{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:30:08Z","timestamp":1787621408831,"version":"build-2736575974"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>: Diagnosis of isolated growth hormone deficiency (IGHD) can be challenging. As short stature is common in children, confirmed diagnosis is necessary prior to commencing treatment. Pituitary hypoplasia can be seen in children with IGHD. However, confirmatory studies are lacking.<\/jats:p><jats:p>To test the application of pituitary size as a marker for IGHD in a population-matched control.<\/jats:p><jats:p>Subjects with IGHD were enrolled. Patients had brain magnetic resonance imaging, and the height and width of the pituitary were measured. Pituitary volume was calculated as (height\u00d7width)<\/jats:p><jats:p>Sixty patients and 130 controls were enrolled. The median and age range for the patients and controls were 11 and 3\u201316 years and 9 and 3\u201317 years, respectively. Cases had a significantly lower dimensions compared to controls (p&lt;0.001).<\/jats:p><jats:p>Pituitary volume can be a useful marker to compliment the diagnosis of IGHD in selected patients when population-relevant normative control data are used.<\/jats:p>","DOI":"10.1515\/jpem-2014-0209","type":"journal-article","created":{"date-parts":[[2014,9,25]],"date-time":"2014-09-25T08:37:19Z","timestamp":1411634239000},"source":"Crossref","is-referenced-by-count":12,"title":["Pituitary gland size is a useful marker in diagnosing isolated growth hormone deficiency in short children"],"prefix":"10.1515","volume":"28","author":[{"given":"Asma","family":"Deeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Elhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbuBaker","family":"El Fatih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqan","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Nagelkerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref261","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2265.1996.tb02055.x","article-title":"Role of magnetic resonance imaging in the diagnosis and prognosis of growth hormone deficiency","volume":"45","author":"Bozzola","year":"1996","journal-title":"Clin Endocrinol"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/adc.41.219.454","article-title":"Standards from birth to maturity for height weight height velocity and weight velocity children","author":"Tanner","year":"1966","journal-title":"British Arch Dis Child"},{"key":"ref291","first-page":"85","article-title":"Consensus guidelines for the diagnosis and treatment of growth hormone deficiency in childhood and summary statement of the GH Research","year":"2000","journal-title":"Growth Hormone Research Society adolescence Society J Clin Endocrinol Metab"},{"key":"ref91","first-page":"261","article-title":"height on magnetic resonance imaging observation of age and sex related changes","author":"Ikram","year":"2008","journal-title":"Pituitary Med Assoc"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.beem.2010.06.007","article-title":"Wit Genetic evaluation of short stature","volume":"25","author":"Kiess","year":"2011","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/adc.41.219.454","article-title":"Standards from birth to maturity for height weight height velocity and weight velocity children","author":"Tanner","year":"1966","journal-title":"British Arch Dis Child"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00247-012-2349-7","article-title":"retrospective review of pituitary MRI findings in children on growth hormone therapy","author":"Tsai","year":"2012","journal-title":"Pediatr Radiol Pediatr Radiol"},{"key":"ref201","first-page":"9","article-title":"Morphological changes on MR imaging of the normal pituitary gland related to age and sex : main emphasis on pubescent females","author":"Kato","year":"2002","journal-title":"J Clin Neurosci"},{"key":"ref411","first-page":"36","article-title":"of normal pituitary gland on MR imaging age and sex differentiation Assist","volume":"14","author":"Suzuki","year":"1990","journal-title":"Comput"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.beem.2010.06.007","article-title":"Wit Genetic evaluation of short stature","volume":"25","author":"Kiess","year":"2011","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref191","first-page":"36","article-title":"of normal pituitary gland on MR imaging age and sex differentiation Assist","volume":"14","author":"Suzuki","year":"1990","journal-title":"Comput"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1136\/adc.65.11.1199","article-title":"function and morphological findings in patients with disorders of the hypothalamo - 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