{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T09:53:15Z","timestamp":1723024395956},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to investigate the effect of Gonadotropin-releasing hormone analogues (GnRHa) treatment on anterior pituitary hormones in female children with central precocious puberty (CPP).<\/jats:p><jats:p>There were 62 female children who had been diagnosed with CPP and received GnRHa (Leuprolide acetate, 3.75 mg intramuscular\/subcutaneous\/28 days) included in the study. All subjects were clinically evaluated prior to treatment and every 3 months during treatment with serum LH, FSH, ACTH, TSH, PRL as pituitary hormones, and the end hormones such as plasma E<\/jats:p><jats:p>: Prolactin levels were higher during GnRHa treatment compared to pre-treatment values although the increase was statistically significant only at month 3. In addition, while 2 (3.2%) of the patients had hyperprolactinemia before treatment, 11 (17.7%) patients developed hyperprolactinemia at different time points during treatment.<\/jats:p><jats:p>This study concluded that GnRHa treatment resulted in hyperprolactinemia and had no significant effect other pituitary hormones.<\/jats:p>","DOI":"10.1515\/jpem-2014-0222","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T11:22:57Z","timestamp":1432293777000},"source":"Crossref","is-referenced-by-count":2,"title":["Effects of GnRH analogue treatment on anterior pituitary hormones in children with central precocious puberty"],"prefix":"10.1515","volume":"28","author":[{"given":"Havva Nur","family":"Peltek Kendirci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahat Y\u0131lmaz","family":"A\u011flad\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u015fan","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veysel Nijat","family":"Ba\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"\u00c7etinkaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref301","first-page":"89","article-title":"GB Determinants of growth during gonadotropin - 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releasing hormone analog therapy for precocious puberty","author":"Weise","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref41","first-page":"1","article-title":"Turkish children s body weight length head circumference and body mass index reference values","volume":"51","author":"Neyzi","year":"2008"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2265.1996.tb02053.x","article-title":"Insulin - like growth factor IGF binding protein remain high after GnRH analogue therapy in girls with central precocious puberty","volume":"45","author":"Kanety","year":"1996","journal-title":"Clin Endocrinol"},{"key":"ref171","first-page":"1","article-title":"- releasing peptide and its homolog RFRP act in hypothalamus but not in anterior pituitary gland to stimulate stress hormone secretion","author":"Samson","year":"2003","journal-title":"Endocrine"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0015-0282(16)57841-8","article-title":"WE The effect of gonadotropin - 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