{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:30:30Z","timestamp":1770957030105,"version":"3.50.1"},"reference-count":70,"publisher":"Walter de Gruyter GmbH","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate auxology and metabolic disturbances in children with craniopharyngioma, and to present observational results of treatment of metabolic sequels with metformin and micronized fenofibrate.<\/jats:p><jats:p>The studied group comprised 22 children [median age at diagnosis 10.5 (0.17\u201316.75) years; median follow-up 5.1 years]. Assessment included height standard deviations (SDS), body mass index (BMI) SDS, concentrations of lipids, glucose and insulin (fasting or oral glucose tolerance test) and homeostatic model assessment of insulin resistance (HOMA-IR) index. Ten adolescents with hyperinsulinemia and dyslipidemia received therapy with metformin (500\u20131500 mg\/daily) and micronized fenofibrate (160 mg\/daily).<\/jats:p><jats:p>At diagnosis, median hSDS was \u20131.66 (range: \u20134.08; +0.1). Nine (40.9%) children were growth hormone-treated. There was gradual increase of BMI SDS, 18 (81.8%) patients being overweight at the final assessment. Dyslipidaemia was found in 19 patients (86.4%), hyperinsulinaemia in 11 patients (50%) and elevated HOMA-IR in 15 patients (68.2%). Decrease of triglycerides [median 263.5 (171\u2013362) mg\/dL vs. 154 (102\u2013183) mg\/dL] and HOMA-IR [8.64 (5.08\u201312.65) vs. 4.68 (0.7\u20137.9)] was significant in the group treated with metformin and fenofibrate for 6 months.<\/jats:p><jats:p>Significant auxologic changes and metabolic abnormalities were found in children treated for craniopharyngioma. The use of metformin and fenofibrate seemed to attenuate these disturbances in a short-term observation.<\/jats:p>","DOI":"10.1515\/jpem-2014-0425","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T17:04:35Z","timestamp":1419354275000},"source":"Crossref","is-referenced-by-count":9,"title":["Carbohydrate-lipid profile and use of metformin with micronized fenofibrate in reducing metabolic consequences of craniopharyngioma treatment in children: single institution experience"],"prefix":"10.1515","volume":"28","author":[{"given":"Maria Aleksandra","family":"Kalina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Wilczek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kalina-Faska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza","family":"Ska\u0142a-Zamorowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Mandera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Ma\u0142ecka Tendera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref41","first-page":"44","article-title":"Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents","author":"Gungor","year":"2004","journal-title":"J Pediatr"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1203\/pdr.0b013e3180332cd6","article-title":"Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma","author":"Roth","year":"2007","journal-title":"Pediatr Res"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1210\/jc.2003-030552","article-title":"defect in epinephrine production in children with craniopharyngioma functional or organic origin","author":"Coutant","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5414\/CPP42212","article-title":"Effects of micronized fenofibrate on insulin resistance in patients with metabolic syndrome","author":"Wysocki","year":"2004","journal-title":"Int J Clin Pharmacol Ther"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/pbc.24794","article-title":"CD phase II trial of a multiagent oral antiangiogenic metrnomic regimen in children with recurrent or progressive cancer","author":"Robinson","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1210\/jc.2007-0826","article-title":"Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes","author":"Danielsson","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref291","article-title":"ME Stimulant use and its impact on growth in children receiving growth hormone therapy : an analysis of the KIGS International Growth database","volume":"31","author":"Miller","year":"2014","journal-title":"Horm Res"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00381-009-0931-6","article-title":"Practical approach to childhood craniopharyngioma : a role of an endocrinologist and a general paediatrician","volume":"25","author":"Kalina","year":"2009","journal-title":"Child Nerv Syst"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00381-009-0931-6","article-title":"Practical approach to childhood craniopharyngioma : a role of an endocrinologist and a general paediatrician","volume":"25","author":"Kalina","year":"2009","journal-title":"Child Nerv Syst"},{"key":"ref151","first-page":"220","article-title":"Outcome of craniopharyngioma in children : long - 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operative hypothalamic lesions and obesity in childhood craniopharyngioma : results of the multinational prospective trial KRANIOPHARYNGEOM after - year follow - up","author":"M\u00fcller","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"ref441","first-page":"128","article-title":"Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents National and Institute Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents : summary","author":"Suppl","year":"2011","journal-title":"Heart Lung Blood Pediatrics"},{"key":"ref651","first-page":"156","article-title":"The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma","author":"Mason","year":"2002","journal-title":"Arch Med"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"417949","DOI":"10.1155\/2011\/417949","article-title":"Hypothalamic obesity following craniopharyngioma surgery : results of a pilot trial of combined diazoxide and metformin therapy","author":"Hamilton","year":"2011","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref161","first-page":"5227","article-title":"Harz M\u00fcller Waldeck Pudel in patients with craniopharyngioma : assessment of food intake and movement counts indicating physical activity","volume":"31","author":"Roth","year":"2003","journal-title":"Obesity J Clin Endocrinol Metab"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2337\/diacare.27.6.1487","article-title":"DR Use abuse of modelling","volume":"27","author":"Wallace","year":"2004","journal-title":"Diabetes Care"},{"key":"ref81","first-page":"89","article-title":"Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma","author":"M\u00fcller","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref531","first-page":"5227","article-title":"Harz M\u00fcller Waldeck Pudel in patients with craniopharyngioma : assessment of food intake and movement counts indicating physical activity","volume":"31","author":"Roth","year":"2003","journal-title":"Obesity J Clin Endocrinol Metab"},{"key":"ref431","first-page":"359","article-title":"Metabolic syndrome in obese Turkish children and adolescents : comparison of two diagnostic models","author":"Cizmecioglu","year":"2008","journal-title":"J Pediatr"},{"key":"ref241","first-page":"170","article-title":"Sahakitrungruang metabolic syndrome and insulin dynamics in children after craniopharyngioma surgery","author":"Klomchan","year":"2011","journal-title":"Obesity Eur J Pediatr"},{"key":"ref71","first-page":"128","article-title":"Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents National and Institute Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents : summary","author":"Suppl","year":"2011","journal-title":"Heart Lung Blood Pediatrics"},{"key":"ref471","first-page":"53","article-title":"Hormopnal factors influencing weight and growth pattern in craniopharyngioma","author":"Pinto","year":"2000","journal-title":"Horm Res"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1210\/jc.2002-030003","article-title":"Octreotide therapy of pediatric hypothalamic obesity : a double - 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