{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:54:34Z","timestamp":1776660874089,"version":"3.51.2"},"reference-count":13,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jom-2020-0005_abs_001_w2aab3b7c25b1b6b1aab1c16b1Aa\">\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Term neonates treated with therapeutic hypothermia (TH) may experience delays in acquiring skills for oral feeding, thus prolonging hospital admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jom-2020-0005_abs_002_w2aab3b7c25b1b6b1aab1c16b2Aa\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether osteopathic manipulative treatment (OMT) can decrease the overall length of stay (LOS) for term neonates by accelerating the transition to full oral feeds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jom-2020-0005_abs_003_w2aab3b7c25b1b6b1aab1c16b3Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A pilot study was conducted to compare LOS in term neonates treated with OMT to matched historical controls. Eligibility criteria were gestational age greater than or equal to 37\u00a0weeks, mild to moderate encephalopathy, absent seizure activity, and no brain injury on magnetic resonance imaging. Treated neonates had OMT twice between day of life four and seven, then twice per week on nonconsecutive days until hospital discharge. Secondary outcomes were to compare the number of days with nasogastric tube in both OMT and historically matched control groups and to characterize somatic dysfunction patterns in the primary affected areas of the craniosacral mechanism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jom-2020-0005_abs_004_w2aab3b7c25b1b6b1aab1c16b4Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve of 28 neonates treated with TH between October 2017 and August 2018 met eligibility criteria for the study and were matched 3:1 to 36 historical controls. On average, mothers of neonates who received OMT were older than the historical control mothers (31.3\u00a0years [SD, \u00b16.0] vs. 27.4 [SD, \u00b14.5]; p=0.02) Nineteen of the 36 historical control neonates, but no neonates in the OMT group, were intubated for a median of two days (interquartile range 1, 4). The mean LOS in the OMT group was 9.1 vs. 11.6\u00a0days for historical controls (p=0.048); however, in a sensitivity analysis excluding intubated neonates from the historical controls, the difference was 9.1 vs. 10.1\u00a0days (p=0.21). All neonates were orally feeding at discharge. Neonates given OMT had between two and four treatments lasting 8\u201320\u00a0minutes. By the final treatment, the craniosacral mechanism\u2019s intraosseous and cranial base compressions and physiologic motion were improved. There were no adverse effects noted during OMT sessions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jom-2020-0005_abs_005_w2aab3b7c25b1b6b1aab1c16b5Aa\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that OMT performed on term neonates treated with TH may decrease the amount of time needed to acquire the necessary skills for oral feeding. Although this result was not statistically significant, it may be clinically significant. A larger prospective clinical trial may have the power needed to detect a statistically significant reduction in LOS and number of days to full oral feeds in this patient population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/jom-2020-0005","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T02:28:48Z","timestamp":1613874528000},"page":"97-104","source":"Crossref","is-referenced-by-count":4,"title":["Pilot study assessing the effect of osteopathic manipulative treatment (OMT) on length of stay in neonates after therapeutic hypothermia"],"prefix":"10.1515","volume":"121","author":[{"given":"Kira","family":"Bendixen","sequence":"first","affiliation":[{"name":"Bristol Bay Area Health Corporation , Dillingham , AK , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Beinlich","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pediatrics, Maine Medical Center , Portland , ME , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Beck","sequence":"additional","affiliation":[{"name":"Hospital Manipulation Service, Maine Medical Center , Portland , ME , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabeel","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine , Boston , MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa","family":"Craig","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine , Boston , MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2021022021042837108_j_jom-2020-0005_ref_001_w2aab3b7c25b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Pfister, RH, Soll, RF. Hypothermia for the treatment of infants with hypoxic-ischemic encephalopathy. J Perinatol. 2010;30 Suppl:S82-87. https:\/\/doi.org\/10.1038\/jp.2010.91","DOI":"10.1038\/jp.2010.91"},{"key":"2021022021042837108_j_jom-2020-0005_ref_002_w2aab3b7c25b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Shankaran, S, Laptook, AR, Ehrenkranz, RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353(15):1574-1584. https:\/\/doi.org\/10.1056\/nejmcps050929","DOI":"10.1056\/NEJMcps050929"},{"key":"2021022021042837108_j_jom-2020-0005_ref_003_w2aab3b7c25b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Azzopardi, D, Brocklehurst, P, Edwards, D, et al. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. 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