{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T13:53:43Z","timestamp":1715176423017},"reference-count":35,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT) polymorphism and risk of preeclampsia (PE). The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA) complicating PE.<\/jats:p><jats:p>Methods: The study included 47 early-onset PE patients and 47 control cases. Forty-seven early-onset PE patients were grouped by disease severity (33 patients with a severe form and 14 patients without severe features) and secondly by size for gestational age (12 patients with appropriate-for-gestational-age (AGA) and 35 patients with SGA size). p.Val158Met polymorphism was genotyped by PCR-RFLP analysis.<\/jats:p><jats:p>Results: Allele analysis showed significant difference in COMT allele distribution between early-onset PE and control group as well as early-onset PE SGA and controls (p=0.04057 and p=0.0411 respectively). A statistically significant distribution difference between the severe form and form without severe features of early-onset PE patients was not observed (p&gt;0.05). The highest difference observed was in the allele recessive model where COMT MetMet genotype was associated with decreased risk of early-onset PE (OR=0.281; 95%CI=0.092-0.7836) and PE complications including severe early-onset PE (OR= 0.304; 95%CI=0.086-0.944) and SGA early-onset PE (OR=0.284; 95%CI=0.081-0.874).<\/jats:p><jats:p>Conclusions: COMT may be used as a candidate gene for early-onset PE and its severe form and SGA complications.<\/jats:p>","DOI":"10.1515\/jomb-2016-0013","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T17:35:00Z","timestamp":1461173700000},"page":"312-318","source":"Crossref","is-referenced-by-count":4,"title":["Protective Role of Maternal P.VAL158MET Catechol-O-methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications"],"prefix":"10.5937","volume":"35","author":[{"given":"Tijana","family":"Krnjeta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana","family":"Mirkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Ignjatovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Toma\u0161evi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Luki\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drina","family":"Topalov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Soldatovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Majki\u0107-Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref141","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/1471-0528.12259","article-title":"Cost and resource implications with serum angiogenic factor estimation in the triage of preeclampsia","volume":"120","author":"Schnettler","year":"2013","journal-title":"BJOG"},{"key":"ref311","first-page":"359","article-title":"Association between genetic variation in the gene for insulin - like growth factor - I and low birth weight","author":"Vaessen","year":"2002","journal-title":"Lancet"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1055\/s-2007-999669","article-title":"Catechol - - methyl transferase activity in the human term placenta","volume":"5","author":"Barnea","year":"1988","journal-title":"Am J Perinatol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000097926","article-title":"Candidate gene association study of mothers with pre - eclampsia , and their infants , analyzing SNPs in genes","volume":"63","author":"Goddard","year":"2007","journal-title":"Hum Hered"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev.pa.36.040196.001223","article-title":"Molecular mechanisms of estrogen carcinogenesis","volume":"36","author":"Yager","year":"1996","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/jomb-2013-0039","article-title":"Introduction to molecular genetic diagnostics","volume":"33","author":"Novakovi\u0107","year":"2014","journal-title":"J Med Biochem"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"16681","DOI":"10.1371\/journal.pone.0016681","article-title":"Epistasis between COMT and MTHFR in maternal - fetal dyads increases risk for preeclampsia","volume":"6","author":"Hill","year":"2011","journal-title":"PLoS One"},{"key":"ref171","article-title":"R Core Team A language and environment for statistical computing R Foundation for Statistical Computing URL http : \/ \/ www - project org","author":"Vienna","year":"2014","journal-title":"Austria"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/(SICI)1096-8628(20000410)91:4<256::AID-AJMG3>3.0.CO;2-T","article-title":"Genetic effects on the liability of developing pre - eclampsia and gestational hypertension","volume":"91","author":"Salonen Ros","year":"2000","journal-title":"Am J Med Genet"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/molehr\/gar014","article-title":"A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort","volume":"17","author":"Roten","year":"2011","journal-title":"Mol Hum Reprod"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.arcmed.2012.03.002","article-title":"Association between Val Met functional polymorphism in the COMT gene and risk of preeclampsia in the Chinese population","volume":"158","author":"Liang","year":"2012","journal-title":"Arch Med Res"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/1471-0528.12629","article-title":"; WHO Multicountry Survey on Maternal and Newborn Health Research Network Pre - eclampsia , eclampsia and adverse maternal and perinatal outcomes : a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health","volume":"121","author":"Abalos","year":"2014","journal-title":"BJOG"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/OGX.0b013e3182331028","article-title":"A Critical Review of Early - Onset and Late - Onset Preeclampsia","volume":"66","author":"Raymond","year":"2011","journal-title":"Obstet Gynecol Surv"},{"key":"ref61","first-page":"357","article-title":"Pathogenesis and genetics of pre - eclampsia","author":"Roberts","year":"2001","journal-title":"Lancet"},{"key":"ref31","first-page":"377","article-title":"National , regional , and worldwide estimates of stillbirth rates in with trends since a systematic analysis","author":"Cousens","year":"2009","journal-title":"Lancet"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2174\/1389200023337586","article-title":"Catechol - - methyltransferase COMT ) - mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics : importance in pathophysiology and pathogenesis","volume":"3","author":"Zhu","year":"2002","journal-title":"Curr Drug Metab"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.mp.4001386","article-title":"Wein - shilboum RM Human catechol O methyltransferase genetic variation : gene resequencing and functional characterization of variant allozymes","volume":"9","author":"Shield","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/jmf.10.3.182.185-10","article-title":"TO Oxidant damage to DNA and pregnancy outcome Matern","volume":"10","author":"Scholl","year":"2001","journal-title":"Fetal Med"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1034\/j.1600-0897.2002.01076.x","article-title":"Preeclampsia : a multifactorial disease resulting from the interaction of the feto - maternal HLA genotype and HCMV infection","volume":"48","author":"Carreiras","year":"2002","journal-title":"Am J Reprod Immunol"},{"key":"ref111","first-page":"37","article-title":"The role of genetics in preeclampsia and potential pharmacogenomic interventions","volume":"5","author":"Williams","year":"2012","journal-title":"Pharmagenomics Pers Med"},{"key":"ref91","first-page":"453","article-title":"Deficiency in catechol - methyltransferase and - methoxyoestradiol is associated with pre - eclampsia","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Sham Genetic Power Calculator : design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1002\/1097-0142(19930515)71:10<3036::AID-CNCR2820711025>3.0.CO;2-P","article-title":"The etiology of breast cancer : characteristic alterations in hydroxyl radical - induced DNA base lesions during oncogenesis with potential for evaluating incidence risk","volume":"71","author":"Malins","year":"1993","journal-title":"Cancer"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ajmg.a.20512","article-title":"Recurrence risk of preeclampsia in twin and singleton pregnancies","volume":"126","author":"Trogstad","year":"2004","journal-title":"Am J Med Genet A"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1073\/pnas.93.6.2557","article-title":"Progression of human breast cancers to the metastatic state is linked to hydroxyl radical - induced DNA damage","volume":"93","author":"Malins","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/FPC.0b013e32833df033","article-title":"Do Genetic polymorphism of catechol - methyltransferase and cytochrome a in preeclampsia","volume":"20","author":"Lim","year":"2010","journal-title":"Pharmacogenet Genomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"101112","DOI":"10.1371\/journal.pone.0101112","article-title":"all members of the UN Inter - agency Group for Child Mortality Estimation and its Technical Advisory Group Child mortality estimation An overview of updates in estimation methods by the United Nations Inter - agency Group for child mortality estimation","volume":"9","author":"Alkema","year":"2013","journal-title":"PloS ONE"},{"key":"ref301","first-page":"287","article-title":"Maternal cigarette smoking , metabolic gene polymorphism , and infant birth weight","author":"Wang","year":"2002","journal-title":"JAMA"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/acta.0.1030282","article-title":"Concentrations of - metho - xyoestrogens in human serum measured by a heterologous immunoassay with an labelled ligand","volume":"103","author":"Berg","year":"1983","journal-title":"Acta Endocrinol"},{"key":"ref191","first-page":"950","article-title":"Preeclampsia and fetal growth","volume":"96","author":"Odegard","year":"2000","journal-title":"Obstet Gynecol"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1124\/dmd.110.033548","article-title":"- methylation of catechol estrogens by human placental catechol - o - methyltransferase : interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols","volume":"38","author":"Zhu","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death : A WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Global Health"},{"key":"ref321","first-page":"775","article-title":"Functional maternal catechol - methyl trans ferase polymorphism and fetal growth restriction Phar ma - cogenet","volume":"16","author":"Sata","year":"2006","journal-title":"Genomics"},{"key":"ref71","first-page":"376","article-title":"von Dadelszen Pre - eclampsia","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref81","first-page":"632732","article-title":"Re petto Pathogenesis of preeclampsia : the genetic component","author":"Valenzuela","year":"2012","journal-title":"J Pregnancy"}],"container-title":["Journal of Medical Biochemistry"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jomb\/35\/3\/article-p312.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2016\/1452-82581603312K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T20:34:25Z","timestamp":1588883665000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/article.aspx?artid=1452-82581603312K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":35,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/jomb-2016-0013","relation":{},"ISSN":["1452-8266"],"issn-type":[{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}