{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:31:32Z","timestamp":1765827092338},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Data sources:<\/jats:bold> Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science<jats:sup>\u00ae<\/jats:sup>.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Study selection:<\/jats:bold> Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Outcome measure:<\/jats:bold> Resolution of gynecomastia.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.<\/jats:p>","DOI":"10.1515\/jpem-2013-0052","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T20:39:11Z","timestamp":1369946351000},"page":"803-807","source":"Crossref","is-referenced-by-count":41,"title":["Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review"],"prefix":"10.1515","volume":"26","author":[{"given":"Oren","family":"Lapid","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, University of Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan J.","family":"van Wingerden","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Center, University of Amsterdam, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Perlemuter","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Nutrition, CHU Henri-Mondor, Universit\u00e9 Paris Est, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,5,24]]},"container-title":["jpem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0052\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0052\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:15:51Z","timestamp":1653974151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0052\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2013,5,24]]},"published-print":{"date-parts":[[2013,10,1]]}},"alternative-id":["10.1515\/jpem-2013-0052"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2013-0052","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,24]]}}}