"Laboratory of Genomic Research , Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University , 305041 Kursk , Russia"},{"name":"Department of Obstetrics and Gynecology , Institute of Continuing Education, Kursk State Medical University , 305041 Kursk , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0652-2219","authenticated-orcid":false,"given":"Ksenia","family":"Kobzeva","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Research , Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University , 305041 Kursk , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6900-6944","authenticated-orcid":false,"given":"Vladislav","family":"Kuz\u2019minov","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Research , Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University , 305041 Kursk , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3333-0623","authenticated-orcid":false,"given":"Olga","family":"Bushueva","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Research , Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University , 305041 Kursk , Russia"},{"name":"Department of Biology , Medical Genetics and Ecology, Kursk State Medical University , 305041 Kursk , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101405560755099_j_jib-2024-0045_ref_001","doi-asserted-by":"crossref","unstructured":"Yang, Q, Ciebiera, M, Bariani, MV, Ali, M, Elkafas, H, Boyer, TG, et al.. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr Rev 2022;43:678\u2013719. https:\/\/doi.org\/10.1210\/endrev\/bnab039.","DOI":"10.1210\/endrev\/bnab039"},{"key":"2026101405560755099_j_jib-2024-0045_ref_002","doi-asserted-by":"crossref","unstructured":"Giuliani, E, As-Sanie, S, Marsh, EE. Epidemiology and management of uterine fibroids. Int J Gynecol Obstet 2020;149:3\u20139. https:\/\/doi.org\/10.1002\/ijgo.13102.","DOI":"10.1002\/ijgo.13102"},{"key":"2026101405560755099_j_jib-2024-0045_ref_003","doi-asserted-by":"crossref","unstructured":"Lou, Z, Huang, Y, Li, S, Luo, Z, Li, C, Chu, K, et al.. Global, regional, and national time trends in incidence, prevalence, years lived with disability for uterine fibroids, 1990\u20132019: an age-period-cohort analysis for the global burden of disease 2019 study. BMC Public Health 2023;23:916. https:\/\/doi.org\/10.1186\/s12889-023-15765-x.","DOI":"10.1186\/s12889-023-15765-x"},{"key":"2026101405560755099_j_jib-2024-0045_ref_004","doi-asserted-by":"crossref","unstructured":"Stewart, EA, Cookson, CL, Gandolfo, RA, Schulze-Rath, R. Epidemiology of uterine fibroids: a systematic review. BJOG 2017;124:1501\u201312. https:\/\/doi.org\/10.1111\/1471-0528.14640.","DOI":"10.1111\/1471-0528.14640"},{"key":"2026101405560755099_j_jib-2024-0045_ref_005","doi-asserted-by":"crossref","unstructured":"Ahmad, A, Kumar, M, Bhoi, NR, Badruddeen, Akhtar, J, Khan, MI, et al.. Diagnosis and management of uterine fibroids: current trends and future strategies. J Basic Clin Physiol Pharmacol 2023;34:291\u2013310. https:\/\/doi.org\/10.1515\/jbcpp-2022-0219.","DOI":"10.1515\/jbcpp-2022-0219"},{"key":"2026101405560755099_j_jib-2024-0045_ref_006","doi-asserted-by":"crossref","unstructured":"Lim, WH, Cohen, SC, Lamaro, VP. Intra-abdominal haemorrhage from uterine fibroids: a systematic review of the literature. BMC Surg 2020;20:70. https:\/\/doi.org\/10.1186\/s12893-020-00736-5.","DOI":"10.1186\/s12893-020-00736-5"},{"key":"2026101405560755099_j_jib-2024-0045_ref_007","doi-asserted-by":"crossref","unstructured":"Pavone, D, Clemenza, S, Sorbi, F, Fambrini, M, Petraglia, F. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol 2018;46:3\u201311. https:\/\/doi.org\/10.1016\/j.bpobgyn.2017.09.004.","DOI":"10.1016\/j.bpobgyn.2017.09.004"},{"key":"2026101405560755099_j_jib-2024-0045_ref_008","doi-asserted-by":"crossref","unstructured":"Golovchenko, I. Genetic determinants of sex hormone levels in endometriosis patients. Res Results Biomed 2023;9:5\u201321.","DOI":"10.18413\/2658-6533-2023-9-1-0-1"},{"key":"2026101405560755099_j_jib-2024-0045_ref_009","doi-asserted-by":"crossref","unstructured":"Commandeur, AE, Styer, AK, Teixeira, JM. 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Genetic association studies in uterine fibroids: risk alleles presage the path to personalized therapies. Semin Reprod Med 2016;34:235\u201341. https:\/\/doi.org\/10.1055\/s-0036-1585401.","DOI":"10.1055\/s-0036-1585401"},{"key":"2026101405560755099_j_jib-2024-0045_ref_024","doi-asserted-by":"crossref","unstructured":"Hellwege, JN, Jeff, JM, Wise, LA, Gallagher, CS, Wellons, M, Hartmann, KE, et al.. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet 2017;136:1363\u201373. https:\/\/doi.org\/10.1007\/s00439-017-1836-1.","DOI":"10.1007\/s00439-017-1836-1"},{"key":"2026101405560755099_j_jib-2024-0045_ref_025","doi-asserted-by":"crossref","unstructured":"Gallagher, CS, M\u00e4kinen, N, Harris, HR, Rahmioglu, N, Uimari, O, Cook, JP, et al.. Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. 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