{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:21:32Z","timestamp":1756992092072},"reference-count":68,"publisher":"Walter de Gruyter GmbH","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to validate basal, post-gonadotropin-releasing hormone analogue (post-GnRHa) and first-voided urinary LH (ULH) as alternatives to an LHRH stimulation test in monitoring treatment efficacy in central precocious puberty (CPP).<\/jats:p><jats:p>Seventeen girls with CPP were followed over 22.5\u00b19.1 months during GnRHa (triptorelin) treatment. ULH and post-GnRHa LH levels were obtained every 4 months before and 24 h after GnRHa administration, respectively, along with clinical and bone age (BA) evaluation. LHRH stimulation tests were performed annually.<\/jats:p><jats:p>A total of 36 LHRH stimulation tests demonstrated adequate suppression with a peak LH of 0.57\u00b10.33 IU\/L. The corresponding basal LH was 0.27\u00b10.16 IU\/L. Ninety post-GnRHa LH measurements were similar to LHRH-stimulated LH levels (0.56\u00b10.31 IU\/L), whereas 8% of ULH levels were above prepubertal threshold. Fourteen episodes of growth acceleration and ten episodes of BA advancement resolved without treatment modification.<\/jats:p><jats:p>Suppressed basal and post-GnRHa LH levels indicate adequate suppression of puberty. Clinical breakthroughs during treatment are transient and resolved spontaneously.<\/jats:p>","DOI":"10.1515\/jpem-2014-0478","type":"journal-article","created":{"date-parts":[[2015,7,13]],"date-time":"2015-07-13T08:57:51Z","timestamp":1436777871000},"source":"Crossref","is-referenced-by-count":8,"title":["Monitoring gonadotropin-releasing hormone analogue (GnRHa) treatment in girls with central precocious puberty: a comparison of four methods"],"prefix":"10.1515","volume":"28","author":[{"given":"Amnon","family":"Zung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Burundukov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira","family":"Ulman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Zadik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref421","first-page":"148","article-title":"PA Laboratory monitoring of children with precocious puberty Arch","author":"Lee","year":"1994","journal-title":"Med"},{"key":"ref511","article-title":"PA Treatment of central precocious puberty : comparison of urinary gonadotropin excretion and gonadotropin - releasing hormone stimulation tests in monitoring GnRH analog therapy","author":"Witchel","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref551","first-page":"107","article-title":"Clinical longitudinal standards for height and height velocity for North children","volume":"29","author":"Tanner","year":"1985","journal-title":"PS American J Pediatr"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"ref471","article-title":"Random unstimulated pediatric luteinizing hormone levels are not reliable in the assessment of pubertal suppression during histrelin implant therapy","volume":"20","author":"Neely EK","year":"2013","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref641","first-page":"0172","article-title":"Practical considerations for the treatment of central precocious puberty with a - month depot leuprolide acetate formulation Abstract th international congress of endocrinology th endocrine society annual meeting","volume":"16","author":"Lee","year":"2014"},{"key":"ref611","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders : comparison with the gonadotropin - releasing hormone test","volume":"78","author":"Ibanez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref81","first-page":"109","article-title":"DM Serum luteinizing hormone rises within minutes after depot leuprolide injection : implications for monitoring therapy","volume":"30","author":"Bhatia","year":"2002","journal-title":"Pediatrics"},{"key":"ref271","first-page":"149","article-title":"The human chorionic gonadotropin test is more powerful than the gonadotropin - releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty","volume":"23","author":"Degros","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"ref21","first-page":"270","article-title":"de Drop and biochemical evaluation of pubertal suppression with the GnRH agonist leuprolide acetate in early and precocious puberty","author":"Muinck Keizer","year":"1999","journal-title":"Horm Res"},{"key":"ref71","first-page":"148","article-title":"PA Laboratory monitoring of children with precocious puberty Arch","author":"Lee","year":"1994","journal-title":"Med"},{"key":"ref281","first-page":"127","article-title":"Normal ranges for immunochemiluminometric gonadotropin assays","volume":"40","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"ref381","first-page":"132","article-title":"Treatment of central precocious puberty with depot leuprorelin Leuprorelin Trial Group","author":"Carel","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"ref321","first-page":"2963","article-title":"Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty","author":"Demir","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/beem.2002.0188","article-title":"WG Treatment of central precocious puberty","volume":"16","author":"Partsch","year":"2002","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/jcem-62-4-670","article-title":"Long term treatment of male and female precocious puberty by periodic administration of a long - acting preparation of luteinizing hormone - releasing hormone microcapsules","volume":"7","author":"Roger","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"ref661","article-title":"Assessment of depot leuprolide acetate dose - adequacy for central precocious puberty","author":"Cook","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/398639","article-title":"Leuprolide acetate month depot for central precocious puberty : hormonal suppression and recovery Article ID","author":"Neely","year":"2011","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref111","first-page":"127","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","author":"Neely EK","year":"1995","journal-title":"J Pediatr"},{"key":"ref631","first-page":"127","article-title":"Normal ranges for immunochemiluminometric gonadotropin assays","volume":"40","author":"Neely","year":"1995","journal-title":"J Pediatr"},{"key":"ref581","article-title":"Assessment of basal and gonadotropin - releasing hormone - stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","author":"Resensde","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","first-page":"1","article-title":"and pharmacodynamics of agonists clinical implications in","volume":"13","author":"Lahlou","year":"2000","journal-title":"Pharmacokinetics pediatrics J Pediatr Endocrinol Metab"},{"key":"ref231","article-title":"Assessment of basal and gonadotropin - releasing hormone - stimulated gonadotropins by immunochemiluminometric and immunofluorometric assays in normal children","author":"Resensde","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref91","doi-asserted-by":"crossref","DOI":"10.1542\/peds.104.S5.1036","article-title":"DM Regular monitoring of bone age is not useful in children treated with growth hormone","author":"Wilson","year":"1999","journal-title":"Pediatrics"},{"key":"ref171","first-page":"170","article-title":"The diagnostic value of first - voided urinary LH compared with GNRH - stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls","author":"Zung","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"ref671","first-page":"2963","article-title":"Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty","author":"Demir","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref201","first-page":"107","article-title":"Clinical longitudinal standards for height and height velocity for North children","volume":"29","author":"Tanner","year":"1985","journal-title":"PS American J Pediatr"},{"key":"ref221","first-page":"3539","article-title":"Diagnostic value of fluorometric assays in the evaluation of precocious puberty","author":"Brito","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref61","first-page":"631","article-title":"Strich Triptorelin depot stimulation test for central precocious puberty","volume":"26","author":"Kvatinsky","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref561","article-title":"Radiographic atlas of skeletal development of the hand and wrist nd ed CA University","author":"Greulich","year":"1959"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/jcem-62-4-670","article-title":"Long term treatment of male and female precocious puberty by periodic administration of a long - acting preparation of luteinizing hormone - releasing hormone microcapsules","volume":"7","author":"Roger","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"ref521","first-page":"170","article-title":"The diagnostic value of first - voided urinary LH compared with GNRH - stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls","author":"Zung","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"ref31","first-page":"132","article-title":"Treatment of central precocious puberty with depot leuprorelin Leuprorelin Trial Group","author":"Carel","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"ref571","first-page":"3539","article-title":"Diagnostic value of fluorometric assays in the evaluation of precocious puberty","author":"Brito","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref371","first-page":"270","article-title":"de Drop and biochemical evaluation of pubertal suppression with the GnRH agonist leuprolide acetate in early and precocious puberty","author":"Muinck Keizer","year":"1999","journal-title":"Horm Res"},{"key":"ref651","first-page":"1","article-title":"randomized trial of - month depot leuprolide doses in the treatment of central precocious puberty","author":"Fuld","year":"2011","journal-title":"J Pediatr"},{"key":"ref401","first-page":"89","article-title":"single luteinizing hormone determination hours after depot leuprolide is useful for therapy monitoring of gonadotropin - dependent precocious puberty in girls","author":"Brito","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref301","first-page":"1","article-title":"randomized trial of - month depot leuprolide doses in the treatment of central precocious puberty","author":"Fuld","year":"2011","journal-title":"J Pediatr"},{"key":"ref441","doi-asserted-by":"crossref","DOI":"10.1542\/peds.104.S5.1036","article-title":"DM Regular monitoring of bone age is not useful in children treated with growth hormone","author":"Wilson","year":"1999","journal-title":"Pediatrics"},{"key":"ref151","first-page":"205","article-title":"Central precocious puberty : a single blood sample after gonadotropin - releasing hormone agonist administration in monitoring treatment","volume":"11","author":"Salerno","year":"1998","journal-title":"Horm Res"},{"key":"ref361","first-page":"1","article-title":"and pharmacodynamics of agonists clinical implications in","volume":"13","author":"Lahlou","year":"2000","journal-title":"Pharmacokinetics pediatrics J Pediatr Endocrinol Metab"},{"key":"ref621","first-page":"149","article-title":"The human chorionic gonadotropin test is more powerful than the gonadotropin - releasing hormone agonist test to discriminate male isolated hypogonadotropic hypogonadism from constitutional delayed puberty","volume":"23","author":"Degros","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"ref51","first-page":"89","article-title":"single luteinizing hormone determination hours after depot leuprolide is useful for therapy monitoring of gonadotropin - dependent precocious puberty in girls","author":"Brito","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref391","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/398639","article-title":"Leuprolide acetate month depot for central precocious puberty : hormonal suppression and recovery Article ID","author":"Neely","year":"2011","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref291","first-page":"0172","article-title":"Practical considerations for the treatment of central precocious puberty with a - month depot leuprolide acetate formulation Abstract th international congress of endocrinology th endocrine society annual meeting","volume":"16","author":"Lee","year":"2014"},{"key":"ref01","first-page":"123","article-title":"Consensus statement on the use of gonadotropin - releasing hormone analogs in children","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"ref351","first-page":"123","article-title":"Consensus statement on the use of gonadotropin - releasing hormone analogs in children","author":"Carel","year":"2009","journal-title":"Pediatrics"},{"key":"ref101","first-page":"123","article-title":"AR PA Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls","author":"Houk","year":"2009","journal-title":"Pediatrics"},{"key":"ref241","first-page":"704","article-title":"Efficacy and safety of histrelin subdermal implant in children with central precocious puberty : a multicenter trial","author":"Eugster","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref481","first-page":"162","article-title":"Random luteinizing hormone often remains pubertal in children treated with the histrelin implant for central precocious puberty","author":"Lewis","year":"2013","journal-title":"J Pediatr"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2605.2004.00487.x","article-title":"Bay Estradiol levels in prepubertal boys and girls analytical challenges","volume":"27","author":"Andersson","year":"2004","journal-title":"AM Int J Androl"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/beem.2002.0188","article-title":"WG Treatment of central precocious puberty","volume":"16","author":"Partsch","year":"2002","journal-title":"Pract Res Clin Endocrinol Metab"},{"key":"ref131","first-page":"162","article-title":"Random luteinizing hormone often remains pubertal in children treated with the histrelin implant for central precocious puberty","author":"Lewis","year":"2013","journal-title":"J Pediatr"},{"key":"ref451","first-page":"123","article-title":"AR PA Adequacy of a single unstimulated luteinizing hormone level to diagnose central precocious puberty in girls","author":"Houk","year":"2009","journal-title":"Pediatrics"},{"key":"ref211","article-title":"Radiographic atlas of skeletal development of the hand and wrist nd ed CA University","author":"Greulich","year":"1959"},{"key":"ref121","article-title":"Random unstimulated pediatric luteinizing hormone levels are not reliable in the assessment of pubertal suppression during histrelin implant therapy","volume":"20","author":"Neely EK","year":"2013","journal-title":"Int J Pediatr Endocrinol"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2605.2004.00487.x","article-title":"Bay Estradiol levels in prepubertal boys and girls analytical challenges","volume":"27","author":"Andersson","year":"2004","journal-title":"AM Int J Androl"},{"key":"ref411","first-page":"631","article-title":"Strich Triptorelin depot stimulation test for central precocious puberty","volume":"26","author":"Kvatinsky","year":"2013","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref261","article-title":"Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders : comparison with the gonadotropin - releasing hormone test","volume":"78","author":"Ibanez","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref461","first-page":"127","article-title":"Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty","author":"Neely EK","year":"1995","journal-title":"J Pediatr"},{"key":"ref191","first-page":"314","article-title":"CDC growth charts United States Data","author":"Kuczmarski","year":"2000"},{"key":"ref161","article-title":"PA Treatment of central precocious puberty : comparison of urinary gonadotropin excretion and gonadotropin - releasing hormone stimulation tests in monitoring GnRH analog therapy","author":"Witchel","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref541","first-page":"314","article-title":"CDC growth charts United States Data","author":"Kuczmarski","year":"2000"},{"key":"ref501","first-page":"205","article-title":"Central precocious puberty : a single blood sample after gonadotropin - releasing hormone agonist administration in monitoring treatment","volume":"11","author":"Salerno","year":"1998","journal-title":"Horm Res"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1136\/adc.44.235.291","article-title":"Variations in pattern of pubertal changes in girls","author":"Marshall","year":"1969","journal-title":"Arch Dis Child"},{"key":"ref311","article-title":"Assessment of depot leuprolide acetate dose - adequacy for central precocious puberty","author":"Cook","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref591","first-page":"704","article-title":"Efficacy and safety of histrelin subdermal implant in children with central precocious puberty : a multicenter trial","author":"Eugster","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref431","first-page":"109","article-title":"DM Serum luteinizing hormone rises within minutes after depot leuprolide injection : implications for monitoring therapy","volume":"30","author":"Bhatia","year":"2002","journal-title":"Pediatrics"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0478\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:27:48Z","timestamp":1652833668000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2014-0478\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":68,"journal-issue":{"issue":"7-8"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2014-0478","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}