{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:26:16Z","timestamp":1780413976153,"version":"3.54.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rett syndrome is an X-linked dominant disorder frequently caused by the mutations in the methyl-CpG-binding protein 2 gene (MECP2). Its prevalence in the population is 1\/15,000\u201320,000. Patients with Rett syndrome present apparently normal psychomotor developments during the first 6\u201318 months of life. Subsequently, they show a short period of developmental stagnation followed by a rapid regression in language and motor development. Precocious puberty is characterized by premature breast and pubic hair development, and advanced bone age development at 8 years of age. We present a case of Rett syndrome and precocious puberty in a 6-year-old girl. At the age of 6, the first signs of precocious puberty appeared (Tanner stage 3). Laboratory measurements were detected as follows: luteinizing hormone (LH), 0.2 mIU\/mL; follicle-stimulating hormone (FSH), 1.1 mIU\/mL; estradiol, 36 pg\/mL; bone age, 9 years. The response to luteinizing hormone releasing hormone (gonadotropin-releasing hormone stimulation test) was characteristic for true precocious puberty (LH, 32 mIU\/mL; FSH, 26 mIU\/mL). This is the first reported case of precocious puberty related to Rett syndrome.<\/jats:p>","DOI":"10.1515\/jpem-2012-0418","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T14:08:59Z","timestamp":1366034939000},"page":"937-939","source":"Crossref","is-referenced-by-count":14,"title":["Report of the first case of precocious puberty in Rett syndrome"],"prefix":"10.1515","volume":"26","author":[{"given":"Veysel Nijat","family":"Ba\u015f","sequence":"first","affiliation":[{"name":"Clinics of Pediatric Endocrinology, Dr. Sami Ulus Research and Training Hospital of Women\u2019s and Children\u2019s Health and Diseases, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semra","family":"\u00c7etinkaya","sequence":"additional","affiliation":[{"name":"Clinics of Pediatric Endocrinology, Dr. Sami Ulus Research and Training Hospital of Women\u2019s and Children\u2019s Health and Diseases, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahat Y\u0131lmaz","family":"A\u011flad\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Clinics of Pediatric Endocrinology, Dr. Sami Ulus Research and Training Hospital of Women\u2019s and Children\u2019s Health and Diseases, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Clinics of Pediatric Neurology, Dr. Sami Ulus Research and Training Hospital of Women\u2019s and Children\u2019s Health and Diseases, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u015fak","family":"G\u00fclp\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2013,4,2]]},"container-title":["jpem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2012-0418\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2012-0418\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T02:09:47Z","timestamp":1718417387000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2012-0418\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,2]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2013,4,2]]},"published-print":{"date-parts":[[2013,10,1]]}},"alternative-id":["10.1515\/jpem-2012-0418"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2012-0418","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,2]]}}}