{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:52:03Z","timestamp":1790070723182,"version":"4.0.1"},"reference-count":23,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold>The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>Serum CysC levels were statistically higher in both COPD groups than the control group (p&lt;0.001 for both) although there was no statistically significant difference between COPD groups (p&gt;0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV<jats:sub>1<\/jats:sub>) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p&lt;0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909\u20130.994 95% CI: p&lt;0.001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold>Our results showed that CysC levels increased in both COPD groups. Increased CysC levels may be related with lung function decline and inflammation in COPD patients. In addition, CysC levels may be a potential indicator for the diagnosis of COPD.<\/jats:p>","DOI":"10.1515\/jomb-2017-0063","type":"journal-article","created":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T10:00:41Z","timestamp":1516960841000},"page":"434-440","source":"Crossref","is-referenced-by-count":22,"title":["Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions"],"prefix":"10.5937","volume":"37","author":[{"given":"Selda","family":"Telo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"Kulu\u00f6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Figen","family":"Deveci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"K\u0131rk\u0131l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6nsel","family":"\u00d6ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"Kaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref51","first-page":"413","article-title":"Significant elevation of plasma cathepsin and cystatin in patients with community - acquired pneumonia","volume":"5","author":"Lee","year":"2012","journal-title":"Clin Chim Acta"},{"key":"ref251","first-page":"186","article-title":"kai nen Recognition of cytoplasmic RNA results in cathepsin - dependent inflammasome activation and apoptosis in human macrophage","volume":"26","author":"Rintahaka","year":"2011","journal-title":"J Immunol"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s40520-013-0150-6","article-title":"Serum cystatin and indices of lung function in elderly Chinese men with chronic obstructive pulmonary disease","volume":"19","author":"Zhang","year":"2014","journal-title":"Aging Clin Exp Res"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1515\/jomb-2017-0011","article-title":"CRP as biomarkers in discrimination of communityacquired pneumonia and exacerbation of","volume":"20","author":"\u00c7olak","year":"2017","journal-title":"COPD J Med Biochem"},{"key":"ref01","first-page":"1","article-title":"TA IS Airway and systemic inflammation and decline in lung function in patients with","author":"Donaldson","year":"2005","journal-title":"COPD Chest"},{"key":"ref151","first-page":"41","article-title":"OH cathepsin production by alveolar macrophages from smokers and nonsmokers","volume":"16","author":"Warfel","year":"1991","journal-title":"Zucker Biol"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1053\/ajkd.2001.20628","article-title":"Serum cystatin concentration as a marker of renal dysfunction in the elderly","volume":"23","author":"Fliser","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"ref171","first-page":"625","article-title":"Serum as an Inflammatory Marker in - cerbated and Convalescent Patients mation","volume":"18","author":"Zhang","year":"2016","journal-title":"COPD"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1515\/jomb-2017-0012","article-title":"Evaluation of vitamin vitamin binding protein gene polymorphism with oxidant - antioxidant profiles in chronic obstructive pulmonary disease","author":"Azzawi","year":"2017","journal-title":"J Med Biochem"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1515\/CCLM.1999.064","article-title":"Serum cystatin as an endogenous marker of the renal function a","volume":"22","author":"Randers","year":"1999","journal-title":"review Clin Chem Lab Med"},{"key":"ref241","first-page":"585","article-title":"Cells mediators like receptors in","volume":"25","author":"Sarir","year":"2008","journal-title":"COPD Eur J Pharmacol"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4187\/respcare.04034","article-title":"Ran as a Predictor of In - Hospital Mortality After Exacerbation of","volume":"21","author":"Hu","year":"2016","journal-title":"COPD Respir Care"},{"key":"ref161","first-page":"274","article-title":"Serum cystatin levels correlate with endothelial dysfunction in patients with the metabolic syndrome","volume":"17","author":"Balta","year":"2013","journal-title":"J Intern Med"},{"key":"ref81","first-page":"106","article-title":"NR NA Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease","author":"Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"key":"ref101","article-title":"Pocket Guide to Diagnosis Management Prevention Guide for Care Professionals Report","volume":"11","year":"2017","journal-title":"COPD Health"},{"key":"ref41","first-page":"190","article-title":"Serum cystatin emphysema results from the National Examination Survey","author":"Rokadia","year":"2012","journal-title":"Health Nutrition Lung"},{"key":"ref11","first-page":"130","article-title":"DA Does Protease - Antiprotease Imbalance Explain Chronic Obstructive Pulmonary Disease","volume":"13","author":"Lomas","year":"2016","journal-title":"Ann Am Soc"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1053\/j.ajkd.2010.11.021","article-title":"and albuminuria as risk factors for development of CKD stage the multi - ethnic study of atherosclerosis","author":"Shastri","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"ref21","first-page":"39","author":"Newman","year":"2012","journal-title":"Ann Clin Biochem"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1183\/09031936.98.12051033","article-title":"proteinases and cystatin in bronchoalveolar lavage fluid from subjects with subclinical emphysema","volume":"14","author":"Takeyabu","year":"1998","journal-title":"Eur Respir J"},{"key":"ref141","first-page":"190","article-title":"Serum cystatin emphysema results from the National ation Survey","volume":"15","author":"Rokadia","year":"2012","journal-title":"Health Nutrition Lung"},{"key":"ref121","first-page":"141","article-title":"Identification of cystatin a cysteine proteinase inhibitor as a major secretory product of human alveolar macrophages in vitro","volume":"13","author":"Chapman HA","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"ref111","first-page":"5","article-title":"Standardized lung function testing European Com mu nity for Coal Official Statement of the Euro pean Respiratory","volume":"12","author":"Steel","year":"1993","journal-title":"Society Eur Respir J"}],"container-title":["Journal of Medical Biochemistry"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/jomb\/37\/4\/article-p434.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2018\/1452-82581802121M.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T07:09:35Z","timestamp":1660374575000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/article.aspx?artid=1452-82581804434T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,1]]},"references-count":23,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1515\/jomb-2017-0063","relation":{},"ISSN":["1452-8266"],"issn-type":[{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,1]]}}}