{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T18:43:25Z","timestamp":1758393805751},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test.<\/jats:p><jats:p>To determine the best predictive model for detecting puberty in girls.<\/jats:p><jats:p>Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n=20) or premature thelarche\/premature adrenarche (n=15).<\/jats:p><jats:p>Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed.<\/jats:p><jats:p>The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%.<\/jats:p><jats:p>The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.<\/jats:p>","DOI":"10.1515\/jpem-2014-0135","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T10:06:53Z","timestamp":1418724413000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls"],"prefix":"10.1515","volume":"0","author":[{"given":"Vivian L.","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bina","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref111","article-title":"Gonadotropin - releasing hormone testing in pediatrics In Ranke MB editor Diagnostics of endocrine function in children and adolescents Johann Ambrosius","author":"Roger","year":"1996"},{"key":"ref151","first-page":"893","article-title":"of a highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatization","author":"Fiers","year":"2012","journal-title":"Development J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref141","first-page":"123","article-title":"Group Consensus statement on the use of gonadotropin - releasing hormone analogs in children","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"ref81","first-page":"123","article-title":"AR PA Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls","author":"Houk","year":"2009","journal-title":"Pediatrics"},{"key":"ref231","first-page":"127","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","author":"Neely EK","year":"1995","journal-title":"J Pediatr"},{"key":"ref131","first-page":"3539","article-title":"Diagnostic value of fluorometric assays in the evaluation of precocious puberty","author":"Brito","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref221","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin - releasing hormone - stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1542\/peds.97.4.517","article-title":"single - sample subcutaneous gonadotropin - releasing hormone test for central precocious puberty","author":"Eckert","year":"1996","journal-title":"Pediatrics"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1093\/humrep\/deh519","article-title":"agonist stimulation of the pituitary - gonadal axis in children : age and sex differences in circulating inhibin activin","volume":"19","author":"Elsholz","year":"2004","journal-title":"Hum Reprod"},{"key":"ref241","first-page":"123","article-title":"AR PA Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls","author":"Houk","year":"2009","journal-title":"Pediatrics"},{"key":"ref261","first-page":"851","article-title":"Garibaldi The relationship between luteinizing hormone and estradiol secretion in female precocious puberty : evaluation by sensitive gonadotropin assays and the leuprolide stimulation test","author":"Aceto","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref181","first-page":"161","article-title":"Chi CH Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls : correlation between clinical diagnosis and time of peak luteinizing hormone level","author":"Durham","year":"2012","journal-title":"J Pediatr"},{"key":"ref211","first-page":"936","article-title":"Reexamination of the age limit for defining when puberty is precocious in girls in the United States : implications for evaluation and treatment Drug and Therapeutics and Executive Committees of the Pediatric","author":"Kaplowitz","year":"1999","journal-title":"Endocrine Society Pediatrics"},{"key":"ref01","first-page":"148","article-title":"PA Laboratory monitoring of children with precocious puberty Arch","author":"Lee","year":"1994","journal-title":"Med"},{"key":"ref11","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders : comparison with the gonadotropin - releasing hormone test","volume":"78","author":"Ibanez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref51","first-page":"936","article-title":"Reexamination of the age limit for defining when puberty is precocious in girls in the United States : implications for evaluation and treatment Drug and Therapeutics and Executive Committees of the Pediatric","author":"Kaplowitz","year":"1999","journal-title":"Endocrine Society Pediatrics"},{"key":"ref161","first-page":"148","article-title":"PA Laboratory monitoring of children with precocious puberty Arch","author":"Lee","year":"1994","journal-title":"Med"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2006-1569","article-title":"Assessment of basal and gonadotropin - releasing hormone - stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","author":"Resende","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1093\/humrep\/deh519","article-title":"agonist stimulation of the pituitary - gonadal axis in children : age and sex differences in circulating inhibin activin","volume":"19","author":"Elsholz","year":"2004","journal-title":"Hum Reprod"},{"key":"ref171","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders : comparison with the gonadotropin - releasing hormone test","volume":"78","author":"Ibanez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref291","first-page":"3539","article-title":"Diagnostic value of fluorometric assays in the evaluation of precocious puberty","author":"Brito","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref311","first-page":"893","article-title":"of a highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatization","author":"Fiers","year":"2012","journal-title":"Development J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref71","first-page":"127","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","author":"Neely EK","year":"1995","journal-title":"J Pediatr"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1542\/peds.97.4.517","article-title":"single - sample subcutaneous gonadotropin - releasing hormone test for central precocious puberty","author":"Eckert","year":"1996","journal-title":"Pediatrics"},{"key":"ref301","first-page":"123","article-title":"Group Consensus statement on the use of gonadotropin - releasing hormone analogs in children","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"ref121","first-page":"73","article-title":"Leuprolide stimulation testing for the evaluation of early female sexual maturation","author":"Sathasivam","year":"2010","journal-title":"Clin Endocrinol"},{"key":"ref101","first-page":"851","article-title":"Garibaldi The relationship between luteinizing hormone and estradiol secretion in female precocious puberty : evaluation by sensitive gonadotropin assays and the leuprolide stimulation test","author":"Aceto","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","first-page":"161","article-title":"Chi CH Pharmacodynamics of aqueous leuprolide acetate stimulation testing in girls : correlation between clinical diagnosis and time of peak luteinizing hormone level","author":"Durham","year":"2012","journal-title":"J Pediatr"},{"key":"ref271","article-title":"Gonadotropin - releasing hormone testing in pediatrics In Ranke MB editor Diagnostics of endocrine function in children and adolescents Johann Ambrosius","author":"Roger","year":"1996"},{"key":"ref281","first-page":"73","article-title":"Leuprolide stimulation testing for the evaluation of early female sexual maturation","author":"Sathasivam","year":"2010","journal-title":"Clin Endocrinol"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0135\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T12:46:10Z","timestamp":1650804370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0135\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,16]]},"references-count":30,"journal-issue":{"issue":"0"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2014-0135","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1,16]]}}}