{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:19:41Z","timestamp":1780399181007,"version":"3.54.1"},"reference-count":51,"publisher":"Walter de Gruyter GmbH","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jom-2026-0018_abs_001\">\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The postacute sequelae of SARS-CoV-2 (PASC) are unexpected consequences of COVID-19 infections. Many patients continue to have PASC-related symptoms weeks to months after an infection, experiencing morbidity that affects daily living. Historically, many symptoms associated with PASC have been responsive to osteopathic manipulative medicine (OMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2026-0018_abs_002\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop and disseminate a standardized clinical protocol for evaluating the efficacy of osteopathic manipulative treatment (OMT) in managing PASC. This study will assess OMT\u2019s impact on symptoms and functional outcomes while systematically monitoring for adverse events (AEs) within this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2026-0018_abs_003\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol is a prospective, single-arm, pre-post treatment cohort study involving patients seeking OMT with PASC-related symptoms. Standardized outcome measures have been selected to assess PASC-related symptoms and lifestyle impact over a 6-month longitudinal period. Data collection will occur at enrollment (baseline), at every second OMT session, and at a final follow-up. This final assessment will be conducted either 6\u00a0months postenrollment or 2\u00a0months after the cessation of treatment, whichever occurs first. Pragmatic, personalized OMT based on the physicians\u2019 clinical findings and judgment is recommended to provide a realistic assessment of real-world OMT practice vs. a protocol-based intervention. The design developers recommend utilizing a web-based, HIPAA-compliant platform such as Research Electronic Data Capture (REDCap) to facilitate informed consent procedures, disperse and collect surveys, provide reminders for completing surveys, and store and manage\u00a0data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2026-0018_abs_004\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, participants will provide demographic and clinical data, including age, sex, race, smoking and employment status, pre-COVID-19 health status, and comorbidities. We will also document symptoms and treatments associated with their acute COVID-19 illness. Descriptive statistics will summarize baseline characteristics. Longitudinal outcomes\u00a0\u2013\u00a0encompassing neurocognitive function, physical symptoms, quality of life, and work status\u00a0\u2013\u00a0will be analyzed utilizing generalized linear mixed models (GLMMs). This approach accounts for clinician-level clustering and adjusts for potential confounding variables while monitoring for adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jom-2026-0018_abs_005\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This protocol provides a standardized, pragmatic framework to evaluate the impact of OMT on the multifaceted symptoms of PASC. By utilizing a longitudinal, real-world design and robust statistical modeling (GLMM), the study aims to establish evidence-based insights into how osteopathic intervention can improve functional outcomes and quality of life for PASC patients. Furthermore, this standardized approach facilitates multi-site collaboration, ensuring that findings are reproducible and scalable within the broader medical community.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/jom-2026-0018","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:59:58Z","timestamp":1780394398000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of osteopathic manipulative treatment in the management of persistent post-COVID-19 symptoms and functional outcomes: study protocol of a prospective pilot study"],"prefix":"10.1515","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3944-9230","authenticated-orcid":false,"given":"Brian F.","family":"Degenhardt","sequence":"first","affiliation":[{"name":"A.T. Still Research Institute and the Department of Osteopathic Manipulative Medicine , Kirksville College of Osteopathic Medicine, A.T. Still University , Kirksville , MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-3638","authenticated-orcid":false,"given":"Yasir","family":"Rehman","sequence":"additional","affiliation":[{"name":"Health Research Methodology and Michael G. DeGroote Institute for Pain Research and Care, McMaster University , Hamilton , Canada"},{"name":"Medical Sciences at the Canadian Academy of Osteopathy , Hamilton , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0067-3582","authenticated-orcid":false,"given":"Corey","family":"Luebbering","sequence":"additional","affiliation":[{"name":"A.T. Still Research Institute, A.T. Still University , Kirksville , MO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Divine","sequence":"additional","affiliation":[{"name":"Osteopathic Principles and Practice Department , A.T. Still University School of Osteopathic Medicine , Mesa , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jackson","sequence":"additional","affiliation":[{"name":"A.T. Still Research Institute, A.T. Still University , Mesa , AZ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026060210482387009_j_jom-2026-0018_ref_001","unstructured":"Centers for Disease Control and Prevention \u2013 COVID Data Tracker (CDC). 2023. https:\/\/www.cdc.gov\/covid\/php\/surveillance\/index.html [Accessed 16 Jan 2023]."},{"key":"2026060210482387009_j_jom-2026-0018_ref_002","doi-asserted-by":"crossref","unstructured":"Montoy, JCC, Ford, J, Yu, H, Gottlieb, M, Morse, D, Santangelo, M, et al.. Prevalence of symptoms\u00a0\u226412\u00a0months after acute illness, by COVID-19 testing status among adults\u00a0\u2013\u00a0United\u00a0States, December 2020\u2013March 2023. 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