{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:41:30Z","timestamp":1792680090385,"version":"4.5.0"},"reference-count":106,"publisher":"Walter de Gruyter GmbH","issue":"11","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jom-2025-0214_abs_001\">\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Depression and other mood disorders have a significant impact on patients, affecting their daily functioning, physical health, and emotional well-being. While psychopharmacological medications and psychotherapy are the most common evidence-based treatments (supported by a significant amount of scientific research), there is growing research that supports the use of complementary therapies (nonmainstream approaches utilized together with conventional medicine), including manipulative or manual therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0214_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review contributes to the existing literature by evaluating published studies on the effectiveness of various manual-therapy modalities in reducing depression symptoms, and it provides a comparative examination of these modalities as complementary treatment options for depression and related mood disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0214_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted from January to April 2025 utilizing PubMed, Embase, and Google Scholar. Search results were uploaded to DistillerSR to assist with the screening phase. The study selection process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The inclusion criteria required studies to be to be peer-reviewed, published in English, assessed mood disorder symptoms as a primary variable, utilized validated depression measures pre- and postintervention, and involved manual therapies administered by qualified professionals. Selected articles were independently evaluated by authors with two metrics: a level of evidence (LOE) table and a screening criterion incorporating specific elements from the search process. The Strength of Recommendation Taxonomy (SORT) was utilized to assess the quality of the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0214_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The literature search gathered 6,661 articles that were uploaded to DistillerSR. Then 717 duplicates were removed, so 5,944 articles were screened. Ultimately, 5,810 articles were excluded during title and abstract screening. Full-text analysis was conducted on 132 articles, of which 97 met the inclusion criteria. The following modalities were studied: acupressure, acupoint massage, bone setting, chiropractic manipulation, craniosacral therapy, energetic and light touch therapies, manual therapy, osteopathic manipulative treatment\/therapy (OMT\/OMTh), foot reflexology, massage therapy, and other soft tissue therapies. Each modality was assigned a \u201cB\u201d rating based on SORT. Seventeen studies in the review included patients with specific psychiatric diagnoses, such as major depressive disorder (MDD), depression, adjustment disorder, and seasonal affective disorder, in which manipulative therapies were evaluated for their impact on managing depressive symptoms. Out of these 17 studies, 15 (88.2\u202f%) reported that manipulative therapy led to a significant reduction in depression symptoms. The results of each modality demonstrating beneficial effects in treating depression symptoms are as follows: 6\/6 (100\u202f%) acupressure; 5\/6 (83.3\u202f%) chiropractic manipulation; 3\/3 (100\u202f%) craniosacral therapy; 8\/9 (88.9\u202f%) energetic therapies and light-touch therapies; 9\/14 (64\u202f%) manual therapy; 5\/10 (50\u202f%) OMT\/OMTh; 2\/3 (66.7\u202f%) foot reflexology; 32\/45 (71.1\u202f%) massage therapy; and 2\/5 (40\u202f%) other soft tissue therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2025-0214_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This systematic review evaluates the current literature indicating that manual therapy may be effective in reducing symptoms of depression as a complementary treatment. Research demonstrates that acupressure, craniosacral therapy, and massage therapy are consistently associated with improvements in depressive symptoms; however, further investigation into other modalities, particularly within psychiatric populations, is necessary. Ultimately, additional research is needed to substantiate the efficacy of manual therapies for individuals with psychiatric disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jom-2025-0214","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:31:43Z","timestamp":1777422703000},"page":"565-581","source":"Crossref","is-referenced-by-count":1,"title":["Manual therapy modalities and depression: a systematic review"],"prefix":"10.1515","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0589-8557","authenticated-orcid":false,"given":"Paulyna","family":"Schulz","sequence":"first","affiliation":[{"name":"Rocky Vista University College of Osteopathic Medicine , Englewood , CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodor","family":"Huzij","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Principles and Practice , Idaho College of Osteopathic Medicine , Meridian , ID , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"2026102213580748958_j_jom-2025-0214_ref_001","unstructured":"Major depression. National Institute of Mental Health; 2023. https:\/\/www.nimh.nih.gov\/health\/statistics\/major-depression [Accessed 29 Apr 2025]."},{"key":"2026102213580748958_j_jom-2025-0214_ref_002","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed. Text Revision (DSM-5-TR). Washington D.C.: American Psychiatric Publishing; 2022.","DOI":"10.1176\/appi.books.9780890425787"},{"key":"2026102213580748958_j_jom-2025-0214_ref_003","unstructured":"Trivedi, MH. The link between depression and physical symptoms. Prim Care Companion J Clin Psychiatry 2004;6(1 Suppl):12\u20136."},{"key":"2026102213580748958_j_jom-2025-0214_ref_004","doi-asserted-by":"crossref","unstructured":"Simon, G, von Korff, M, Picc\u00efnell\u00ef, M, Fullerton, C, Ormel, J. An international study of the relation between somatic symptoms and depression. N\u00a0Engl J Med 1999;341:1329\u201335. https:\/\/doi.org\/10.1056\/NEJM199910283411801.","DOI":"10.1056\/NEJM199910283411801"},{"key":"2026102213580748958_j_jom-2025-0214_ref_005","doi-asserted-by":"crossref","unstructured":"Canales, JZ, Cord\u00e1s, TA, Fiquer, JT, Cavalcante, AF, Moreno, RA. Posture and body image in individuals with major depressive disorder: a controlled study. Br J Psychiatry 2010;32:375\u201380. https:\/\/doi.org\/10.1590\/s1516-44462010000400010.","DOI":"10.1590\/S1516-44462010000400010"},{"key":"2026102213580748958_j_jom-2025-0214_ref_006","unstructured":"Seffinger, MA. Glossary of osteopathic terminology. In: Foundations of osteopathic medicine: philosophy, science, clinical applications, and research, 4th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2018."},{"key":"2026102213580748958_j_jom-2025-0214_ref_007","doi-asserted-by":"crossref","unstructured":"Page, MJ, McKenzie, JE, Bossuyt, PM, Boutron, I, Hoffmann, TC, Mulrow, CD, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. https:\/\/doi.org\/10.1136\/bmj.n71.","DOI":"10.1136\/bmj.n71"},{"key":"2026102213580748958_j_jom-2025-0214_ref_008","doi-asserted-by":"crossref","unstructured":"Ebell, MH, Siwek, J, Weiss, BD, Woolf, SH, Susman, J, Ewigman, B, et al.. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Physician 2004;69:548\u201356.","DOI":"10.3122\/jabfm.17.1.59"},{"key":"2026102213580748958_j_jom-2025-0214_ref_009","doi-asserted-by":"crossref","unstructured":"Cho, YC, Tsay, SL. The effect of acupressure with massage on fatigue and depression in patients with end-stage renal disease. J\u00a0Nurs Res 2004;12:51\u20139. https:\/\/doi.org\/10.1097\/01.jnr.0000387488.63438.9a.","DOI":"10.1097\/01.JNR.0000387488.63438.9a"},{"key":"2026102213580748958_j_jom-2025-0214_ref_010","doi-asserted-by":"crossref","unstructured":"He, C, Fei, F, Liu, P, Zhao, Y, Zhou, X, Ru, G. Application of Chinese five-tone melodies combined with acupoint massage in reducing anxiety and depression levels of elderly. TMR Integr Med 2021;5:e21016. https:\/\/doi.org\/10.53388\/TMRIM202105016.","DOI":"10.53388\/TMRIM202105016"},{"key":"2026102213580748958_j_jom-2025-0214_ref_011","doi-asserted-by":"crossref","unstructured":"Hmwe, NTT, Subramanian, P, Tan, LP, Chong, WK. The effects of acupressure on depression, anxiety and stress in patients with hemodialysis: a randomized controlled trial. Int J Nurs Stud 2015;52:509\u201318. https:\/\/doi.org\/10.1016\/j.ijnurstu.2014.11.002.","DOI":"10.1016\/j.ijnurstu.2014.11.002"},{"key":"2026102213580748958_j_jom-2025-0214_ref_012","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Mansilla, J, Gonz\u00e1lez L\u00f3pez-Arza, MV, Varela-Donoso, E, Montanero-Fern\u00e1ndez, J, Gonz\u00e1lez S\u00e1nchez, B, Garrido-Ardila, EM. The effects of ear acupressure, massage therapy and no therapy on symptoms of dementia: a randomized controlled trial. Clin Rehabil 2015;29:683\u201393. https:\/\/doi.org\/10.1177\/0269215514554240.","DOI":"10.1177\/0269215514554240"},{"key":"2026102213580748958_j_jom-2025-0214_ref_013","doi-asserted-by":"crossref","unstructured":"Sok, SR. Effects of meridian acupressure in Joktaeyang Bangkwang Kyeong on the physical health state, depression, and life satisfaction of Korean older adult women living alone. J\u00a0Gerontol Nurs 2016;42:28\u201335. https:\/\/doi.org\/10.3928\/00989134-20151218-01.","DOI":"10.3928\/00989134-20151218-01"},{"key":"2026102213580748958_j_jom-2025-0214_ref_014","doi-asserted-by":"crossref","unstructured":"Wu, HS, Lin, LC, Wu, SC, Lin, JG. The psychologic consequences of chronic dyspnea in chronic pulmonary obstruction disease: the effects of acupressure on depression. J\u00a0Alternative Compl Med 2007;13:253\u201361. https:\/\/doi.org\/10.1089\/acm.2006.5342.","DOI":"10.1089\/acm.2006.5342"},{"key":"2026102213580748958_j_jom-2025-0214_ref_015","doi-asserted-by":"crossref","unstructured":"Hemmil\u00e4, HM. Bone setting for prolonged neck pain: a randomized clinical trial. J\u00a0Manipulative Physiol Therapeut 2005;28:508\u201315. https:\/\/doi.org\/10.1016\/j.jmpt.2005.07.008.","DOI":"10.1016\/j.jmpt.2005.07.008"},{"key":"2026102213580748958_j_jom-2025-0214_ref_016","doi-asserted-by":"crossref","unstructured":"Elder, C, DeBar, L, Ritenbaugh, C, Dickerson, J, Vollmer, WM, Deyo, RA, et al.. Comparative effectiveness of usual care with or without chiropractic care in patients with recurrent musculoskeletal back and neck pain. J\u00a0Gen Intern Med 2018;33:1469\u201377. https:\/\/doi.org\/10.1007\/s11606-018-4539-y.","DOI":"10.1007\/s11606-018-4539-y"},{"key":"2026102213580748958_j_jom-2025-0214_ref_017","doi-asserted-by":"crossref","unstructured":"Gevers-Montoro, C, Romero-Santiago, B, Medina-Garc\u00eda, I, Larranaga-Arzamendi, B, \u00c1lvarez-G\u00e1lovich, L, Ortega-De Mues, A, et al.. Reduction of chronic primary low back pain by spinal manipulative therapy is accompanied by decreases in segmental mechanical hyperalgesia and pain catastrophizing: a randomized placebo-controlled dual-blind mixed experimental trial. J\u00a0Pain 2024;25:104500. https:\/\/doi.org\/10.1016\/j.jpain.2024.02.014.","DOI":"10.1016\/j.jpain.2024.02.014"},{"key":"2026102213580748958_j_jom-2025-0214_ref_018","unstructured":"Hawk, C, Long, C, Azad, A. Chiropractic care for women with chronic pelvic pain: a prospective single-group intervention study. J\u00a0Manip Physiol Ther 1997;20:73\u20139."},{"key":"2026102213580748958_j_jom-2025-0214_ref_019","doi-asserted-by":"crossref","unstructured":"Hatik, SH, Teki\u0307N, D, Bayram, KB. Comparing the effectiveness of chiropractic manipulation and muscle energy technique in sacroiliac joint dysfunction treatment. Int J Tradit Complement Med Res 2022;3:8\u201317. https:\/\/doi.org\/10.53811\/ijtcmr.1023789.","DOI":"10.53811\/ijtcmr.1023789"},{"key":"2026102213580748958_j_jom-2025-0214_ref_020","doi-asserted-by":"crossref","unstructured":"Hoiriis, KT, Pfleger, B, McDuffie, FC, Cotsonis, G, Elsangak, O, Hinson, R, et al.. A randomized clinical trial comparing chiropractic adjustments to muscle relaxants for subacute low back pain. J\u00a0Manipulative Physiol Therapeut 2004;27:388\u201398. https:\/\/doi.org\/10.1016\/j.jmpt.2004.05.003.","DOI":"10.1016\/j.jmpt.2004.05.003"},{"key":"2026102213580748958_j_jom-2025-0214_ref_021","doi-asserted-by":"crossref","unstructured":"Ghasemi, C, Amiri, A, Sarrafzadeh, J, Dadgoo, M, Maroufi, N. Comparison of the effects of craniosacral therapy, muscle energy technique, and sensorimotor training on non-specific chronic low back pain. APIC 2020;24. https:\/\/doi.org\/10.35975\/apic.v24i5.1362.","DOI":"10.35975\/apic.v24i5.1362"},{"key":"2026102213580748958_j_jom-2025-0214_ref_022","doi-asserted-by":"crossref","unstructured":"Ghasemi, C, Amiri, A, Sarrafzadeh, J, Dadgoo, M. Effects of craniosacral therapy and sensorimotor training on pain, disability, depression and quality of life of patients with nonspecific chronic low back pain: a randomized clinical trial. APIC 2021;25. https:\/\/doi.org\/10.35975\/apic.v25i2.1458.","DOI":"10.35975\/apic.v25i2.1458"},{"key":"2026102213580748958_j_jom-2025-0214_ref_023","doi-asserted-by":"crossref","unstructured":"Matar\u00e1n-Pe\u00f1arrocha, GA, Castro-S\u00e1nchez, AM, Garc\u00eda, GC, Moreno-Lorenzo, C, Carre\u00f1o, TP, Zafra, MDO. Influence of craniosacral therapy on anxiety, depression and quality of life in patients with fibromyalgia. Evid Based Complement Alternat Med 2011;2011:178769. https:\/\/doi.org\/10.1093\/ecam\/nep125.","DOI":"10.1093\/ecam\/nep125"},{"key":"2026102213580748958_j_jom-2025-0214_ref_024","doi-asserted-by":"crossref","unstructured":"Jain, S, McMahon, GF, Hasen, P, Kozub, MP, Porter, V, King, R, et al.. Healing touch with guided imagery for PTSD in returning active duty military: a randomized controlled trial. Mil Med 2012;177:1015\u201321. https:\/\/doi.org\/10.7205\/milmed-d-11-00290.","DOI":"10.7205\/MILMED-D-11-00290"},{"key":"2026102213580748958_j_jom-2025-0214_ref_025","doi-asserted-by":"crossref","unstructured":"Marta, IER, Baldan, SS, Berton, AF, Pavam, M, Silva, MJPD. The effectiveness of therapeutic touch on pain, depression and sleep in patients with chronic pain: clinical trial. Rev Esc Enferm USP 2010;44:1100\u20136. https:\/\/doi.org\/10.1590\/s0080-62342010000400035.","DOI":"10.1590\/S0080-62342010000400035"},{"key":"2026102213580748958_j_jom-2025-0214_ref_026","doi-asserted-by":"crossref","unstructured":"Potter, PJ. Breast biopsy and distress: feasibility of testing a Reiki intervention. J\u00a0Holist Nurs 2007;25:238\u201348. https:\/\/doi.org\/10.1177\/0898010107301618.","DOI":"10.1177\/0898010107301618"},{"key":"2026102213580748958_j_jom-2025-0214_ref_027","doi-asserted-by":"crossref","unstructured":"Rexilius, SJ, Mundt, CA, Megel, ME, Agrawal, S. Therapeutic effects of massage therapy and healing touch on caregivers of patients undergoing autologous hematopoietic stem cell transplant. Oncol Nurs Forum 2002;29:E35\u201344. https:\/\/doi.org\/10.1188\/02.onf.e35-e44.","DOI":"10.1188\/02.ONF.E35-E44"},{"key":"2026102213580748958_j_jom-2025-0214_ref_028","doi-asserted-by":"crossref","unstructured":"Richeson, NE, Spross, JA, Lutz, K, Peng, C. Effects of Reiki on anxiety, depression, pain, and physiological factors in community-dwelling older adults. Res Gerontol Nurs 2010;3:187\u201399. https:\/\/doi.org\/10.3928\/19404921-20100601-01.","DOI":"10.3928\/19404921-20100601-01"},{"key":"2026102213580748958_j_jom-2025-0214_ref_029","doi-asserted-by":"crossref","unstructured":"Rupert, RL, McKinzie, CL, Morter, MT, Daniel, DM. Treatment of chronic nonresponsive patients with a nonforce technique. J\u00a0Manipulative Physiol Therapeut 2005;28:259\u201364. https:\/\/doi.org\/10.1016\/j.jmpt.2005.03.013.","DOI":"10.1016\/j.jmpt.2005.03.013"},{"key":"2026102213580748958_j_jom-2025-0214_ref_030","unstructured":"Shore, AG. Long-term effects of energetic healing on symptoms of psychological depression and self-perceived stress. Alternative Ther Health Med 2004;10:42\u20138."},{"key":"2026102213580748958_j_jom-2025-0214_ref_031","doi-asserted-by":"crossref","unstructured":"Weze, C, Leathard, HL, Grange, J, Tiplady, P, Stevens, G. Healing by gentle touch ameliorates stress and other symptoms in people suffering with mental health disorders or psychological stress. Evid Based Complement Alternat Med 2007;4:115\u201323. https:\/\/doi.org\/10.1093\/ecam\/nel052.","DOI":"10.1093\/ecam\/nel052"},{"key":"2026102213580748958_j_jom-2025-0214_ref_032","doi-asserted-by":"crossref","unstructured":"Zins, S, Hooke, MC, Gross, CR. Reiki for pain during hemodialysis: a feasibility and instrument evaluation study. J\u00a0Holist Nurs 2019;37:148\u201362. https:\/\/doi.org\/10.1177\/0898010118797195.","DOI":"10.1177\/0898010118797195"},{"key":"2026102213580748958_j_jom-2025-0214_ref_033","doi-asserted-by":"crossref","unstructured":"Bearne, LM, Hurley, MV. Chapter 8 \u2013 physical therapies: treatment options in rheumatology. In: Dziedzic, K, Hammond, A, editors. Rheumatology. Washington D.C.: Churchill Livingstone; 2010:111\u201322 pp.","DOI":"10.1016\/B978-0-443-06934-5.00008-5"},{"key":"2026102213580748958_j_jom-2025-0214_ref_034","doi-asserted-by":"crossref","unstructured":"Alansari, SM, Youssef, EF, Shanb, AA. Efficacy of manual therapy on psychological status and pain in patients with neck pain: a randomized clinical trial. SMJ 2021;42:82\u201390. https:\/\/doi.org\/10.15537\/smj.2021.1.25589.","DOI":"10.15537\/smj.2021.1.25589"},{"key":"2026102213580748958_j_jom-2025-0214_ref_035","doi-asserted-by":"crossref","unstructured":"Castro-S\u00e1nchez, AM, Aguilar-Ferr\u00e1ndiz, ME, Matar\u00e1n-Pe\u00f1arrocha, GA, S\u00e1nchez-Joya, MDM, Arroyo-Morales, M, Fern\u00e1ndez-de-las-Pe\u00f1as, C. Short-term effects of a manual therapy protocol on pain, physical function, quality of sleep, depressive symptoms, and pressure sensitivity in women and men with fibromyalgia syndrome: a randomized controlled trial. Clin J Pain 2014;30:589\u201397. https:\/\/doi.org\/10.1097\/ajp.0000000000000008.","DOI":"10.1097\/AJP.0000000000000008"},{"key":"2026102213580748958_j_jom-2025-0214_ref_036","doi-asserted-by":"crossref","unstructured":"Dayan\u0131r, IO, Birinci, T, Kaya Mutlu, E, Akcetin, MA, Akdemir, AO. Comparison of three manual therapy techniques as trigger point therapy for chronic nonspecific low back pain: a randomized controlled pilot trial. J\u00a0Alternative Compl Med 2020;26:291\u20139. https:\/\/doi.org\/10.1089\/acm.2019.0435.","DOI":"10.1089\/acm.2019.0435"},{"key":"2026102213580748958_j_jom-2025-0214_ref_037","doi-asserted-by":"crossref","unstructured":"Delgado De La Serna, P, Plaza-Manzano, G, Cleland, J, Fern\u00e1ndez-de-las-Pe\u00f1as, C, Mart\u00edn-Casas, P, D\u00edaz-Arribas, MJ. Effects of cervico-mandibular manual therapy in patients with temporomandibular pain disorders and associated somatic tinnitus: a randomized clinical trial. Pain Med 2020;21:613\u201324. https:\/\/doi.org\/10.1093\/pm\/pnz278.","DOI":"10.1093\/pm\/pnz278"},{"key":"2026102213580748958_j_jom-2025-0214_ref_038","doi-asserted-by":"crossref","unstructured":"Engel, RM, Gonski, P, Vemulpad, S, Graham, PL. The long-term benefit of exercise with and without manual therapy for mild chronic obstructive pulmonary disease: a randomized controlled trial. J\u00a0Cardpulm Rehabil Prev 2024;44:257\u201365. https:\/\/doi.org\/10.1097\/hcr.0000000000000871.","DOI":"10.1097\/HCR.0000000000000871"},{"key":"2026102213580748958_j_jom-2025-0214_ref_039","doi-asserted-by":"crossref","unstructured":"Esp\u00ed-L\u00f3pez, GV, L\u00f3pez-Bueno, L, Vicente-Herrero, MT, Martinez-Arnau, FM, Monzani, L. Efficacy of manual therapy on anxiety and depression in patients with tension-type headache. A randomized controlled clinical trial. Int J Osteopath Med 2016;22:11\u201320. https:\/\/doi.org\/10.1016\/j.ijosm.2016.05.003.","DOI":"10.1016\/j.ijosm.2016.05.003"},{"key":"2026102213580748958_j_jom-2025-0214_ref_040","doi-asserted-by":"crossref","unstructured":"Moustafa, IM, Diab, AA. The addition of upper cervical manipulative therapy in the treatment of patients with fibromyalgia: a randomized controlled trial. Rheumatol Int 2015;35:1163\u201374. https:\/\/doi.org\/10.1007\/s00296-015-3248-7.","DOI":"10.1007\/s00296-015-3248-7"},{"key":"2026102213580748958_j_jom-2025-0214_ref_041","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-G\u00f3mez, E, Serra-A\u00f1\u00f3, P, Moll\u00e0-Casanova, S, Sempere-Rubio, N, Aguilar-Rodr\u00edguez, M, Esp\u00ed-L\u00f3pez, GV, et al.. Potential add-on effects of manual therapy techniques in migraine patients: a randomised controlled trial. JCM 2022;11:4686. https:\/\/doi.org\/10.3390\/jcm11164686.","DOI":"10.3390\/jcm11164686"},{"key":"2026102213580748958_j_jom-2025-0214_ref_042","doi-asserted-by":"crossref","unstructured":"Pioch, E, Niemier, K, Seidel, W. Manual medicine in the treatment of chronic musculoskeletal pain syndromes: evaluation of an inpatient treatment programme. J\u00a0Orthop Med 2006;28:4\u201312. https:\/\/doi.org\/10.1080\/1355297x.2006.11736279.","DOI":"10.1080\/1355297X.2006.11736279"},{"key":"2026102213580748958_j_jom-2025-0214_ref_043","doi-asserted-by":"crossref","unstructured":"Ta\u015fkaya, B, Ta\u015fkent, \u0130, \u00c7ak\u0131ll\u0131, M, Y\u0131lmaz, \u00d6. The effect of manual therapy on psychological factors and quality of life in lumbar disc herniation patients: a single blinded randomized clinical trial. IJERPH 2024;21:1234. https:\/\/doi.org\/10.3390\/ijerph21091234.","DOI":"10.3390\/ijerph21091234"},{"key":"2026102213580748958_j_jom-2025-0214_ref_044","doi-asserted-by":"crossref","unstructured":"Teychenne, M, Lamb, KE, Main, L, Miller, C, Hahne, A, Ford, J, et al.. General strength and conditioning versus motor control with manual therapy for improving depressive symptoms in chronic low back pain: a randomised feasibility trial. PLoS One 2019;14:e0220442. https:\/\/doi.org\/10.1371\/journal.pone.0220442.","DOI":"10.1371\/journal.pone.0220442"},{"key":"2026102213580748958_j_jom-2025-0214_ref_045","doi-asserted-by":"crossref","unstructured":"Wand, BM, Bird, C, McAuley, JH, Dor\u00e9, CJ, MacDowell, M, De Souza, LH. Early intervention for the management of acute low back pain: a single-blind randomized controlled trial of biopsychosocial education, manual therapy, and exercise. Spine 2004;29:2350\u20136. https:\/\/doi.org\/10.1097\/01.brs.0000143619.34308.b4.","DOI":"10.1097\/01.brs.0000143619.34308.b4"},{"key":"2026102213580748958_j_jom-2025-0214_ref_046","doi-asserted-by":"crossref","unstructured":"Cholewicki, J, Popovich, JMJr, Reeves, NP, DeStefano, LA, Rowan, JJ, Francisco, TJ, et al.. The effects of osteopathic manipulative treatment on pain and disability in patients with chronic neck pain: a single\u2010blinded randomized controlled trial. PM R 2022;14:1417\u201329. https:\/\/doi.org\/10.1002\/pmrj.12732.","DOI":"10.1002\/pmrj.12732"},{"key":"2026102213580748958_j_jom-2025-0214_ref_047","doi-asserted-by":"crossref","unstructured":"Cordano, C, Armezzani, A, Veroni, J, Pardini, M, Sassos, D, Infante, MT, et al.. Osteopathic manipulative therapy and multiple sclerosis: a proof-of-concept study. J\u00a0Osteopath Med 2018;118:531\u20136. https:\/\/doi.org\/10.7556\/jaoa.2018.121.","DOI":"10.7556\/jaoa.2018.121"},{"key":"2026102213580748958_j_jom-2025-0214_ref_048","doi-asserted-by":"crossref","unstructured":"De Oliveira Meirelles, F, De Oliveira Muniz Cunha, JC, Da Silva, EB. Osteopathic manipulation treatment versus therapeutic exercises in patients with chronic nonspecific low back pain: a randomized, controlled and double-blind study. BMR 2020;33:367\u201377. https:\/\/doi.org\/10.3233\/bmr-181355.","DOI":"10.3233\/BMR-181355"},{"key":"2026102213580748958_j_jom-2025-0214_ref_049","doi-asserted-by":"crossref","unstructured":"D\u2019Ippolito, M, Tramontano, M, Buzzi, MG. Effects of osteopathic manipulative therapy on pain and mood disorders in patients with high-frequency migraine. J\u00a0Osteopath Med 2017;117:365\u20139. https:\/\/doi.org\/10.7556\/jaoa.2017.074.","DOI":"10.7556\/jaoa.2017.074"},{"key":"2026102213580748958_j_jom-2025-0214_ref_050","doi-asserted-by":"crossref","unstructured":"Florance, BM, Frin, G, Dainese, R, N\u00e9bot-Vivinus, MH, Marine Barjoan, E, Marjoux, S, et al.. Osteopathy improves the severity of irritable bowel syndrome: a pilot randomized sham-controlled study. Eur J Gastroenterol Hepatol 2012;24:944\u20139. https:\/\/doi.org\/10.1097\/meg.0b013e3283543eb7.","DOI":"10.1097\/MEG.0b013e3283543eb7"},{"key":"2026102213580748958_j_jom-2025-0214_ref_051","unstructured":"Gamber, RG, Shores, JH, Russo, DP, Jimenez, C, Rubin, BR. Osteopathic manipulative treatment in conjunction with medication relieves pain associated with fibromyalgia syndrome: results of a randomized clinical pilot project. J\u00a0Am Osteopath Assoc 2002;102:321\u20135."},{"key":"2026102213580748958_j_jom-2025-0214_ref_052","doi-asserted-by":"crossref","unstructured":"Hope-Bell, J, Draper-Rodi, J, Edwards, DJ. Applying an osteopathic intervention to improve mild to moderate mental health symptoms: a mixed-methods feasibility randomised trial. Chiropr Man Ther 2024;32. https:\/\/doi.org\/10.1186\/s12998-024-00556-x.","DOI":"10.1186\/s12998-024-00556-x"},{"key":"2026102213580748958_j_jom-2025-0214_ref_053","doi-asserted-by":"crossref","unstructured":"Miranda, E, Giza, J, Feketeova, E, Castro-Nunez, C, Vieux, U, Huynh, MD. Osteopathic manipulative treatment in patients with anxiety and depression: a pilot study. AAO J 2021;31:9\u201316. https:\/\/doi.org\/10.53702\/2375-5717-31.3.9.","DOI":"10.53702\/2375-5717-31.3.9"},{"key":"2026102213580748958_j_jom-2025-0214_ref_054","unstructured":"Plotkin, BJ, Rodos, JJ, Kappler, R, Schrage, M, Freydl, K, Hasegawa, S, et al.. Adjunctive osteopathic manipulative treatment in women with depression: a pilot study. J\u00a0Osteopath Med 2001;101:517\u201323. https:\/\/doi.org\/10.7556\/jaoa.2001.101.9.517."},{"key":"2026102213580748958_j_jom-2025-0214_ref_055","doi-asserted-by":"crossref","unstructured":"Wiegand, S, Bianchi, W, Quinn, TA, Best, M, Fotopoulos, T. Osteopathic manipulative treatment for self-reported fatigue, stress, and depression in first-year osteopathic medical students. J\u00a0Osteopath Med 2015;115:84\u201393. https:\/\/doi.org\/10.7556\/jaoa.2015.019.","DOI":"10.7556\/jaoa.2015.019"},{"key":"2026102213580748958_j_jom-2025-0214_ref_056","doi-asserted-by":"crossref","unstructured":"Hughes, C, Smyth, S, Lowe-Strong, A. Reflexology for the treatment of pain in people with multiple sclerosis: a double-blind randomised sham-controlled clinical trial. Mult Scler 2009;15:1329\u201338. https:\/\/doi.org\/10.1177\/1352458509345916.","DOI":"10.1177\/1352458509345916"},{"key":"2026102213580748958_j_jom-2025-0214_ref_057","doi-asserted-by":"crossref","unstructured":"Mahdavipour, F, Rahemi, Z, Sadat, Z, Ajorpaz, NM. The effects of foot reflexology on depression during menopause: a randomized controlled clinical trial. Compl Ther Med 2019;47:102195. https:\/\/doi.org\/10.1016\/j.ctim.2019.102195.","DOI":"10.1016\/j.ctim.2019.102195"},{"key":"2026102213580748958_j_jom-2025-0214_ref_058","doi-asserted-by":"crossref","unstructured":"Sharp, DM, Walker, MB, Chaturvedi, A, Upadhyay, S, Hamid, A, Walker, AA, et al.. A randomised, controlled trial of the psychological effects of reflexology in early breast cancer. Eur J Cancer 2010;46:312\u201322. https:\/\/doi.org\/10.1016\/j.ejca.2009.10.006.","DOI":"10.1016\/j.ejca.2009.10.006"},{"key":"2026102213580748958_j_jom-2025-0214_ref_059","unstructured":"Ajilchi, B, Amini, H, Kargar, F, Jamali, S. The effectiveness of massage therapy on reducing depression in students. Indian J Fundam Appl Life Sci 2015;5:1937\u201342."},{"key":"2026102213580748958_j_jom-2025-0214_ref_060","doi-asserted-by":"crossref","unstructured":"Alnigenis, MNY, Bradley, JD, Wallick, J, Emsley, CL. Massage therapy in the management of fibromyalgia: a pilot study. J\u00a0Muscoskel Pain 2001;9:55\u201367. https:\/\/doi.org\/10.1300\/j094v09n02_05.","DOI":"10.1300\/J094v09n02_05"},{"key":"2026102213580748958_j_jom-2025-0214_ref_061","doi-asserted-by":"crossref","unstructured":"Arnold, MM, M\u00fcller-Oerlinghausen, B, Hemrich, N, B\u00f6nsch, D. Effects of psychoactive massage in outpatients with depressive disorders: a randomized controlled mixed-methods study. Brain Sci 2020;10:676. https:\/\/doi.org\/10.3390\/brainsci10100676.","DOI":"10.3390\/brainsci10100676"},{"key":"2026102213580748958_j_jom-2025-0214_ref_062","doi-asserted-by":"crossref","unstructured":"Bahrami, T, Rejeh, N, Heravi\u2010Karimooi, M, Vaismoradi, M, Tadrisi, SD, Sieloff, C. Effect of aromatherapy massage on anxiety, depression, and physiologic parameters in older patients with the acute coronary syndrome: a randomized clinical trial. Int J Nurs Pract 2017;23. https:\/\/doi.org\/10.1111\/ijn.12601.","DOI":"10.1111\/ijn.12601"},{"key":"2026102213580748958_j_jom-2025-0214_ref_063","doi-asserted-by":"crossref","unstructured":"Baumgart, SBE, Baumbach-Kraft, A, Lorenz, J. Effect of psycho-regulatory massage therapy on pain and depression in women with chronic and\/or somatoform back pain: a randomized controlled trial. Brain Sci 2020;10:721. https:\/\/doi.org\/10.3390\/brainsci10100721.","DOI":"10.3390\/brainsci10100721"},{"key":"2026102213580748958_j_jom-2025-0214_ref_064","doi-asserted-by":"crossref","unstructured":"Billhult, A, Lindholm, C, Gunnarsson, R, Stener-Victorin, E. The effect of massage on cellular immunity, endocrine and psychological factors in women with breast cancer\u00a0\u2013\u00a0a randomized controlled clinical trial. Auton Neurosci 2008;140:88\u201395. https:\/\/doi.org\/10.1016\/j.autneu.2008.03.006.","DOI":"10.1016\/j.autneu.2008.03.006"},{"key":"2026102213580748958_j_jom-2025-0214_ref_065","doi-asserted-by":"crossref","unstructured":"Billhult, A, Bergbom, I, Stener-Victorin, E. Massage relieves nausea in women with breast cancer who are undergoing chemotherapy. J\u00a0Alternative Compl Med 2007;13:53\u20138. https:\/\/doi.org\/10.1089\/acm.2006.6049.","DOI":"10.1089\/acm.2006.6049"},{"key":"2026102213580748958_j_jom-2025-0214_ref_066","doi-asserted-by":"crossref","unstructured":"Chase, T, Jha, A, Brooks, CA, Allshouse, A. A pilot feasibility study of massage to reduce pain in people with spinal cord injury during acute rehabilitation. Spinal Cord 2013;51:847\u201351. https:\/\/doi.org\/10.1038\/sc.2013.104.","DOI":"10.1038\/sc.2013.104"},{"key":"2026102213580748958_j_jom-2025-0214_ref_067","doi-asserted-by":"crossref","unstructured":"Chen, Y, Sun, XY, Qian, C, Zhang, XX, Zhou, YJ, Zhang, HY, et al.. Therapeutic effect of manual massage on early postpartum rectus abdominis separation and postpartum depression. World J Psychiatr 2024;14:678\u201385. https:\/\/doi.org\/10.5498\/wjp.v14.i5.678.","DOI":"10.5498\/wjp.v14.i5.678"},{"key":"2026102213580748958_j_jom-2025-0214_ref_068","doi-asserted-by":"crossref","unstructured":"Da Rocha Rodrigues, G, Bollondi Pauly, C, Boegli, M, Curtin, F, Anex, A, Cekic, S, et al.. Impacts of touch massage on the experience of patients with chronic pain: a non-randomized cluster clinical trial. Adv Integr Med 2023;10:145\u201351. https:\/\/doi.org\/10.1016\/j.aimed.2023.09.004.","DOI":"10.1016\/j.aimed.2023.09.004"},{"key":"2026102213580748958_j_jom-2025-0214_ref_069","doi-asserted-by":"crossref","unstructured":"Diego, MA, Field, T, Hernandez-Reif, M, Hart, S, Brucker, B, Field, T, et al.. Spinal cord patients benefit from massage therapy. Int J Neurosci 2002;112:133\u201342. https:\/\/doi.org\/10.1080\/00207450212023.","DOI":"10.1080\/00207450212023"},{"key":"2026102213580748958_j_jom-2025-0214_ref_070","doi-asserted-by":"crossref","unstructured":"Donoyama, N, Satoh, T, Hamano, T, Ohkoshi, N, Onuki, M. Effects of Anma therapy (Japanese massage) on health-related quality of life in gynecologic cancer survivors: a randomized controlled trial. PLoS One 2018;13:e0196638. https:\/\/doi.org\/10.1371\/journal.pone.0196638.","DOI":"10.1371\/journal.pone.0196638"},{"key":"2026102213580748958_j_jom-2025-0214_ref_071","doi-asserted-by":"crossref","unstructured":"Field, T, Morrow, C, Valdeon, C, Larson, S, Kuhn, C, Schanberg, S. Massage reduces anxiety in child and adolescent psychiatric patients. J\u00a0Am Acad Child Adolesc Psychiatry 1992;31:125\u201331. https:\/\/doi.org\/10.1097\/00004583-199201000-00019.","DOI":"10.1097\/00004583-199201000-00019"},{"key":"2026102213580748958_j_jom-2025-0214_ref_072","doi-asserted-by":"crossref","unstructured":"Field, T, Diego, M, Hernandez-Reif, M, Medina, L, Delgado, J, Hernandez, A. Yoga and massage therapy reduce prenatal depression and prematurity. J\u00a0Bodyw Mov Ther 2012;16:204\u20139. https:\/\/doi.org\/10.1016\/j.jbmt.2011.08.002.","DOI":"10.1016\/j.jbmt.2011.08.002"},{"key":"2026102213580748958_j_jom-2025-0214_ref_073","doi-asserted-by":"crossref","unstructured":"Field, T, Deeds, O, Diego, M, Hernandez-Reif, M, Gauler, A, Sullivan, S, et al.. Benefits of combining massage therapy with group interpersonal psychotherapy in prenatally depressed women. J\u00a0Bodyw Mov Ther 2009;13:297\u2013303. https:\/\/doi.org\/10.1016\/j.jbmt.2008.10.002.","DOI":"10.1016\/j.jbmt.2008.10.002"},{"key":"2026102213580748958_j_jom-2025-0214_ref_074","doi-asserted-by":"crossref","unstructured":"Field, T, Hernandez-Reif, M, Diego, M, Fraser, M. Lower back pain and sleep disturbance are reduced following massage therapy. J\u00a0Bodyw Mov Ther 2007;11:141\u20135. https:\/\/doi.org\/10.1016\/j.jbmt.2006.03.001.","DOI":"10.1016\/j.jbmt.2006.03.001"},{"key":"2026102213580748958_j_jom-2025-0214_ref_075","doi-asserted-by":"crossref","unstructured":"Garner, B, Phillips, LJ, Schmidt, HM, Markulev, C, O\u2019Connor, J, Wood, SJ, et al.. Pilot study evaluating the effect of massage therapy on stress, anxiety and aggression in a young adult psychiatric inpatient unit. Aust N Z J Psychiatr 2008;42:414\u201322. https:\/\/doi.org\/10.1080\/00048670801961131.","DOI":"10.1080\/00048670801961131"},{"key":"2026102213580748958_j_jom-2025-0214_ref_076","doi-asserted-by":"crossref","unstructured":"Hernandez-Reif, M, Ironson, G, Field, T, Hurley, J, Katz, G, Diego, M, et al.. Breast cancer patients have improved immune and neuroendocrine functions following massage therapy. J\u00a0Psychosom Res 2004;57:45\u201352. https:\/\/doi.org\/10.1016\/s0022-3999(03)00500-2.","DOI":"10.1016\/S0022-3999(03)00500-2"},{"key":"2026102213580748958_j_jom-2025-0214_ref_077","doi-asserted-by":"crossref","unstructured":"Hernandez-Reif, M, Field, T, Krasnegor, J, Theakston, H. Lower back pain is reduced and range of motion increased after massage therapy. Int J Neurosci 2001;106:131\u201345. https:\/\/doi.org\/10.3109\/00207450109149744.","DOI":"10.3109\/00207450109149744"},{"key":"2026102213580748958_j_jom-2025-0214_ref_078","doi-asserted-by":"crossref","unstructured":"Hernandez-Reif, M, Field, T, Ironson, G, Beutler, J, Vera, Y, Hurley, J, et al.. Natural killer cells and lymphocytes increase in women with breast cancer following massage therapy. Int J Neurosci 2005;115:495\u2013510. https:\/\/doi.org\/10.1080\/00207450590523080.","DOI":"10.1080\/00207450590523080"},{"key":"2026102213580748958_j_jom-2025-0214_ref_079","doi-asserted-by":"crossref","unstructured":"Hirakawa, Y, Masuda, Y, Kimata, T, Uemura, K, Kuzuya, M, Iguchi, A. Effects of home massage rehabilitation therapy for the bed-ridden elderly: a pilot trial with a three-month follow-up. Clin Rehabil 2005;19:20\u20137. https:\/\/doi.org\/10.1191\/0269215505cr795oa.","DOI":"10.1191\/0269215505cr795oa"},{"key":"2026102213580748958_j_jom-2025-0214_ref_080","doi-asserted-by":"crossref","unstructured":"Huanan, L, Jingui, W, Wei, Z, Na, Z, Xinhua, H, Shiquan, S, et al.. Chronic fatigue syndrome treated by the traditional Chinese procedure abdominal tuina: a randomized controlled clinical trial. J\u00a0Tradit Chin Med 2017;37:819\u201326. https:\/\/doi.org\/10.1016\/s0254-6272(18)30046-3.","DOI":"10.1016\/S0254-6272(18)30046-3"},{"key":"2026102213580748958_j_jom-2025-0214_ref_081","doi-asserted-by":"crossref","unstructured":"Krohn, M, Listing, M, Tjahjono, G, Reisshauer, A, Peters, E, Klapp, BF, et al.. Depression, mood, stress, and Th1\/Th2 immune balance in primary breast cancer patients undergoing classical massage therapy. Support Care Cancer 2011;19:1303\u201311. https:\/\/doi.org\/10.1007\/s00520-010-0946-2.","DOI":"10.1007\/s00520-010-0946-2"},{"key":"2026102213580748958_j_jom-2025-0214_ref_082","doi-asserted-by":"crossref","unstructured":"Kuriyama, H, Watanabe, S, Nakaya, T, Shigemori, I, Kita, M, Yoshida, N, et al.. Immunological and psychological benefits of aromatherapy massage. Evid Based Complement Alternat Med 2005;2:179\u201384. https:\/\/doi.org\/10.1093\/ecam\/neh087.","DOI":"10.1093\/ecam\/neh087"},{"key":"2026102213580748958_j_jom-2025-0214_ref_083","doi-asserted-by":"crossref","unstructured":"Moraska, A, Chandler, C. Changes in psychological parameters in patients with tension-type headache following massage therapy: a pilot study. J\u00a0Man Manip Ther 2009;17:86\u201394. https:\/\/doi.org\/10.1179\/106698109790824695.","DOI":"10.1179\/106698109790824695"},{"key":"2026102213580748958_j_jom-2025-0214_ref_084","doi-asserted-by":"crossref","unstructured":"Naderi, A, Rezvani, MH, Aminian\u2010Far, A, Hamood-Ahvazi, S. Can a six-week Swedish massage reduce mood disorders and enhance the quality of life in individuals with multiple sclerosis? A randomized control clinical trial. Explore 2024;20:103032. https:\/\/doi.org\/10.1016\/j.explore.2024.103032.","DOI":"10.1016\/j.explore.2024.103032"},{"key":"2026102213580748958_j_jom-2025-0214_ref_085","doi-asserted-by":"crossref","unstructured":"Okamoto, A, Kuriyama, H, Watanabe, S, Aihara, Y, Tadai, T, Imanishi, J, et al.. The effect of aromatherapy massage on mild depression: a pilot study. Psychiatr Clin Neurosci 2005;59:363. https:\/\/doi.org\/10.1111\/j.1440-1819.2005.01385.x.","DOI":"10.1111\/j.1440-1819.2005.01385.x"},{"key":"2026102213580748958_j_jom-2025-0214_ref_086","doi-asserted-by":"crossref","unstructured":"Piri, E, Ghasemi, B, Shafizadeh, A. Comparison of the effects of the three methods of massage, selected yoga exercises and massage-yoga combination on the depression in elderly women. Baltic J Health Phys Act 2023;15:4. https:\/\/doi.org\/10.29359\/bjhpa.15.4.04.","DOI":"10.29359\/BJHPA.15.4.04"},{"key":"2026102213580748958_j_jom-2025-0214_ref_087","doi-asserted-by":"crossref","unstructured":"Poland, RE, Gertsik, L, Favreau, JT, Smith, SI, Mirocha, JM, Rao, U, et al.. Open-label, randomized, parallel-group controlled clinical trial of massage for treatment of depression in HIV-infected subjects. J\u00a0Alternative Compl Med 2013;19:334\u201340. https:\/\/doi.org\/10.1089\/acm.2012.0058.","DOI":"10.1089\/acm.2012.0058"},{"key":"2026102213580748958_j_jom-2025-0214_ref_088","doi-asserted-by":"crossref","unstructured":"Puustj\u00e4rvi, K, Airaksinen, O, P\u00f6ntinen, PJ. The effects of massage in patients with chronic tension headache. Acupunct Electro-Ther Res 1990;15:159\u201362. https:\/\/doi.org\/10.3727\/036012990816358234.","DOI":"10.3727\/036012990816358234"},{"key":"2026102213580748958_j_jom-2025-0214_ref_089","doi-asserted-by":"crossref","unstructured":"Rahimian Bougar, M, Veiskarami, HA, Khodarahimi, S, Izadpanah, A, Sadeghi, M, Nazari, N. Effectiveness of three physical treatments on pain perception and emotional state in males with chronic joint pain. J\u00a0Clin Psychol Med Settings 2022;29:785\u201397. https:\/\/doi.org\/10.1007\/s10880-021-09835-8.","DOI":"10.1007\/s10880-021-09835-8"},{"key":"2026102213580748958_j_jom-2025-0214_ref_090","doi-asserted-by":"crossref","unstructured":"Reychler, G, Caty, G, Arcq, A, Lebrun, L, Belkhir, L, Yombi, JC, et al.. Effects of massage therapy on anxiety, depression, hyperventilation and quality of life in HIV infected patients: a randomized controlled trial. Compl Ther Med 2017;32:109\u201314. https:\/\/doi.org\/10.1016\/j.ctim.2017.05.002.","DOI":"10.1016\/j.ctim.2017.05.002"},{"key":"2026102213580748958_j_jom-2025-0214_ref_091","doi-asserted-by":"crossref","unstructured":"Roh, YS, Cho, H, Oh, JO, Yoon, CJ. Effects of skin rehabilitation massage therapy on pruritus, skin status, and depression in burn survivors. J\u00a0Korean Acad Nurs 2007;37:221. https:\/\/doi.org\/10.4040\/jkan.2007.37.2.221.","DOI":"10.4040\/jkan.2007.37.2.221"},{"key":"2026102213580748958_j_jom-2025-0214_ref_092","doi-asserted-by":"crossref","unstructured":"Serfaty, M, Wilkinson, S, Freeman, C, Mannix, K, King, M. The ToT study: helping with touch or talk (ToT): a pilot randomised controlled trial to examine the clinical effectiveness of aromatherapy massage versus cognitive behaviour therapy for emotional distress in patients in cancer\/palliative care. Psychooncology 2012;21:563\u20139. https:\/\/doi.org\/10.1002\/pon.1921.","DOI":"10.1002\/pon.1921"},{"key":"2026102213580748958_j_jom-2025-0214_ref_093","doi-asserted-by":"crossref","unstructured":"Soden, K, Vincent, K, Craske, S, Lucas, C, Ashley, S. A randomized controlled trial of aromatherapy massage in a hospice setting. Palliat Med 2004;18:87\u201392. https:\/\/doi.org\/10.1191\/0269216304pm874oa.","DOI":"10.1191\/0269216304pm874oa"},{"key":"2026102213580748958_j_jom-2025-0214_ref_094","doi-asserted-by":"crossref","unstructured":"Taavoni, S, Darsareh, F, Joolaee, S, Haghani, H. The effect of aromatherapy massage on the psychological symptoms of\u00a0postmenopausal Iranian women. Compl Ther Med 2013;21:158\u201363. https:\/\/doi.org\/10.1016\/j.ctim.2013.03.007.","DOI":"10.1016\/j.ctim.2013.03.007"},{"key":"2026102213580748958_j_jom-2025-0214_ref_095","doi-asserted-by":"crossref","unstructured":"Thanakiatpinyo, T, Kuptniratsaikul, V, Suwanatrai, S, Khumkaew, P, Wiwattamongkol, D, Vannabhum, M, et al.. The efficacy of traditional Thai massage in decreasing spasticity in elderly stroke patients. CIA 2014;1311. https:\/\/doi.org\/10.2147\/cia.s66416.","DOI":"10.2147\/CIA.S66416"},{"key":"2026102213580748958_j_jom-2025-0214_ref_096","doi-asserted-by":"crossref","unstructured":"Walach, H, G\u00fcthlin, C, K\u00f6nig, M. Efficacy of massage therapy in chronic pain: a pragmatic randomized trial. J\u00a0Alternative Compl Med 2003;9:837\u201346. https:\/\/doi.org\/10.1089\/107555303771952181.","DOI":"10.1089\/107555303771952181"},{"key":"2026102213580748958_j_jom-2025-0214_ref_097","doi-asserted-by":"crossref","unstructured":"Wilkinson, SM, Love, SB, Westcombe, AM, Gambles, MA, Burgess, CC, Cargill, A, et al.. Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: a multicenter randomized controlled trial. JCO 2007;25:532\u20139. https:\/\/doi.org\/10.1200\/jco.2006.08.9987.","DOI":"10.1200\/JCO.2006.08.9987"},{"key":"2026102213580748958_j_jom-2025-0214_ref_098","doi-asserted-by":"crossref","unstructured":"Xiong, M, Li, Y, Tang, P, Zhang, Y, Cao, M, Ni, J, et al.. Effectiveness of aromatherapy massage and inhalation on symptoms of depression in Chinese community-dwelling older adults. J\u00a0Alternative Compl Med 2018;24:717\u201324. https:\/\/doi.org\/10.1089\/acm.2017.0320.","DOI":"10.1089\/acm.2017.0320"},{"key":"2026102213580748958_j_jom-2025-0214_ref_099","doi-asserted-by":"crossref","unstructured":"Xu, H, Zhao, C, Guo, G, Li, Y, A, X, Qiu, G, et al.. The effectiveness of tuina in relieving pain, negative emotions, and disability in knee osteoarthritis: a randomized controlled trial. Pain Med 2023;24:244\u201357. https:\/\/doi.org\/10.1093\/pm\/pnac127.","DOI":"10.1093\/pm\/pnac127"},{"key":"2026102213580748958_j_jom-2025-0214_ref_100","doi-asserted-by":"crossref","unstructured":"Yang, YP, Wang, CJ, Wang, JJ. Effect of aromatherapy massage on agitation and depressive mood in individuals with dementia. J\u00a0Gerontol Nurs 2016;42:38\u201346. https:\/\/doi.org\/10.3928\/00989134-20160615-03.","DOI":"10.3928\/00989134-20160615-03"},{"key":"2026102213580748958_j_jom-2025-0214_ref_101","doi-asserted-by":"crossref","unstructured":"Yang, YP, Lee, FP, Chao, HC, Hsu, FY, Wang, JJ. Comparing the effects of cognitive stimulation, reminiscence, and aroma-massage on agitation and depressive mood in people with dementia. J\u00a0Am Med Dir Assoc 2016;17:719\u201324. https:\/\/doi.org\/10.1016\/j.jamda.2016.03.021.","DOI":"10.1016\/j.jamda.2016.03.021"},{"key":"2026102213580748958_j_jom-2025-0214_ref_102","doi-asserted-by":"crossref","unstructured":"Castro-S\u00e1nchez, AM, Matar\u00e1n-Pe\u00f1arrocha, GA, Granero-Molina, J, Aguilera-Manrique, G, Quesada-Rubio, JM, Moreno-Lorenzo, C. Benefits of massage\u2010myofascial release therapy on pain, anxiety, quality of sleep, depression, and quality of life in patients with fibromyalgia. Evid Based Complement Alternat Med 2011;2011. https:\/\/doi.org\/10.1155\/2011\/561753.","DOI":"10.1155\/2011\/561753"},{"key":"2026102213580748958_j_jom-2025-0214_ref_103","doi-asserted-by":"crossref","unstructured":"Castro S\u00e1nchez, AM, Garc\u00eda L\u00f3pez, H, Fern\u00e1ndez S\u00e1nchez, M, P\u00e9rez M\u00e1rmol, JM, Aguilar-Ferr\u00e1ndiz, ME, Luque Su\u00e1rez, A, et al.. Improvement in clinical outcomes after dry needling versus myofascial release on pain pressure thresholds, quality of life, fatigue, pain intensity, quality of sleep, anxiety, and depression in patients with fibromyalgia syndrome. Disabil Rehabil 2019;41:2235\u201346. https:\/\/doi.org\/10.1080\/09638288.2018.1461259.","DOI":"10.1080\/09638288.2018.1461259"},{"key":"2026102213580748958_j_jom-2025-0214_ref_104","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-P\u00e9rez, AM, Peralta-Ram\u00edrez, MI, Pilat, A, Villaverde, C. Effects of myofascial induction techniques on physiologic and psychologic parameters: a randomized controlled trial. J\u00a0Alternative Compl Med 2008;14:807\u201311. https:\/\/doi.org\/10.1089\/acm.2008.0117.","DOI":"10.1089\/acm.2008.0117"},{"key":"2026102213580748958_j_jom-2025-0214_ref_105","doi-asserted-by":"crossref","unstructured":"Turksen, G, Kisa, EP, Kaya, BK, Muammer, K, Muammer, R. Effects of connective tissue massage and kinesiotaping in patients with fibromyalgia. J\u00a0Bodyw Mov Ther 2024;40:1020\u20136. https:\/\/doi.org\/10.1016\/j.jbmt.2024.07.009.","DOI":"10.1016\/j.jbmt.2024.07.009"},{"key":"2026102213580748958_j_jom-2025-0214_ref_106","doi-asserted-by":"crossref","unstructured":"Yagci, N, Senel, A, Atalay, OT, Akman, TC, Can, OK. Long-term follow-up result of connective tissue manipulation in young women with primary dysmenorrhea: different intervention durations. Reprod Sci 2023;30. https:\/\/doi.org\/10.1007\/s43032-023-01172-5.","DOI":"10.1007\/s43032-023-01172-5"}],"container-title":["Journal of Osteopathic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jom-2025-0214\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jom-2025-0214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:58:46Z","timestamp":1792677526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/jom-2025-0214\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":106,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,2,26]]},"published-print":{"date-parts":[[2026,10,23]]}},"alternative-id":["10.1515\/jom-2025-0214"],"URL":"https:\/\/doi.org\/10.1515\/jom-2025-0214","relation":{},"ISSN":["2702-3648"],"issn-type":[{"value":"2702-3648","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}