{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:15:54Z","timestamp":1777749354873,"version":"3.51.4"},"reference-count":34,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold>Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Significantly higher CVRS values (p&lt;0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p&lt;0.001, p&lt;0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLD indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC&gt;0.8) in identifying patients with increased cardiovascular risk (CVR).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.<\/jats:p>","DOI":"10.1515\/jomb-2017-0020","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T10:01:30Z","timestamp":1497088890000},"page":"259-269","source":"Crossref","is-referenced-by-count":25,"title":["Women with Polycystic Ovary Syndrome and Risk of Cardiovascular Disease"],"prefix":"10.5937","volume":"36","author":[{"given":"Iva Perovic","family":"Blagojevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Eror","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana","family":"Pelivanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Jelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Kotur-Stevuljevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Ignjatovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3964","reference":[{"key":"ref291","first-page":"340","article-title":"The Progective Effects of Estrogen on the Cardiovascular System The New","volume":"11","author":"Mendelsohn","year":"1999","journal-title":"Engl J Med"},{"key":"ref351","first-page":"57","article-title":"Liver enzymes and risk of diabetes and cardiovascular disease : Results of the Firenze Bagno a Ripoli study","volume":"92","author":"Monami","year":"2008","journal-title":"Metabolism"},{"key":"ref281","first-page":"82","article-title":"Female sex hormones and cardiovascular disease in women End Met","volume":"8","author":"Skafar","year":"1997","journal-title":"Clin"},{"key":"ref251","first-page":"40","article-title":"Dyslipidemia and oxidative stress in PCOS","volume":"63","author":"Macut","year":"2013","journal-title":"Front Horm Res"},{"key":"ref151","first-page":"101","article-title":"Defining Hyperandrogenism in Women With Polycystic Ovary Syndrome : A Challenging Perspective End Met","volume":"22","author":"Pasquali","year":"2016","journal-title":"Clin"},{"key":"ref271","first-page":"95","article-title":"Lipid levels in polycystic ovary syndrome : systematic review and meta analysis","volume":"9","author":"Wild","year":"2011","journal-title":"Fertil Steril"},{"key":"ref51","first-page":"78","article-title":"Cardiovascular disease risk in women with PCOS","volume":"6","author":"Dokras","year":"2013","journal-title":"Steroids"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/humrep\/deg330","article-title":"Elevated basal FSH in normal cycling women is associated with unfavourable lipid levels and increased cardiovascular risk","volume":"18","author":"Chu","year":"2003","journal-title":"Hum Repr"},{"key":"ref81","first-page":"121","article-title":"Lipid Accumulation Product is Related to Metabolic Syndrome in Women with Polycystic Ovary Syndrome End Diab","volume":"8","author":"Xiang","year":"2013","journal-title":"Exp Clin"},{"key":"ref21","first-page":"126","article-title":"Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization","volume":"32","author":"Birdsall","year":"1997","journal-title":"Ann Intern Med"},{"key":"ref241","first-page":"171","article-title":"The Polycystic Ovary Syndrome : an Endocrinological Perspective from the European Society of Endocrinology End","volume":"98","author":"Conway","year":"2014","journal-title":"Eur"},{"key":"ref321","first-page":"82","article-title":"Association of sex hormones with incident - year cardiovascular disease and mortality in women","volume":"30","author":"Schaffrath","year":"2015","journal-title":"Maturitas"},{"key":"ref231","first-page":"95","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome : a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society End Met","volume":"49","author":"Wild","year":"2010","journal-title":"Clin"},{"key":"ref201","first-page":"58","article-title":"Cardiovascular risk in women with polycystic ovarian syndrome","volume":"4","author":"Bickerton","year":"2005","journal-title":"J Clin Pathol"},{"key":"ref111","first-page":"68","article-title":"Index of central obesity A novel parameter","volume":"5","author":"Parikh","year":"2007","journal-title":"Med Hypotheses"},{"key":"ref101","first-page":"42","article-title":"Hepatic steatosis index : A simple screening tool reflecting non - alcoholic fatty liver disease","volume":"8","author":"Lee","year":"2010","journal-title":"Dig Liver Dis"},{"key":"ref191","first-page":"3696","article-title":"The Cardiovascular Risk of Young Women with Polycystic Ovary Syndrome : An Observational , Analytical , Prospective Case - Control Study End Met","volume":"89","author":"Orio","year":"2003","journal-title":"Clin"},{"key":"ref131","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/36.1.15","article-title":"Estimating low - density lipoprotein cholesterol by the Friede - wald equation is adequate for classifying patients on the basis of nationally recommended cutpoints","volume":"36","author":"Warnick","year":"1990","journal-title":"Clin Chem"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1210\/jc.2006-2725","article-title":"Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance","volume":"92","author":"Carmina","year":"2007","journal-title":"JCEM"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1093\/humrep\/dep072","article-title":"Lipid accumulation product index : a reliable marker of cardiovascular risk in polycystic ovary syndrome","volume":"24","author":"Wiltgen","year":"2009","journal-title":"Hum Repr"},{"key":"ref261","first-page":"155","article-title":"Oxidised low - density lipoprotein concentration early marker of an altered lipid metabolism in young women with PCOS End","volume":"6","author":"Macut","year":"2006","journal-title":"Eur"},{"key":"ref61","first-page":"65","article-title":"Non - alcoholic fatty liver disease and risk of cardiovascular disease","volume":"50","author":"Lonardo","year":"2015","journal-title":"Metabolism"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2003-0004","article-title":"Polycystic Ovary Syndrome and Cardiovascular Disease : A Premature Association","volume":"24","author":"Legro","year":"2003","journal-title":"End Rev"},{"key":"ref141","first-page":"165","article-title":"Risk scores predict atherosclerotic lesions in young people","volume":"90","author":"McMahan","year":"2005","journal-title":"Arch Intern Med"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/humrep\/16.3.556","article-title":"Prevalence of diabetes mellitus , hypertension and cardiac complaints in a follow - up study of a Dutch PCOS population","volume":"16","author":"Elting","year":"2001","journal-title":"Hum Reprod"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.15.9.1512","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis : a report from the Committee on Vascular Lesions of the Council on Arteriosclerosis , American Heart Association","volume":"15","author":"Stary","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF03347408","article-title":"Prevalence and metabolic characteristics of adrenal androgen excess in hyperandrogenic women with different phenotype","volume":"30","author":"Carmina","year":"2007","journal-title":"End Invest"},{"key":"ref01","first-page":"145","article-title":"DHEA DHEAS and PCOS","volume":"25","author":"Goodarzi","year":"2015","journal-title":"Ster Bioch"},{"key":"ref171","first-page":"292","article-title":"de Efficacy and safety of statin therapy in children with familial hypercholesterolemia : a randomized controlled trial","volume":"7","author":"Wiegman","year":"2004","journal-title":"JAMA"},{"key":"ref71","first-page":"47","article-title":"Non - alcoholic fatty liver disease in women with polycystic ovary syndrome","volume":"7","author":"Cerda","year":"2007","journal-title":"Hepatology"},{"key":"ref41","first-page":"282","article-title":"Are surrogate markers adequate to assess cardiovascular disease drugs","volume":"5","author":"Temple","year":"1999","journal-title":"JAMA"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome : the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"ref91","first-page":"182","article-title":"Relationship between aspartate aminotransferase - to - platelet ratio index and carotid intima - media thickness in obese adolescents with non - alcoholic fatty liver disease Ped End","volume":"5","author":"Sert","year":"2013","journal-title":"Clin Res"},{"key":"ref221","first-page":"49","article-title":"Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome","volume":"7","author":"Chen","year":"2007","journal-title":"Hypertension"}],"container-title":["Journal of Medical Biochemistry"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jomb\/36\/3\/article-p259.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2017\/1452-82581703259P.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T23:27:26Z","timestamp":1602286046000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/article.aspx?artid=1452-82581703259P"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,1]]},"references-count":34,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1515\/jomb-2017-0020","relation":{},"ISSN":["1452-8266"],"issn-type":[{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,1]]}}}