{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:51:54Z","timestamp":1772938314658,"version":"3.50.1"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"11-12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    Little has been published on treatment of precocious puberty in girls with Williams-Beuren syndrome (WBS), a condition occurring frequently in this group. We analyzed our own data on growth\/age at menarche of now adult female patients with WBS being diagnosed with central precocious puberty or early puberty. Data of patients treated with gonadotropin-releasing hormone (GnRH) analog (n=13) were compared with those not treated (control group, n=11).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients:<\/jats:bold>\n                    Longitudinal data on the somatic development of 24 now adult female patients were analyzed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Medium final height was 157.2\u00b16.5 cm compared to 151.4\u00b15.6 cm in the control group. No significant difference could be found in the discrepancy of genetic target height and final height. Prepubertally girls were normal weight in both groups; in adulthood the majority of patients were overweight\/obese. Menarche commenced 11 months after cessation of therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    As already known from other studies, hormonal suppression via GnRH analog was well tolerated.\n                  <\/jats:p>","DOI":"10.1515\/jpem-2014-0393","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T13:02:10Z","timestamp":1437483730000},"page":"1363-1367","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of central precocious puberty and early puberty with GnRH analog in girls with Williams-Beuren syndrome"],"prefix":"10.1515","volume":"28","author":[{"given":"Sarah","family":"Spielmann","sequence":"first","affiliation":[{"name":"MVZ Pro Cura GmbH, M\u00f6llner Landstr. 29, 22111 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl Joachim","family":"Partsch","sequence":"additional","affiliation":[{"name":"Endokrinologikum Hamburg, Lornsenstr. 4-6, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Gosch","sequence":"additional","affiliation":[{"name":"Hochschule f\u00fcr angewandte Wissenschaften M\u00fcnchen, Am Stadtpark 20, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Pankau","sequence":"additional","affiliation":[{"name":"Ostseeklinik Boltenhagen, Ostseeallee 108, 23946 Ostseebad Boltenhagen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,7,18]]},"reference":[{"key":"2026030708551755439_j_jpem-2014-0393_ref_001_w2aab3b7c35b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Pober BR. 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