{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:58:07Z","timestamp":1756810687876},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hemoglobin A1c (HbA1c) is a very common measure utilized to diagnose diabetes and to monitor the level of glycemic control during the course of management. Despite the high utility of HbA1c, it has some limitations. Physiological conditions that affect the lifespan of red blood cells (RBCs) can falsely elevate or lower HbA1c results. In this case report, we present a case of a patient who was found to have hereditary spherocytosis (HS) after developing nephrotic range proteinuria. The patient had diabetes that was previously thought to be well controlled, but his HS was masking his poor glycemic control. This case highlights the importance of understanding the limitations of the HbA1c in managing patients with diabetes.<\/jats:p>","DOI":"10.1515\/jom-2020-0055","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T09:48:50Z","timestamp":1637401730000},"page":"65-68","source":"Crossref","is-referenced-by-count":1,"title":["Bursting the bubble: hereditary spherocytosis masking poor glycemic control"],"prefix":"10.1515","volume":"122","author":[{"given":"Ashley","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , UConn Health Center , Farmington , CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deep","family":"Pachu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , UConn Health Center , Farmington , CT , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Hadfield","sequence":"additional","affiliation":[{"name":"Brown University\/Alpert School of Medicine, Department of Hematology\/Oncology , Providence , RI , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"2023040101180490956_j_jom-2020-0055_ref_001","doi-asserted-by":"crossref","unstructured":"Campbell, RC, Ruggenenti, P, Remuzzi, G. Proteinuria in diabetic nephropathy: treatment and evolution. Curr Diabetes Rep 2003;3:497\u2013504. https:\/\/doi.org\/10.1007\/s11892-003-0014-0.","DOI":"10.1007\/s11892-003-0014-0"},{"key":"2023040101180490956_j_jom-2020-0055_ref_002","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Classification and diagnosis of diabetes: standards of medical care in diabetes\u00a0\u2013 2020. Diabetes Care 2020;43:S14\u201331. https:\/\/doi.org\/10.2337\/dc20-S002.","DOI":"10.2337\/dc20-S002"},{"key":"2023040101180490956_j_jom-2020-0055_ref_003","doi-asserted-by":"crossref","unstructured":"Shepard, JG, Airee, A, Dake, AW, McFarland, MS, Vora, A. Limitations of A1c interpretation. South Med J 2015;108:724\u20139. https:\/\/doi.org\/10.14423\/SMJ.0000000000000381.","DOI":"10.14423\/SMJ.0000000000000381"},{"key":"2023040101180490956_j_jom-2020-0055_ref_004","doi-asserted-by":"crossref","unstructured":"Saudek, CD, Derr, RL, Kalyani, RR. Assessing glycemia in diabetes using blood glucose and hemoglobin A1c. J Am Med Assoc 2006;295:1688\u201397. https:\/\/doi.org\/10.1001\/jama.295.14.1688.","DOI":"10.1001\/jama.295.14.1688"},{"key":"2023040101180490956_j_jom-2020-0055_ref_005","doi-asserted-by":"crossref","unstructured":"Lorenzo-Medina, M, De-La-Iglesia, S, Ropero, P, Nogueira-Salgueiro, P, Santana-Benitez, J. Effects of hemoglobin variants on hemoglobin A1c values measured using a high-performance liquid chromatography method. J Diabetes Sci Technol 2014;8:1168\u201376. https:\/\/doi.org\/10.1177\/1932296814538774.","DOI":"10.1177\/1932296814538774"},{"key":"2023040101180490956_j_jom-2020-0055_ref_006","doi-asserted-by":"crossref","unstructured":"Radin, MS. Pitfalls in hemoglobin A1c measurement: when results may be misleading. J Gen Intern Med 2014;29:388\u201394. https:\/\/doi.org\/10.1007\/s11606-013-2595-x.","DOI":"10.1007\/s11606-013-2595-x"},{"key":"2023040101180490956_j_jom-2020-0055_ref_007","unstructured":"HbA1c assay interferences. NGSP\u00a0\u2013 harmonizing hemoglobin A1c testing; 2020. Available from: http:\/\/www.ngsp.org\/interf.asp."},{"key":"2023040101180490956_j_jom-2020-0055_ref_008","doi-asserted-by":"crossref","unstructured":"Lacy, ME, Wellenius, GA, Sumner, AE, Correa, A, Carnethon, MR, Liem, RI, et al.. Association of sickle cell trait with hemoglobin A1c in African Americans. J Am Med Assoc 2017;317:507\u201315. https:\/\/doi.org\/10.1001\/jama.2016.21035.","DOI":"10.1001\/jama.2016.21035"},{"key":"2023040101180490956_j_jom-2020-0055_ref_009","doi-asserted-by":"crossref","unstructured":"Danese, E, Montagnana, M, Nouvenne, A, Lippi, G. Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetes. J Diabetes Sci Technol 2015;9:169\u201376. https:\/\/doi.org\/10.1177\/1932296814567227.","DOI":"10.1177\/1932296814567227"},{"key":"2023040101180490956_j_jom-2020-0055_ref_010","doi-asserted-by":"crossref","unstructured":"Ribeiro, RT, Macedo, MP, Raposo, JF. HbA1c, fructosamine, and glycated albumin in the detection of dysglycaemic conditions. Curr Diabetes Rev 2016;12:14\u20139. https:\/\/doi.org\/10.2174\/1573399811666150701143112.","DOI":"10.2174\/1573399811666150701143112"}],"container-title":["Journal of Osteopathic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2020-0055\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2020-0055\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T19:15:19Z","timestamp":1680376519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2020-0055\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,11,22]]},"published-print":{"date-parts":[[2021,12,21]]}},"alternative-id":["10.1515\/jom-2020-0055"],"URL":"https:\/\/doi.org\/10.1515\/jom-2020-0055","relation":{},"ISSN":["2702-3648"],"issn-type":[{"value":"2702-3648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]}}}