{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:39:08Z","timestamp":1782938348848,"version":"3.54.5"},"reference-count":20,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold>Bell\u2019s palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. The aim of this study was to investigate the possible role of oxidative stress in patients with BP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Thirty-two patients with BP and 30 healthy controls were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured by the Erel method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Serum TOS activities and OSI values were significantly higher in patients with BP compared with the control group (<jats:italic>P<\/jats:italic>&lt;0.003 for all comparisons), whereas there was no significant difference between the groups in terms of TAS levels (<jats:italic>P<\/jats:italic>&gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>The data suggest that oxidative stress is increased in BP. These results of high oxidative stress in patients with BP may be helpful to clarify the etiopathogenesis of BP and contribute to improvement in the management or prevention of the disease.<\/jats:p>","DOI":"10.1515\/jomb-2016-0033","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T10:01:35Z","timestamp":1482228095000},"page":"18-22","source":"Crossref","is-referenced-by-count":17,"title":["Oxidative Stress and Antioxidant Status in Patients with Bell\u2019s Palsy"],"prefix":"10.5937","volume":"36","author":[{"given":"Suat","family":"Terzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerrin \u00d6zergin","family":"Co\u015fkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir","family":"\u00d6zg\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"\u00c7eliker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcnir","family":"Demirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref91","first-page":"269","article-title":"Giuseppe Unbalanced oxidative status in idiopathic sudden sensorineural hearing loss","author":"Capaccio","year":"2012","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/fampra\/cmu058","article-title":"BP : a summary of current evidence and referral algorithm","volume":"31","author":"Glass","year":"2014","journal-title":"Fam Pract"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00129492-200501000-00020","article-title":"BP and Herpes simplex virus : fact or mystery","volume":"26","author":"Linder","year":"2005","journal-title":"Otol Neurotol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1046\/j.1468-3083.2003.00751.x","article-title":"Antioxidant activity , lipid peroxidation and skin diseases What s new","volume":"17","author":"Briganti","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/jomb-2015-0006","article-title":"Evaluation of systemic antioxidant level and oxidative stress in relation to lifestyle and disease progression in asthmatic patients","volume":"35","author":"Singh","year":"2016","journal-title":"J Med Biochem"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s10072-011-0857-0","article-title":"Serum prolidase activity and oxidative status in patients with diabetic neuropathy","volume":"33","author":"Uzar","year":"2012","journal-title":"Neurol Sci"},{"key":"ref11","first-page":"500","article-title":"BP : the spontaneous course of peripheral facial nerve palsies of different etiologies","author":"Peitersen","year":"2002","journal-title":"Acta Otolaryngol Suppl"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/000348947508400402","article-title":"Idiopathic facial paralysis pregnancy and the menstrual cycle","volume":"4","author":"Hilsinger","year":"1975","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation , more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1365-2265.2002.01638.x","article-title":"Oxidative stress and normal pregnancy","volume":"57","author":"Toescu","year":"2002","journal-title":"Clin Endocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.autrev.2012.05.008","article-title":"de BP and autoimmunity","volume":"12","author":"Greco","year":"2012","journal-title":"Autoimmun Rev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/1099-1654(200009\/10)10:5<285::AID-RMV269>3.0.CO;2-H","article-title":"Herpes simplex virus as a cause of BP","volume":"10","author":"McCormick","year":"1972","journal-title":"Rev Med Virol"},{"key":"ref111","first-page":"1089","article-title":"Evaluation of total antioxidant status , total oxidant status and oxidative stress index in patients with alopecia areata","volume":"7","author":"Motor","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7326\/0003-4819-124-1_Part_1-199601010-00005","article-title":"Bell palsy and herpes simplex virus : identification of viral DNA in endoneurial fluid and muscle","volume":"124","author":"Murakami","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0030-6665(20)31118-X","article-title":"Differential diagnosis of facial nerve palsy","volume":"24","author":"May","year":"1991","journal-title":"Otolaryngol Clin North Am"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1046\/j.1365-2362.1997.1390687.x","article-title":"Antioxidant status in patients with un complicated insulin - dependent and non - insulin - dependent diabetes mellitus","volume":"27","author":"Maxwell","year":"1997","journal-title":"Eur J Clin Invest"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/jnnp-2014-309563","article-title":"BP : aetiology , clinical features and multidisciplinary care","volume":"86","author":"Eviston","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.anl.2006.09.005","article-title":"Analysis of prognostic factors in BP and Ramsay Hunt syndrome","volume":"34","author":"Yeo","year":"2007","journal-title":"Auris Nasus Larynx"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1179\/1351000215Y.0000000002","article-title":"Determining oxidant and antioxidant status in patients with genital warts","volume":"20","author":"Cokluk","year":"2015","journal-title":"Redox Rep"}],"container-title":["Journal of Medical Biochemistry"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jomb\/36\/1\/article-p18.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2017\/1452-82581701018T.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T03:18:43Z","timestamp":1601263123000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/article.aspx?artid=1452-82581701018T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/jomb-2016-0033","relation":{},"ISSN":["1452-8266"],"issn-type":[{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]}}}