{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:58Z","timestamp":1788447778895,"version":"build-2803163510"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jom-2025-0036_abs_001\">\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Patients with Ehlers-Danlos Syndrome (EDS) and hypermobility spectrum disorder (HSD) often complain of palpitations, presyncope\/syncope, attributable to postural orthostatic tachycardia syndrome (POTS). Occasionally, the etiology of these complaints is not positional, unclear, and may require further cardiac evaluation, including cardiac monitoring. To our knowledge, the utility of implantable loop recorders (ILRs) has yet to be explored in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0036_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the utility of the ILRs in diagnosing and\/or excluding arrhythmias not attributable to POTS in symptomatic patients with EDS and\u00a0HSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0036_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with EDS and HSD were referred from the New York Institute of Technology (NYIT) Ehlers-Danlos Syndrome\/Hypermobility Treatment Center to the Long Island Heart Rhythm Center (LIHRC) for cardiac evaluation between January 2019 and November 2023. A retrospective analysis of observational de-identified data from the LIHRC was permitted by the NYIT College of Osteopathic Medicine Institutional Review Board (BHS-1465). Patients were monitored monthly, and the utility of the ILRs was assessed based on a correlation of symptoms to an arrhythmia, the ability of the device to monitor therapy efficacy, and\/or to rule out an arrhythmia as the explanation of symptoms. Data is reported as percentages and mean\u00a0\u00b1\u00a0standard deviation\u00a0(SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0036_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 116 hypermobile patients (81 EDS\/35 HSD) were evaluated. Among these patients, 31 (26.7\u202f%) received an ILR (length of follow-up, 27.3\u00a0months\u00a0\u00b1\u00a014.0\u00a0months), 29 females\/2 males, 28 patients had EDS, 3 patients had HSD, age 34.1\u00a0\u00b1\u00a011.4 years. Symptomatic sinus tachycardia (ST) occurred in 16 patients (51.6\u202f%), and ST helped diagnose POTS and\/or monitor therapy in 15 (48.4\u202f%). Symptomatic premature ventricular complexes (PVCs) occurred in 8 patients (25.8\u202f%), supraventricular tachycardia (SVT) in 6 (19.4\u202f%), and ventricular tachycardia (VT) in 1 (3.2\u202f%). In 2 patients, ILR findings led to further interventions, including PVC ablation and an implantable cardioverter-defibrillator (ICD) for symptomatic VT. The ILR demonstrated utility in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0036_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated the utility of the ILR in identifying symptomatic arrhythmias in patients with EDS and HSD. ILR monitoring also aided in solidifying a POTS diagnosis and guiding patient management\/treatment efficacy. Further evaluation in a larger cohort is needed to further understand the impact of ILR monitoring in hypermobile patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jom-2025-0036","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T09:45:59Z","timestamp":1750239959000},"page":"123-128","source":"Crossref","is-referenced-by-count":1,"title":["The utility of the implantable loop recorder in patients with Ehlers-Danlos syndrome and hypermobility spectrum disorder"],"prefix":"10.1515","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9245-6168","authenticated-orcid":false,"given":"Ermin","family":"Tale","sequence":"first","affiliation":[{"name":"43984 New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"},{"name":"Jacobi Medical Center\/Albert Einstein College of Medicine , Department of Medicine , Bronx , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Robinson","sequence":"additional","affiliation":[{"name":"43984 New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Edward","sequence":"additional","affiliation":[{"name":"43984 New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8673-9871","authenticated-orcid":false,"given":"Riya","family":"Kaushal","sequence":"additional","affiliation":[{"name":"43984 New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Riley","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialties , New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"43984 New York Institute of Technology College of Osteopathic Medicine , Old Westbury , NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"2026022111564635582_j_jom-2025-0036_ref_001","unstructured":"National Organization for Rare Disorders. Ehlers Danlos syndrome\u00a0\u2013\u00a0symptoms, causes, treatment: Nord; 2024. https:\/\/rarediseases.org\/rare-diseases\/ehlers-danlos-syndrome\/ [Accessed 15 March 2025]."},{"key":"2026022111564635582_j_jom-2025-0036_ref_002","doi-asserted-by":"crossref","unstructured":"Malfait, F, Francomano, C, Byers, PH, Belmont, J, Berglund, B, Black, J, et al.. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 2017;175:8\u201326. https:\/\/doi.org\/10.1002\/ajmg.c.31552.","DOI":"10.1002\/ajmg.c.31552"},{"key":"2026022111564635582_j_jom-2025-0036_ref_003","doi-asserted-by":"crossref","unstructured":"Riley, B. The many facets of hypermobile Ehlers-Danlos syndrome. J\u00a0Osteopath Med 2020;120:30\u20132. https:\/\/doi.org\/10.7556\/jaoa.2020.012.","DOI":"10.7556\/jaoa.2020.012"},{"key":"2026022111564635582_j_jom-2025-0036_ref_004","doi-asserted-by":"crossref","unstructured":"Bryarly, M, Phillips, L, Fu, Q, Vernino, S, Levine, BD. Postural orthostatic tachycardia syndrome: JACC Focus Seminar. J\u00a0Am Coll Cardiol 2019;73:1207\u201328. https:\/\/doi.org\/10.1016\/j.jacc.2018.11.059.","DOI":"10.1016\/j.jacc.2018.11.059"},{"key":"2026022111564635582_j_jom-2025-0036_ref_005","doi-asserted-by":"crossref","unstructured":"Marcus, F, McKenna, W, Sherrill, D, Basso, C, Bauce, B, Bluemke, DA, et al.. Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria. Circulation 2010;121. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.108.840827.","DOI":"10.1161\/CIRCULATIONAHA.108.840827"},{"key":"2026022111564635582_j_jom-2025-0036_ref_006","doi-asserted-by":"crossref","unstructured":"S\u0142awi\u0144ski, G, Wabich, E, Hawryszko, M, Dani\u0142owicz-Szymanowicz, L, Chevalier, P. Therapeutic difficulties in a patient with Ehlers-Danlos syndrome and numerous symptomatic premature ventricular contractions\u2014case report and literature review. 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J\u00a0Cardiovasc Electrophysiol 2024;35:2134\u201343. https:\/\/doi.org\/10.1111\/jce.16420.","DOI":"10.1111\/jce.16420"},{"key":"2026022111564635582_j_jom-2025-0036_ref_013","doi-asserted-by":"crossref","unstructured":"Buck, BH, Hill, MD, Quinn, FR, Butcher, KS, Menon, BK, Gulamhusein, S, et al.. Effect of implantable vs prolonged external electrocardiographic monitoring on atrial fibrillation detection in patients with ischemic stroke: the PER DIEM randomized clinical trial. JAMA 2021;325:2160\u20138. https:\/\/doi.org\/10.1001\/jama.2021.6128.","DOI":"10.1001\/jama.2021.6128"},{"key":"2026022111564635582_j_jom-2025-0036_ref_014","doi-asserted-by":"crossref","unstructured":"Pietri-Toro, JM, Gardner, OK, Leuchter, JD, DiBartolomeo, G, Hunter, JA, Forghani, I. Prevalence of cardiovascular manifestations in patients with hypermobile Ehlers-Danlos syndrome at the University of Miami. 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