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It is thought to be due to muscle hypertrophy and is\u00a0classically associated with young athletes under 30, overtraining, anabolic steroid use, and aberrant running biomechanics. We present a unique case of CECS in a patient without the traditional risk factors but rather diagnosed with cardiac cirrhosis and portal hypertension. This patient\u2019s exercise-induced bilateral leg pain met the\u00a0CECS criteria for leg compartment pressure testing and\u00a0was attributed to fluid retention secondary to his comorbidities. His symptoms significantly improved after\u00a0initiating diuretic pharmacotherapy. Based on our\u00a0literature review, there is a dearth of literature associating CECS with specific chronic cardiac or hepatic\u00a0conditions as well as describing its incidence in\u00a0these conditions.<\/jats:p>","DOI":"10.1515\/jom-2022-0061","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T14:17:40Z","timestamp":1663165060000},"page":"631-634","source":"Crossref","is-referenced-by-count":0,"title":["Chronic exertional compartment syndrome in a patient with restrictive cardiomyopathy and portal hypertension"],"prefix":"10.1515","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-2590","authenticated-orcid":false,"given":"Christopher","family":"Lu","sequence":"first","affiliation":[{"name":"Montefiore Medical Center , Department of Physical Medicine & Rehabilitation , Bronx , NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Yoo","sequence":"additional","affiliation":[{"name":"Spine Care and Department of Physical Medicine & Rehabilitation , Mayo Clinic Arizona , Phoenix , AZ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J.","family":"De Luigi","sequence":"additional","affiliation":[{"name":"Spine Care, Sports Medicine, and Department of Physical Medicine & Rehabilitation , Mayo Clinic Arizona , Phoenix , AZ , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"2022111808534452302_j_jom-2022-0061_ref_001","doi-asserted-by":"crossref","unstructured":"Buerba, RA, Fretes, NF, Devana, SK, Beck, JJ. 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