{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:05:43Z","timestamp":1789974343222,"version":"4.0.1"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"10","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Acute lateral ankle sprain (ALAS) is responsible for short-term disability, increased risk for future acute ankle sprain, and chronic ankle instability. Several studies highlighted that manipulative therapy may reduce pain and increase the range of motion (ROM) of the injured ankle, but not all of them targeted acute injuries. Some studies focused their interest on a specific manipulative technique or utilized either physiotherapy or chiropractic techniques.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The objectives of this study were to evaluate the effectiveness of osteopathic care in ALAS, to assess pain, edema, and functional stability of the injured ankle, and to assess and comparing mobility between the injured and noninjured\u00a0ankle.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted an interventional randomized controlled trial (RCT) in the emergency department (ED) of a French University Hospital. Fifty patients were enrolled in this study. They had to be\u00a0\u226518\u00a0years old, consulting in the ED for a single ALAS (<72\u202fh) stage 1 or 2, and must have had preliminary consultation with an emergency physician. Patients with an ALAS stage 3 or fractured, or with history of homolateral ankle surgery, were excluded. Patients were randomized either in the medical treatment (MT) group or in the medical and osteopathic treatment (MOT) group and had a 3-week follow-up. In the MOT group, the intervention consisted of a single osteopathic treatment (manual intervention) at Day 0, depending on the tissue affected and on the intensity of the tissular tension found, and individualized advice provided at Days 0, 7, and 21. Comparisons between groups were investigated utilizing the chi-square or Fisher\u2019s exact test, or Student\u2019s\n t<\/jats:italic>\n -test or Mann Whitney U-test, as appropriate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Forty-five patients completed the study. The patients\u2019 median age was 29.5\u00a0years old (23\u201340 years). At Day 21, 95.7\u202f% of patients in the MOT group had equivalent capacity of unloaded dorsal flexion between the injured and noninjured ankle, vs. 50.0\u202f% of patients in the MT group (p=0.0005). Between Day 0 and Day 21, the pain with the injured ankle loaded and unloaded decreased more significantly in the MOT group (p=0.001 and p=0.0007, respectively), while the loaded and unloaded dorsal flexion, and the unloaded plantar flexion, increased (p=0.003, p<0.0001 and p=0.02, respectively). Between Day 0 and Day 0 postosteopathic treatment, all judgment criteria showed improvement in the MOT group. At Day 7, all the functional stability tests were performed better by patients in the MOT\u00a0group.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Early osteopathic treatment associated with usual MT, delivered to patients with an ALAS, may improve mobility and functional stability, and may reduce pain and edema, in the 3\u00a0weeks postintervention. These promising findings require confirmation in a larger controlled\u00a0trial.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/jom-2025-0096","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:15:17Z","timestamp":1769080517000},"page":"481-490","source":"Crossref","is-referenced-by-count":0,"title":["Early osteopathic treatment delivered to patients with an acute lateral ankle sprain improves recovery: an investigative study"],"prefix":"10.1515","volume":"126","author":[{"given":"Claire","family":"Bournon","sequence":"first","affiliation":[{"name":"Institut Sup\u00e9rieur d\u2019Ost\u00e9opathie de Paris (ISOP) , Lognes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Prin-Conti","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur d\u2019Ost\u00e9opathie de Paris (ISOP) , Lognes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Douay","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, CHU Reims , Reims , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Alexandre","family":"Montfajon","sequence":"additional","affiliation":[{"name":"Institut Sup\u00e9rieur d\u2019Ost\u00e9opathie de Paris (ISOP) , Lognes , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukshe","family":"Kanagaratnam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, VieFra, CHU Reims, Unit\u00e9 d\u2019aide M\u00e9thodologique , Reims , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Gennai","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, CHU Reims , Reims , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"2026092106580043707_j_jom-2025-0096_ref_001","doi-asserted-by":"crossref","unstructured":"Gribble, PA, Bleakley, CM, Caulfield, BM, Docherty, CL, Fourchet, F, Fong, DTP, et al.. Evidence review for the 2016 international ankle consortium consensus statement on the prevalence, impact and long-term consequences of lateral ankle sprains. Br J Sports Med 2016;50:1496\u2013505. https:\/\/doi.org\/10.1136\/bjsports-2016-096189.","DOI":"10.1136\/bjsports-2016-096189"},{"key":"2026092106580043707_j_jom-2025-0096_ref_002","doi-asserted-by":"crossref","unstructured":"Herzog, MM, Kerr, ZY, Marshall, SW, Wikstrom, EA. Epidemiology of ankle sprains and chronic ankle instability. J\u00a0Athl Train 2019;54:603\u201310. https:\/\/doi.org\/10.4085\/1062-6050-447-17.","DOI":"10.4085\/1062-6050-447-17"},{"key":"2026092106580043707_j_jom-2025-0096_ref_003","doi-asserted-by":"crossref","unstructured":"Roos, KG, Kerr, ZY, Mauntel, TC, Djoko, A, Dompier, TP, Wikstrom, EA, et al.. The epidemiology of lateral ligament complex ankle sprains in national collegiate athletic association sports. 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The value of osteopathic recognition. Ann Fam Med 2021;19:86\u20137. https:\/\/doi.org\/10.1370\/afm.2663.","DOI":"10.1370\/afm.2663"},{"key":"2026092106580043707_j_jom-2025-0096_ref_009","unstructured":"Eisenhart, AW, Gaeta, TJ, Yens, DP. Osteopathic manipulative treatment in the emergency department for patients with acute ankle injuries. J\u00a0Am Osteopath Assoc 2003;103:417\u201321."},{"key":"2026092106580043707_j_jom-2025-0096_ref_010","doi-asserted-by":"crossref","unstructured":"Trager, RJ, Baumann, AN, Rogers, H, Tidd, J, Orellana, K, Preston, G, et al.. Efficacy of manual therapy for sacroiliac joint pain syndrome: a systematic review and meta-analysis of randomized controlled trials. J\u00a0Man Manip Ther 2024;14:1\u201312. https:\/\/doi.org\/10.1080\/10669817.2024.2316420.","DOI":"10.1080\/10669817.2024.2316420"},{"key":"2026092106580043707_j_jom-2025-0096_ref_011","unstructured":"Cuccia, AM, Caradonna, C, Caradonna, D. Manual therapy of the mandibular accessory ligaments for the management of temporomandibular joint disorders. J\u00a0Am Osteopath Assoc 2011;111:102\u201312."},{"key":"2026092106580043707_j_jom-2025-0096_ref_012","doi-asserted-by":"crossref","unstructured":"Ross, G, Macfarlane, C, Vaughan, B. Combined osteopathy and exercise management of achilles tendinopathy in an athlete. J\u00a0Sports Med Phys Fitness 2018;58:106\u201312. https:\/\/doi.org\/10.23736\/S0022-4707.17.06817-7.","DOI":"10.23736\/S0022-4707.17.06817-7"},{"key":"2026092106580043707_j_jom-2025-0096_ref_013","doi-asserted-by":"crossref","unstructured":"Zago, J, Amatuzzi, F, Rondinel, T, Matheus, JP. Osteopathic manipulative treatment versus exercise program in runners with patellofemoral pain syndrome: a randomized controlled trial. 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