{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:56:15Z","timestamp":1648803375216},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital adrenal hyperplasia (CAH) in children varies in presentation and progression with several challenges in optimal management. Effective treatment is to achieve normal growth and development while avoiding adrenal crisis and hyperandrogenisation.<\/jats:p><jats:p>Our aim was to ascertain the current practice in the UK on CAH management in children in comparison with the recommendations made by the Endocrine Society.<\/jats:p><jats:p>An online survey was emailed to the British Society of Paediatric Endocrinology (BSPED) members requesting a response from each centre regarding CAH management.<\/jats:p><jats:p>The survey was completed by 35 out of 92 centres (38% response rate). Tertiary centres constituted 22\/35, while 8\/35 were district general hospitals providing tertiary services. Treatment varied among centres with 25\/35 using 10\u201315 mg\/m<\/jats:p><jats:p>Our survey highlights the diversity in managing children with CAH in the UK as compared with the recommendations of the Endocrine Society. It also demonstrates inconsistent involvement of essential specialist services, which are essential for optimal management of this condition.<\/jats:p>","DOI":"10.1515\/jpem-2014-0362","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T08:57:51Z","timestamp":1436777871000},"source":"Crossref","is-referenced-by-count":1,"title":["Congenital adrenal hyperplasia in children \u2013 a survey on the current practice in the UK"],"prefix":"10.1515","volume":"28","author":[{"given":"Usha","family":"Niranjan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref61","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/jcem.86.1.7275","article-title":"suspension and hydrocortisone tablets are not bioequivalent in the treatment of children with congenital adrenal hyperplasia","author":"Merke","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref211","first-page":"266","article-title":"PC Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","author":"Charmandari","year":"2002","journal-title":"Arch Dis Child"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/jcem.86.1.7275","article-title":"suspension and hydrocortisone tablets are not bioequivalent in the treatment of children with congenital adrenal hyperplasia","author":"Merke","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"ref81","first-page":"193","article-title":"PC Management of the child with congenital adrenal hyperplasia Best Available at http www ncbi nlm nih gov pubmed","volume":"23","author":"Hindmarsh","year":"2009","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref161","first-page":"5680","article-title":"genotype adult height and pubertal development in patients treated for - hydroxylase deficiency Available at http www ncbi nlm nih gov pubmed","volume":"21","author":"Balsamo","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref131","first-page":"166","article-title":"Congenital adrenal hyperplasia an update in children Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","volume":"18","author":"Trapp","year":"2011","journal-title":"Curr Endocrinol Diabetes"},{"key":"ref01","first-page":"95","article-title":"Congenital adrenal hyperplasia due to steroid hydroxylase deficiency an clinical practice guideline","volume":"21","author":"Speiser","year":"2010","journal-title":"Endocrine Society J Clin Endocrinol"},{"key":"ref171","first-page":"3882","article-title":"Hydrocortisone dosing during puberty in patients with classical congenital adrenal hyperplasia : an evidence - based recommendation Available at http www ncbi nlm nih gov pubmed","author":"Bonfig","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref201","first-page":"193","article-title":"PC Management of the child with congenital adrenal hyperplasia Best Available at http www ncbi nlm nih gov pubmed","volume":"23","author":"Hindmarsh","year":"2009","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref111","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1651-2227.1999.tb14367.x","article-title":"related quality of life in intersexuality Available at http com","author":"Meyer","year":"1999","journal-title":"Health Acta Paediatr"},{"key":"ref191","first-page":"4707","article-title":"Control of childhood congenital adrenal hyperplasia and sleep activity and quality with morning or evening glucocorticoid therapy Available at : http www ncbi nlm nih gov pubmed","author":"German","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref121","first-page":"95","article-title":"Congenital adrenal hyperplasia due to steroid hydroxylase deficiency an clinical practice guideline","volume":"21","author":"Speiser","year":"2010","journal-title":"Endocrine Society J Clin Endocrinol"},{"key":"ref31","article-title":"HP Reduced final height outcome in congenital adrenal hyperplasia under prednisone treatment : deceleration of growth velocity during puberty Available at : http www ncbi nlm nih gov pubmed","author":"Bonfig","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref51","first-page":"3882","article-title":"Hydrocortisone dosing during puberty in patients with classical congenital adrenal hyperplasia : an evidence - based recommendation Available at http www ncbi nlm nih gov pubmed","author":"Bonfig","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","first-page":"77","article-title":"CM Recommendations for treatment of nonclassic congenital adrenal hyperplasia an update Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","author":"Trapp","year":"2012","journal-title":"Steroids"},{"key":"ref41","first-page":"5680","article-title":"genotype adult height and pubertal development in patients treated for - hydroxylase deficiency Available at http www ncbi nlm nih gov pubmed","volume":"21","author":"Balsamo","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref151","article-title":"HP Reduced final height outcome in congenital adrenal hyperplasia under prednisone treatment : deceleration of growth velocity during puberty Available at : http www ncbi nlm nih gov pubmed","author":"Bonfig","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref141","first-page":"77","article-title":"CM Recommendations for treatment of nonclassic congenital adrenal hyperplasia an update Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","author":"Trapp","year":"2012","journal-title":"Steroids"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1651-2227.1999.tb14367.x","article-title":"related quality of life in intersexuality Available at http com","author":"Meyer","year":"1999","journal-title":"Health Acta Paediatr"},{"key":"ref71","first-page":"4707","article-title":"Control of childhood congenital adrenal hyperplasia and sleep activity and quality with morning or evening glucocorticoid therapy Available at : http www ncbi nlm nih gov pubmed","author":"German","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","first-page":"166","article-title":"Congenital adrenal hyperplasia an update in children Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","volume":"18","author":"Trapp","year":"2011","journal-title":"Curr Endocrinol Diabetes"},{"key":"ref91","first-page":"266","article-title":"PC Why is management of patients with classical congenital adrenal hyperplasia more difficult at puberty Available at http www pubmedcentral nih gov articlerender fcgi artid tool pmcentrez rendertype abstract","author":"Charmandari","year":"2002","journal-title":"Arch Dis Child"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0362\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T01:38:12Z","timestamp":1619055492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0362\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":22,"journal-issue":{"issue":"7-8"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2014-0362","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}