{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:12:05Z","timestamp":1761919925114},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a 9-year-old female who presented with new onset intractable seizure activity followed by a prolonged encephalopathic state. After ruling out common etiologies, Hashimoto\u2019s encephalopathy (HE) was considered, and antibody levels to thyroid peroxidase and thyroglobulin were both markedly elevated in her serum. She was euthyroid at the time of presentation. Upon treatment with high dose methylprednisolone, the patient demonstrated a significant improvement in her encephalopathy. The diagnosis of HE requires strong clinical suspicion with evidence of antithyroid antibodies, as well as an encephalopathy not explained by another etiology. While well documented in the adult literature, only a handful of pediatric cases have been described to date. Patients with HE have a nearly universal response to high dose glucocorticoids. HE should be considered in the differential diagnosis of any patient, adult or pediatric, who displays prolonged, unexplainable encephalopathy.<\/jats:p>","DOI":"10.1515\/jpem-2014-0205","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T08:21:48Z","timestamp":1421050908000},"source":"Crossref","is-referenced-by-count":3,"title":["Hashimoto\u2019s encephalopathy: a rare pediatric brain disease"],"prefix":"10.1515","volume":"28","author":[{"given":"Ryan M.","family":"Farrell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adetokunbo O.","family":"Omoruyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne E.","family":"Kingery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kupper A.","family":"Wintergerst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref241","first-page":"185","article-title":"High prevalence of serum autoantibodies against the amino terminal of alpha - enolase in encephalopathy","author":"Yoneda","year":"2007","journal-title":"J Neuroimmunol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jocn.2005.09.004","article-title":"protein levels and isoform patterns in the cerebrospinal fluid of Creutzfeldt - Jakob disease patients in the progressive and terminal stages","volume":"14","author":"Shiga","year":"2006","journal-title":"J Clin Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pediatrneurol.2009.09.011","article-title":"encephalopathy in a preschool 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