{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:04Z","timestamp":1761519064933},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background:<\/jats:bold> A typical peak timing in the glucagon stimulation test has been reported as an indication of growth hormone (GH) deficiency. Other stimulation tests have not been evaluated.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To evaluate the clinical usefulness of peak timing in the arginine stimulation test (AST) for growth hormone deficiency.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Retrospective review of 199 ASTs from one center. Outcomes included correlation of peak times with (a) frequency of deficient peak; (b) growth velocity standard deviation scores (GVSDSs); (c) other evidence of pituitary pathology; (d) results of confirmatory clonidine test; and (e) response to GH treatment.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The peak in 83\/109 (76.14%) sufficient tests occurred at typical times vs. 45\/72 (62.5%) deficient tests (p&lt;0.05). GVSDS on GH treatment was greater among patients with typical timing in the AST compared with atypical timing (2.67\u00b10.59 vs. 0.46\u00b11.17, p=0.021). No other variable correlated significantly with AST timing.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Timing of peak in the AST is not a clinically useful parameter.<\/jats:p>","DOI":"10.1515\/jpem-2013-0075","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T20:39:11Z","timestamp":1369946351000},"page":"813-817","source":"Crossref","is-referenced-by-count":6,"title":["The arginine stimulation test: timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency"],"prefix":"10.1515","volume":"26","author":[{"given":"David","family":"Gillis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadav","family":"Granat","sequence":"additional","affiliation":[{"name":"Hebrew University Hadassah School of Medicine, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Strich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2013,5,24]]},"container-title":["jpem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0075\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0075\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:15:13Z","timestamp":1653974113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0075\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,24]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2013,5,24]]},"published-print":{"date-parts":[[2013,10,1]]}},"alternative-id":["10.1515\/jpem-2013-0075"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2013-0075","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,24]]}}}