{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:25:18Z","timestamp":1761765918645},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study, it was aimed to investigate the concomitance of additional cardiac problems, mainly mitral valve prolapse, in adolescents and pediatric patients with Hashimoto\u2019s thyroiditis, by screening autoimmune markers.<\/jats:p><jats:p>Fifty-seven euthyroid patients, who applied to the Pediatric Endocrinology clinic at our institution with marked symptoms of hypothyroidism at the time of diagnosis, and were diagnosed and treated for Hashimoto\u2019s thyroiditis, were included in the present study. All patients were evaluated by performing non-organ specific autoantibodies which could be tested at our institution, thyroid ultrasonography, two-dimensional echocardiography, and 24-h holter monitorization.<\/jats:p><jats:p>Of the 57 cases with Hashimoto\u2019s thyroiditis, 48 (84.2%) were female, and nine (15.8%) were male. In the echocardiographic evaluation, mitral valve problems were detected in 10 (17.5%) of all cases; mitral valve prolapse was diagnosed in eight (seven females and one male) cases, and mitral insufficiency was diagnosed in two female cases. First-degree atrioventricular block was observed in only two patients during 24-h holter monitorization. Different non-organ specific autoantibody positivity was distributed as antinuclear antibody in 15 (26.3%) cases, anticardiolipin IgG in two cases, anticardiolipin IgM in three cases, tissue transglutaminase IgA in one, glutamic acid decarboxylase in one, anti-insulin antibody in four cases, antiphospholipid IgG in one, and antiphospholipid IgM in one case.<\/jats:p><jats:p>It should be underlined that patients with Hashimoto\u2019s thyroiditis should to be followed up closely for mitral valve prolapse and accompanying autoimmune diseases.<\/jats:p>","DOI":"10.1515\/jpem-2014-0373","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:01:30Z","timestamp":1432908090000},"source":"Crossref","is-referenced-by-count":5,"title":["Investigation of autoimmune diseases accompanying Hashimoto\u2019s thyroiditis in children and adolescents and evaluation of cardiac signs"],"prefix":"10.1515","volume":"28","author":[{"given":"Veysel Nijat","family":"Ba\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebahat","family":"Y\u0131lmaz Agladioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senem","family":"\u00d6zg\u00fcr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selmin","family":"Karademir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref121","first-page":"1","article-title":"valve prolapse etiology clinical presentation and neuroendocrine function","author":"Boudoulas","year":"1992","journal-title":"J Heart Valve Dis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/0961203308098598","article-title":"Mitral valve prolapse in young healthy individuals An early index of autoimmunity","volume":"18","author":"Evangelopoulos","year":"2009","journal-title":"Lupus"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/thy.1999.9.973","article-title":"valve prolapse in autoimmune thyroid disease : an index of systemic autoimmunity","author":"Evangelopoulou","year":"1999","journal-title":"Thyroid"},{"key":"ref331","first-page":"1","article-title":"valve prolapse etiology clinical presentation and neuroendocrine function","author":"Boudoulas","year":"1992","journal-title":"J Heart Valve Dis"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF02114404","article-title":"specific and multisystemic autoimmune disease : part of a spectrum which may coexist in the same patient","author":"Gordon","year":"1990","journal-title":"Organ Clin Rheumatol"},{"key":"ref411","first-page":"209","article-title":"Prevalence follow - 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