{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T20:26:33Z","timestamp":1680380793565},"reference-count":60,"publisher":"Walter de Gruyter GmbH","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subjects with impaired glucose tolerance (IGT) are at risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease. The predictors of IGT in obese youth are not well described.<\/jats:p><jats:p>We studied 115 obese Thai children who underwent an oral glucose tolerance test (OGTT). Plasma glucose and insulin levels were calculated for assessment of \u03b2-cell function. Hemoglobin A1c (HbA1c), lipid profile, and clinical parameters were also used to determine predictors of IGT.<\/jats:p><jats:p>We found that three patients had T2DM and 30 subjects had IGT. IGT patients had significantly higher fasting glucose (FG), 1-h postload glucose, 2-h postload insulin, and lower whole-body insulin sensitivity indices than in normal glucose tolerance subjects whereas other indices were comparable. By ROC curve analyses, 1-h postload glucose was the best predictor of IGT, but FG or HbA1c represented a poor diagnostic tool for prediabetes screening. Subjects with 1-h OGTT glucose &gt;155 mg\/dL had significantly lower high-density lipoprotein levels, lower insulin sensitivity, and more insulin resistance than those with 1-h postload glucose of \u2264155 mg\/dL.<\/jats:p><jats:p>Abnormal glucose tolerance is highly prevalent in obese Thai youth. Several fasting indices and HbA1c fail to predict IGT. An 1-h OGTT glucose of &gt;155 mg\/dL appears to be more associated with adverse insulin dynamics and metabolic profile than 2-h postload glucose.<\/jats:p>","DOI":"10.1515\/jpem-2014-0273","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:01:30Z","timestamp":1432908090000},"source":"Crossref","is-referenced-by-count":1,"title":["Insulin dynamics and biochemical markers for predicting impaired glucose tolerance in obese Thai youth"],"prefix":"10.1515","volume":"28","author":[{"given":"Sirapassorn","family":"Tirabanchasak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukumarn","family":"Siripunthana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vichit","family":"Supornsilchai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suttipong","family":"Wacharasindhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taninee","family":"Sahakitrungruang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref531","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/MCG.0000000000000116","article-title":"Organisation global guidelines : nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","author":"LaBrecque","year":"2014","journal-title":"World Gastroenterology J Clin Gastroenterol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"920","DOI":"10.2337\/diacare.22.6.920","article-title":"Impaired glucose tolerance is a risk factor for cardiovascular disease but not impaired fasting glucose The Funagata Diabetes Study","volume":"22","author":"Tominaga","year":"1999","journal-title":"Diabetes Care"},{"key":"ref281","first-page":"124","article-title":"PC for type diabetes in obese youth","author":"Shah","year":"2009","journal-title":"Screening Pediatrics"},{"key":"ref401","first-page":"1","article-title":"Identifying adults at high risk for diabetes and cardiovascular disease using hemoglobin National Nutrition Examination Survey","volume":"40","author":"Ackermann","year":"2006","journal-title":"Health Am J Prev Med"},{"key":"ref571","doi-asserted-by":"crossref","DOI":"10.1515\/jpem-2012-0200","article-title":"Absence of diabetes mellitus type in obese children and adolescents in the north of","volume":"26","author":"Aguayo","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref361","first-page":"242","article-title":"Prevalence of overweight and obesity in Thai population : results of the National Thai Food Consumption Survey Eat Weight","volume":"16","author":"Jitnarin","year":"2011"},{"key":"ref81","first-page":"1","article-title":"level and future risk of diabetes a systematic","author":"Zhang","year":"2010","journal-title":"review Diabetes Care"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"AS Homeostasis model assessment : insulin resistance and beta - 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