{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T20:14:00Z","timestamp":1751487240177},"reference-count":42,"publisher":"Walter de Gruyter GmbH","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The obesity paradox refers to a category of subjects who may be less prone to develop co-morbidities, such as type 2 diabetes. Cardiorespiratory fitness (CRF) has been identified as one of the key factors. We aimed at exploring the difference in insulin metabolism between fit and unfit obese adolescents.<\/jats:p><jats:p>We recruited 22 obese adolescents and assessed CRF during an incremental treadmill test. According to a cut-off at 80% of predicted maximal oxygen consumption (VO<\/jats:p><jats:p>Compared to adolescents with normal CRF, the ones with low CRF had higher insulin resistance indices (p=0.023) and insulin secretion response (p=0.010), independently of the body mass index z-score.<\/jats:p><jats:p>Interventions in obese adolescents should focus on the maintenance or improvement of CRF to at least 80% of predicted VO<\/jats:p>","DOI":"10.1515\/jpem-2014-0321","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T17:01:34Z","timestamp":1413824494000},"source":"Crossref","is-referenced-by-count":3,"title":["Insulin secretion response during oral glucose tolerance test is related to low cardiorespiratory fitness in obese adolescents"],"prefix":"10.1515","volume":"28","author":[{"given":"Albane B.R.","family":"Maggio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie Wacker","family":"Bou Puigdefabregas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie M.","family":"Schwitzgebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chamay-Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Beghetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie J.","family":"Farpour-Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref131","first-page":"49","article-title":"Distribution of fasting plasma insulin free fatty acids and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents","author":"Allard","year":"2003","journal-title":"Clin Chem"},{"key":"ref431","first-page":"209","article-title":"Cardiopulmonary exercise testing In editor Manual of pulmonary function testing th ed St MO","author":"Ruppel","year":"2008"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1080\/02640414.2011.553965","article-title":"paradoxes","volume":"29","author":"McAuley","year":"2011","journal-title":"Obesity Sports Sci"},{"key":"ref501","first-page":"19","article-title":"indicators and risk factors of cardiovascular diseases during childhood and adolescence In editors Children and exercise XII Human Kinetics","author":"Bell","year":"1986","journal-title":"Health IL"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2337\/diacare.28.4.895","article-title":"Cardiorespiratory fitness attenuates metabolic risk independent of abdominal subcutaneous and visceral fat in men","volume":"28","author":"Lee","year":"2005","journal-title":"Diabetes Care"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/eurheartj\/ehs174","article-title":"The intriguing metabolically healthy but obese phenotype : cardiovascular prognosis and role of fitness","author":"Ortega","year":"2013","journal-title":"Eur Heart J"},{"key":"ref101","first-page":"312","article-title":"WHO WHO Standards length height for age weight for age weight for length weight for height and body mass index for age methods development WHO","author":"Child","year":"2006","journal-title":"Growth"},{"key":"ref31","first-page":"350","article-title":"the metabolic syndrome in children and adolescents","author":"Weiss","year":"2004","journal-title":"Obesity Engl J Med"},{"key":"ref41","first-page":"277","article-title":"Schwimmer Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease","author":"Pardee","year":"2008","journal-title":"Circulation"},{"key":"ref311","first-page":"277","article-title":"Schwimmer Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease","author":"Pardee","year":"2008","journal-title":"Circulation"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1515\/jpem-2012-0157","article-title":"Improved metabolic and cardiorespiratory fitness during a recreational training program in obese children","volume":"26","author":"Calcaterra","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev.me.44.020193.001005","article-title":"Role of insulin resistance in human disease syndrome an expanded definition","volume":"31","author":"Reaven","year":"1993","journal-title":"Annu Rev Med"},{"key":"ref381","first-page":"686","article-title":"Kamel EG Measurement of abdominal fat by magnetic resonance imaging dual ray absorptiometry and anthropometry in non - 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