{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T20:10:56Z","timestamp":1680379856420},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pfizer-BioNTech BNT162b2 is one of the three U.S. Food and Drug Administration (FDA)-approved vaccines for the prevention of COVID-19. Its most common side\u00a0effect, injection site pain, occurs because of locally recruited inflammatory mediators and is mitigated by the lymphatic system. Side effects may discourage individuals from receiving vaccines; therefore, reducing the duration of injection site pain can promote vaccination compliance. Osteopathic manipulative treatments (OMT) can directly affect the physiology underlying muscle soreness; however, there is currently no literature that supports the use of OMT in this scenario. In this case report, an otherwise healthy male presented with acute left deltoid soreness after receiving the Pfizer COVID-19 vaccine. The pain began 5\u00a0h prior to the visit. Three hours after being treated with lymphatic OMT, the severity of the pain was significantly reduced and was alleviated 8h after onset in comparison to the median duration of 24\u201348\u00a0h. He received his second dose 3\u00a0weeks later. This case report can provide future studies with the groundwork for further investigating the role of OMT in treating postvaccination muscle soreness, which can improve patient satisfaction and potentially promote vaccination compliance.<\/jats:p>","DOI":"10.1515\/jom-2021-0189","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T13:05:28Z","timestamp":1641906328000},"page":"153-157","source":"Crossref","is-referenced-by-count":3,"title":["Lymphatic osteopathic manipulative treatment reduces duration of deltoid soreness after Pfizer\/BioNTech COVID-19 vaccine"],"prefix":"10.1515","volume":"122","author":[{"given":"Sylvia","family":"Marshall","sequence":"first","affiliation":[{"name":"Academic Medicine Scholars Program, New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of PA Studies , New York Institute of Technology School of Health Professions , Old Westbury , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Capobianco","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Manipulative Medicine , New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"2023040101210975851_j_jom-2021-0189_ref_001","unstructured":"COVID Data Tracker: COVID-19 vaccinations in the United States. Center for Disease Control and Prevention; 2021. https:\/\/covid.cdc.gov\/covid-data-tracker\/#vaccinations [Accessed 16 June 2021]."},{"key":"2023040101210975851_j_jom-2021-0189_ref_002","unstructured":"Local reactions, systemic reactions, adverse events, and serious adverse events: Pfizer-BioNTech COVID-19 vaccine. Center for Disease Control and Prevention; 2021. https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/pfizer\/reactogenicity.html [Accessed 29 May 2021]."},{"key":"2023040101210975851_j_jom-2021-0189_ref_003","doi-asserted-by":"crossref","unstructured":"Opstelten, W, Hak, E, Verheij, TJ, van Essen, GA. Introducing a pneumococcal vaccine to an existing influenza immunization program: vaccination rates and predictors of noncompliance. Am J Med 2001;111:474\u20139. https:\/\/doi.org\/10.1016\/s0002-9343(01)00880-4.","DOI":"10.1016\/S0002-9343(01)00880-4"},{"key":"2023040101210975851_j_jom-2021-0189_ref_004","doi-asserted-by":"crossref","unstructured":"Wicker, S, Rabenau, HF, Doerr, HW, Allwinn, R. Influenza vaccination compliance among health care workers in a German University Hospital. Infection 2009;37:197\u2013202. https:\/\/doi.org\/10.1007\/s15010-008-8200-2.","DOI":"10.1007\/s15010-008-8200-2"},{"key":"2023040101210975851_j_jom-2021-0189_ref_005","unstructured":"Local reactions, systemic reactions, adverse events, and serious adverse events: moderna COVID-19 vaccine. Center for Disease Control and Prevention; 2021. https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/moderna\/reactogenicity.html [Accessed 20 June 2021]."},{"key":"2023040101210975851_j_jom-2021-0189_ref_006","doi-asserted-by":"crossref","unstructured":"Pal, I, Ramsey, JD. The role of the lymphatic system in vaccine trafficking and immune response. Adv Drug Deliv Rev 2011;63:909\u201322. https:\/\/doi.org\/10.1016\/j.addr.2011.05.018.","DOI":"10.1016\/j.addr.2011.05.018"},{"key":"2023040101210975851_j_jom-2021-0189_ref_007","doi-asserted-by":"crossref","unstructured":"Mills, MV, Henley, CE, Barnes, LL, Carreiro, JE, Degenhardt, BF. The use of osteopathic manipulative treatment as adjuvant therapy in children with recurrent acute otitis media. Arch Pediatr Adolesc Med 2003;157:861\u20136. https:\/\/doi.org\/10.1001\/archpedi.157.9.861.","DOI":"10.1001\/archpedi.157.9.861"},{"key":"2023040101210975851_j_jom-2021-0189_ref_008","doi-asserted-by":"crossref","unstructured":"Kilgore, T, Malia, M, Di Giacinto, B, Minter, S, Samies, J. Adjuvant lymphatic osteopathic manipulative treatment in patients with lower-extremity ulcers: effects on wound healing and edema. J Am Osteopath Assoc 2018;118:798\u2013805. https:\/\/doi.org\/10.7556\/jaoa.2018.172.","DOI":"10.7556\/jaoa.2018.172"},{"key":"2023040101210975851_j_jom-2021-0189_ref_009","doi-asserted-by":"crossref","unstructured":"Yao, S, Hassani, J, Gagne, M, George, G, Gilliar, W. Osteopathic manipulative treatment as a useful adjunctive tool for pneumonia. J Vis Exp 2014;87:50687. https:\/\/doi.org\/10.3791\/50687.","DOI":"10.3791\/50687-v"},{"key":"2023040101210975851_j_jom-2021-0189_ref_010","unstructured":"Jackson, KM, Steele, TF, Dugan, EP, Kukulka, G, Blue, W, Roberts, A. Effect of lymphatic and splenic pump techniques on the antibody response to hepatitis B vaccine: a pilot study. J Am Osteopath Assoc 1998;98:155\u201360."},{"key":"2023040101210975851_j_jom-2021-0189_ref_011","doi-asserted-by":"crossref","unstructured":"Veera, S, Chin, J, Kleyn, L, Spinelli, S, Tafler, L. Use of osteopathic manipulation for treatment of chronic shoulder injury related to vaccine administration. Cureus 2020;12:e9156. https:\/\/doi.org\/10.7759\/cureus.9156.","DOI":"10.7759\/cureus.9156"},{"key":"2023040101210975851_j_jom-2021-0189_ref_012","unstructured":"Seffinger, MA. Chapter 40A: Acutely ill or hospitalized patients: osteopathic considerations and approaches using OMT. In: Seffinger, MA, ed. Foundations of osteopathic medicine: philosophy, science, clinical applications, and research, 4th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2018."},{"key":"2023040101210975851_j_jom-2021-0189_ref_013","unstructured":"Nicholas, A, Nicholas, E. Chapter 16: Lymphatic techniques. In: Atlas of osteopathic techniques, 3rd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2015."},{"key":"2023040101210975851_j_jom-2021-0189_ref_014","unstructured":"Essig-Beatty, DR, Li, T, Steele, KM, Comeaux, ZJ, Garlitz, JM. Chapter 11: Upper extremity diagnosis and treatment. In: The pocket manual of OMT: osteopathic manipulative medicine, 2nd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2010."},{"key":"2023040101210975851_j_jom-2021-0189_ref_015","doi-asserted-by":"crossref","unstructured":"Herv\u00e9, C, Laup\u00e8ze, B, Del Giudice, G, Didierlaurent, AM, Tavares Da Silva, F. The how\u2019s and what\u2019s of vaccine reactogenicity. NPJ Vaccines 2019;4:39. https:\/\/doi.org\/10.1038\/s41541-019-0132-6.","DOI":"10.1038\/s41541-019-0132-6"},{"key":"2023040101210975851_j_jom-2021-0189_ref_016","doi-asserted-by":"crossref","unstructured":"Moore, JEJr, Bertram, CD. Lymphatic system flows. Annu Rev Fluid Mech 2018;50:459\u201382. https:\/\/doi.org\/10.1146\/annurev-fluid-122316-045259.","DOI":"10.1146\/annurev-fluid-122316-045259"},{"key":"2023040101210975851_j_jom-2021-0189_ref_017","doi-asserted-by":"crossref","unstructured":"Skandalakis, JE, Skandalakis, LJ, Skandalakis, PN. Anatomy of the lymphatics. Surg Oncol Clin N Am 2007;16:1\u201316. https:\/\/doi.org\/10.1016\/j.soc.2006.10.006.","DOI":"10.1016\/j.soc.2006.10.006"},{"key":"2023040101210975851_j_jom-2021-0189_ref_018","doi-asserted-by":"crossref","unstructured":"Schander, A, Downey, HF, Hodge, LM. Lymphatic pump manipulation mobilizes inflammatory mediators into lymphatic circulation. Exp Biol Med (Maywood) 2012;237:58\u201363. https:\/\/doi.org\/10.1258\/ebm.2011.011220.","DOI":"10.1258\/ebm.2011.011220"},{"key":"2023040101210975851_j_jom-2021-0189_ref_019","doi-asserted-by":"crossref","unstructured":"Koul, R, Dufan, T, Russell, C, Guenther, W, Nugent, Z, Sun, X, et al.. Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer. Int J Radiat Oncol Biol Phys 2007;67:841\u20136. https:\/\/doi.org\/10.1016\/j.ijrobp.2006.09.024.","DOI":"10.1016\/j.ijrobp.2006.09.024"},{"key":"2023040101210975851_j_jom-2021-0189_ref_020","unstructured":"DeStefano, LA. Chapter 7: Principles of soft-tissue and other peripheral stimulating techniques. In: Hauber, M, Nicholl, G, eds. Greenman\u2019s principles of manual medicine, 5th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2017."}],"container-title":["Journal of Osteopathic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2021-0189\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2021-0189\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T19:55:17Z","timestamp":1680378917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jom-2021-0189\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2,23]]},"published-print":{"date-parts":[[2022,2,23]]}},"alternative-id":["10.1515\/jom-2021-0189"],"URL":"https:\/\/doi.org\/10.1515\/jom-2021-0189","relation":{},"ISSN":["2702-3648"],"issn-type":[{"value":"2702-3648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]}}}