{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:54:44Z","timestamp":1785873284755,"version":"3.56.0"},"reference-count":52,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to examine the effect of chronic swallowed glucocorticoids on adrenal function during the treatment of eosinophilic esophagitis (EoE) in children.<\/jats:p><jats:p>Serum cortisol levels were obtained in children with EoE pre- and post-treatment with swallowed glucocorticoids. Exclusion criteria included those on any additional steroid therapy. Once diagnosed with EoE by esophageal biopsy, subjects were treated based on current standard of care with either swallowed fluticasone or budesonide. At the time of follow-up, esophagogastroduodenoscopy and blood sampling was repeated. Both pre- and post-treatment serum cortisol samples were collected fasting, between 07:00 and 10:00, and determined using a competitive binding method assay. The distribution of differences in cortisol levels between the pre- and post-treatment samples satisfied the assumption for normality and were subsequently analyzed using the paired t-test.<\/jats:p><jats:p>Pre- and post-treatment serum cortisol levels were examined in 14 children who met clinical and histological diagnostic criteria for EoE. Mean age was 10.1 years (range 2\u201317 years) with 71% male and 29% female subjects. Swallowed glucocorticoid treatment included fluticasone in 79% and budesonide in 21% of subjects. Mean dosage of fluticasone was 704 \u03bcg daily (range 220\u2013880 \u03bcg daily) and budesonide 0.8 mg daily (range 0.5\u20131 mg daily), along with a mean treatment length of 17 weeks (range 8\u201343 weeks). No significant difference in serum cortisol was found following treatment with swallowed fluticasone or budesonide (mean change 1.9 \u03bcg\/dL, p=0.75, SD of the change=21.2).<\/jats:p><jats:p>Swallowed glucocorticoid therapy does not appear to significantly affect the adrenal axis in children, and therefore, may represent a safe therapy for EoE.<\/jats:p>","DOI":"10.1515\/jpem-2014-0260","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:01:30Z","timestamp":1432908090000},"source":"Crossref","is-referenced-by-count":22,"title":["Swallowed glucocorticoid therapy for eosinophilic esophagitis in children does not suppress adrenal function"],"prefix":"10.1515","volume":"28","author":[{"given":"Katherine Q.","family":"Philla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve B.","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody N.","family":"Hefner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Reinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz G.","family":"Nazareno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref261","first-page":"128","article-title":"esophagitis updated consensus recommendations for children and adults quiz","volume":"21","author":"Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref421","first-page":"1","article-title":"Z\u00f6llner Hypothalamic - 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