{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:08:59Z","timestamp":1761523739119},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"s2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> In this overview an update is given on the pathogenesis, classification and differential diagnosis of overgrowth syndromes. In addition, height prognosis and therapeutic modalities available for managing mainly constitutional tall stature are discussed. Constitutional tall stature comprises normal variants in which one or both parents are tall. Primary disorders may have a prenatal onset and may be of chromosomal or genetic origin. Secondary overgrowth syndromes are most often the result of hormonal disturbances. Height prediction plays a key role in the management of tall children. Prediction equation models have been developed based on the growth data of healthy tall children. There is general agreement that a favourable effect on reducing ultimate height is obtained using high doses of sex steroids (girls 100-300 \u03bcg ethinyl- oestradiol; boys testosterone (T) ester depot preparations 250-1000 mg\/month), the height reduction being greater when the treatment is started at a lower chronological and\/or bone age. An alternative is the induction of puberty with low doses of sex steroids (girls 5-50 \u03bcg ethinyloestradiol; boys T esters 25-50 mg\/m<jats:sup>2<\/jats:sup>\/3 wk). In addition orthopaedic procedures have been suggested, but there is limited experience. Although psychosocial factors constitute the main reason for treating tall stature, extensive psychological investigations before or during height limiting therapy are lacking. Moreover, there are no objective data indicating lifelong psychosocial damage resulting from being tall.<\/jats:p>","DOI":"10.1515\/jpem-2001-s210","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T10:02:52Z","timestamp":1477994572000},"page":"975-984","source":"Crossref","is-referenced-by-count":11,"title":["Current Concepts in Tall Stature and Overgrowth Syndromes"],"prefix":"10.1515","volume":"14","author":[{"given":"S.L.S.","family":"Drop","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Sophia Children\u2019s Hospital, Erasmus University, Molewaterplein 60, 3015 GJ Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Greggio","sequence":"additional","affiliation":[{"name":"Paediatric Clinic, Azienda Ospedaliera, Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cappa","sequence":"additional","affiliation":[{"name":"Department of Diabetology, Ospedale Bambin Ges\u00f9, Palidoro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Division of Paediatrics, Universit\u00e0 degli Studi di Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,10,11]]},"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/jpem.2001.14.issue-s2\/jpem-2001-s210\/jpem-2001-s210.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2001-s210\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2001-s210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T17:27:27Z","timestamp":1676050047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2001-s210\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,1]]},"references-count":0,"journal-issue":{"issue":"s2","published-online":{"date-parts":[[2016,10,11]]},"published-print":{"date-parts":[[2001,7,1]]}},"alternative-id":["10.1515\/jpem-2001-s210"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2001-s210","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,7,1]]}}}