{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:26:15Z","timestamp":1757312775944},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatoblastoma (HB), a primary liver tumor in childhood, is often accompanied by alpha-fetoprotein (AFP) secretion, and sometimes by \u03b2-human chorionic gonadotropin hormone (\u03b2-hCG) secretion, and this can cause peripheral precocious puberty (PPP). We describe a case of PPP associated with HB. Laboratory tests showed an increase in AFP, \u03b2-hCG and testosterone values, and suppression of follicle-stimulating hormone and luteinizing hormone levels. After chemotherapy and surgery, AFP, \u03b2-hCG and testosterone levels normalized and signs of virilization did not progress further. The child did not show evidence for tumor recurrence after 16 months of follow-up. New therapeutic approaches and early diagnosis may ensure a better prognosis of virilizing HB, than reported in the past. Assessment of PPP should always take into account the possibility of a tumoral source.<\/jats:p>","DOI":"10.1515\/jpem-2014-0167","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T07:57:46Z","timestamp":1410422266000},"source":"Crossref","is-referenced-by-count":8,"title":["Hepatoblastoma presenting as precocious puberty: a case report"],"prefix":"10.1515","volume":"28","author":[{"given":"Silvia","family":"Marino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Magro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"La Spina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Moscheo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Di Cataldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref381","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/pbc.24825","article-title":"causes of abnormal puberty","author":"Wendt","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1210\/jcem-35-6-857","article-title":"In vivo and in vitro production of human chorionic gonadotropin and alpha - 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