{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:17:05Z","timestamp":1789593425154,"version":"build-2803163510"},"reference-count":94,"publisher":"Walter de Gruyter GmbH","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resistin is an adipocyte-derived signaling polypeptide described in adipose tissue, which acts as a metabolic link between inflammation and atherosclerosis. This study aimed to assess the relation between right ventricular (RV) function assessed by echocardiography and resistin levels in recently diagnosed type-1 diabetic children.<\/jats:p><jats:p>The study was conducted as a prospective cohort study and it included 30 children with type-1 diabetes mellitus as a patient group and 30 healthy children matched for age and sex as controls. It evaluated RV functions by tissue Doppler imaging, speckle tracking imaging, and real-time three-dimensional echocardiography (RT3DE), as well as assessing resistin serum level using enzyme-linked immunosorbent assay.<\/jats:p><jats:p>The left ventricle (LV) showed no significant difference between the two groups in E\/A ratio across the mitral valve, ejection fraction, and S wave mitral annulus. However, it showed significant decrease in the E\u2032\/A\u2032 wave of mitral annulus, impairment of LV myocardial performance index (MPI), and decrease in LV EF measured by RT3DE in diabetic patients compared to the control group. Significant differences in the mean value of tricuspid annular systolic excursion (TASE), pulmonary artery pressure, longitudinal systolic strain (RV LSS), MPI, and RV ejection fraction were observed between the studied groups. Yet, no significant differences in E\/A ratio and S value were observed between the two groups. Significant positive correlation of resistin level with age of studied group and significant negative correlation of resistin with both TASE and RV LSS values were also observed.<\/jats:p><jats:p>We confirmed the presence of subclinical RV systolic and diastolic dysfunction in type-1 diabetic children with positive correlation between resistin level and RV dysfunction among them.<\/jats:p>","DOI":"10.1515\/jpem-2014-0264","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T15:33:56Z","timestamp":1424273636000},"source":"Crossref","is-referenced-by-count":7,"title":["Resistin and right ventricular function in children with recently diagnosed type-1 diabetes mellitus: a case control study"],"prefix":"10.1515","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-9536","authenticated-orcid":false,"given":"Mohammed 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and function : the strong heart study","author":"Devereux","year":"2000","journal-title":"Circulation"},{"key":"ref631","first-page":"69","article-title":"Resistin is secreted from macrophages in atheromas and promotes","author":"Jung","year":"2006","journal-title":"atherosclerosis Cardiovasc Res"},{"key":"ref481","first-page":"1","article-title":"Increased resistin serum concentrations in patients with type diabetes mellitus","author":"Geyikli","year":"2013","journal-title":"Clin Res"},{"key":"ref381","first-page":"175","article-title":"EM Assessment of right ventricular function by myocardial performance index in diabetic patients","author":"Abdelaziz","year":"2011","journal-title":"Heart"},{"key":"ref421","first-page":"295","article-title":"induces pulmonary artery endothelial dysfunction by NADPH oxidase induction","author":"Lopez","year":"2008","journal-title":"Diabetes Am J Physiol Lung Cell Mol Physiol"},{"key":"ref601","first-page":"115","article-title":"Assessment of right 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angle","author":"Langeland","year":"2005","journal-title":"Circulation"},{"key":"ref411","first-page":"120","article-title":"Plasma markers of endothelial dysfunction in pulmonary hypertension","volume":"30","author":"Cella","year":"2001","journal-title":"Chest"},{"key":"ref711","first-page":"140","article-title":"Limitations inherent to the simplified Bernoulli equation explain the inaccuracy of Doppler echocardiographic estimates of pulmonary artery pressures in patients with pulmonary hypertension","author":"Giardini","year":"2011","journal-title":"Chest"},{"key":"ref881","first-page":"1","article-title":"GB Assessing right ventricular function : the role of echocardiography and complementary technologies i","author":"Bleeker","year":"2006","journal-title":"Heart"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1525-2167(02)00171-3","article-title":"Prognostic importance of the right ventricular function assessed by Doppler tissue 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phenotypes","author":"Thomopoulos","year":"2011","journal-title":"J Hum Hypertens"},{"key":"ref771","article-title":"Recommendations for chamber quantification : a report from the American Society of Echocardiography s Guidelines and Standards Committee and the Chamber Quantification Writing Group developed in conjunction with the European Association of a branch of the","volume":"18","author":"Lang","year":"2005","journal-title":"Echocardiography Cardiology Am Soc"},{"key":"ref911","first-page":"228","article-title":"NS NS HM Evaluation of right and left ventricular systolic and diastolic function in patients with type I using echocardiography and tissue Doppler imaging Suez Canal","volume":"11","author":"Elshahed","year":"2008","journal-title":"Med"},{"key":"ref131","first-page":"1","article-title":"of Echocardiography recommendations for quality echocardiography laboratory operations","volume":"24","author":"Picard","year":"2011","journal-title":"PS American Society Am 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Sci"},{"key":"ref591","first-page":"114","article-title":"Early diastolic impairment of diabetic heart : The significance of right ventricle","volume":"23","author":"Karamitsos","year":"2007","journal-title":"Int J Cardiol"},{"key":"ref101","first-page":"165","article-title":"MS Resistin functional roles and therapeutic considerations for cardiovascular disease","author":"Jamaluddin","year":"2012","journal-title":"Pharmacol"},{"key":"ref751","first-page":"838","article-title":"DO MD Doppler echocardiographic index for assessment of global right ventricular function","author":"Dujardin","year":"1996","journal-title":"Am Soc"},{"key":"ref261","first-page":"1","article-title":"Altered plasma adipokine levels and in vitro adipocyte differentiation in pediatric type diabetes","author":"Verrijn Stuart","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref1101","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.yjmcc.2008.05.006","article-title":"Role of resistin 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