{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T06:07:15Z","timestamp":1655878035206},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infantile anorexia nervosa (AN) is a specific eating disorder of prepubertal children. Poor data are available on growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in this disorder.<\/jats:p><jats:p>We report on a boy (4.5 years) with progressive growth impairment. At psychiatric assessment (DC: 0-3 R, AXIS I), he fulfilled all required criteria for diagnosis of infantile AN. Endocrine evaluation suggested impaired peripheral response to GH (high GH and low IGF-1 levels), likely related to energy deficiency.<\/jats:p><jats:p>Auxological evaluation was shown as raw data and SDS using Italian reference values. GH secretion was assessed by arginine provocative test; IGFI generation test was done administering recombinant GH (0.05 mg\/kg\/day for four days). Psychiatric assessment was performed according to the DC:0-3R protocol.<\/jats:p><jats:p>Impaired GH-IGF-1 axis may be involved in growth delay of children with infantile AN. A strict collaboration between endocrine pediatricians and child psychiatrists is advisable in the assessment of poor growing children without recognizable organic causes, showing normal\/high GH levels and low IGF-1 values.<\/jats:p>","DOI":"10.1515\/jpem-2013-0400","type":"journal-article","created":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T17:43:55Z","timestamp":1408124635000},"source":"Crossref","is-referenced-by-count":3,"title":["Growth impairment and growth hormone-IGF-1 axis in infantile anorexia nervosa"],"prefix":"10.1515","volume":"28","author":[{"given":"Silvia","family":"Ghione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Maestro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Dati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero I.","family":"Baroncelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Bertelloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref271","first-page":"220","article-title":"Determinants of resistance in malnutrition","author":"Fazeli","year":"2014","journal-title":"J Endocrinol"},{"key":"ref111","first-page":"275","article-title":"Increased physical activity and the growth hormone axis in adolescent males","volume":"14","author":"Eliakim","year":"1998","journal-title":"Am J Physiol"},{"key":"ref121","first-page":"220","article-title":"Determinants of resistance in malnutrition","author":"Fazeli","year":"2014","journal-title":"J Endocrinol"},{"key":"ref221","first-page":"198","article-title":"eating disorders national surveillance study","author":"Nicholls","year":"2011","journal-title":"Childhood British Psychiatry"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF03344156","article-title":"cross - 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