{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:11:49Z","timestamp":1759961509460},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Aim:<\/jats:bold> The purpose of this study was to search for the effects of adenotonsillectomy (A&amp;T) on height, weight, and body mass index (BMI), as well as changes in ghrelin, leptin, and insulin-like growth factor 1 (IGF-1) levels in children with adenotonsillar hypertrophy (ATH)-related sleep-disordered breathing (SDB).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> A study cohort of 39 children clinically diagnosed with ATH-related SDB was included in this study. Twenty-three healthy children were included as controls. Height and weight standard deviation scores (SDS) and ghrelin, leptin, and IGF-1 levels of the controls were determined once; in the study group, they were determined preoperatively and in the third month postoperatively. <\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Preoperative IGF-1 (ng\/mL) and ghrelin (pg\/mL) levels were significantly higher in the patients than in the controls (322.51\u00b1113.10 vs. 256.96\u00b1176.73, p&lt;0.05 and 106.08\u00b19.75 vs. 80.11\u00b128.50, p&lt;0.001, respectively). The preoperative height and weight SDS values of the patients were lower than those of the controls (\u20130.67\u00b11.36 vs. 0.13\u00b11.13, p&lt;0.05 and \u20130.38\u00b11.35 vs. \u20130.20\u00b11.29, respectively). The patients\u2019 postoperative height and weight SDS values were significantly higher than their preoperative values (\u20130.05\u00b11.08 vs. \u20130.67\u00b11.36, p&lt;0.0001 and 0.00\u00b11.28 vs. \u20130.38\u00b11.35, p&lt;0.0001, respectively). The mean postoperative IGF-1 levels also were significantly higher than preoperative levels (386.05\u00b1130.06 vs. 322.51\u00b1113.10, p&lt;0.05, respectively).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Plasma IGF-1 levels are lower in malnourished children, and plasma ghrelin levels are decreased after acute oral food intake and are increased in cachexia and fasting. Therefore, increased serum IGF-1 levels, height and weight SDS values, and decreased ghrelin levels detected postoperatively are useful parameters that help to monitor the development of children with adequate oral intakes.<\/jats:p>","DOI":"10.1515\/jpem-2013-0367","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T20:11:33Z","timestamp":1400789493000},"page":"885-890","source":"Crossref","is-referenced-by-count":9,"title":["The effect of adenotonsilectomy on ghrelin, leptin, IGF-1 levels and growth parameters in children with adenotonsillar hypertrophy"],"prefix":"10.1515","volume":"27","author":[{"given":"Nergis","family":"Salman","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Ankara Children\u2019s Hematology and Oncology Training and Research Hospital, 06110, Diskapi, Ankara\/Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulfer","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istemihan","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saffet","family":"Kilicaslan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Sanliurfa Training and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Demirel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Ankara Children\u2019s Hematology and Oncology Training and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namik","family":"Delibas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,5,22]]},"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0367\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T05:15:16Z","timestamp":1653974116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2013-0367\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2014,5,22]]},"published-print":{"date-parts":[[2014,9,20]]}},"alternative-id":["10.1515\/jpem-2013-0367"],"URL":"https:\/\/doi.org\/10.1515\/jpem-2013-0367","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}