{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:44:09Z","timestamp":1788821049779,"version":"build-2803163510"},"reference-count":116,"publisher":"Walter de Gruyter GmbH","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidemic of childhood obesity is associated with early atherosclerosis. Several reports have related this event to low-grade inflammation described in obesity. CRP and IL6 are markers that correlate with adiposity. The waist-to-height ratio (WtHR) is an anthropometric marker associated with insulin resistance and inflammation. The objective of this study was to assess the correlation between WtHR, metabolic complications and pro-inflammatory factors in obese children and adolescents.<\/jats:p><jats:p>Weight, height, waist circumference, glycemia, insulin, CRP, TNF-\u03b1 and IL-6 were measured in the baseline sample in 280 patients 6\u201319 years of age with overweight or obesity (OW\/OB) and 112 normal-weight controls. Logistic regression was performed using WtHR as an independent variable. p&gt;0.05 STATA11.<\/jats:p><jats:p>Mean WtHR was 0.6\u00b10.06 in OW\/OB and 0.43\u00b10.02 in controls (p&lt;0.01). WtHR was increased in 93% of the OW\/OB vs. 2% of the controls. In the OW\/OB inflammatory markers were significantly increased (p&lt;0.01) compared to the controls (CRP 2.2 vs. 0.8; Il-6 2.9 vs. 2.1; and TNF-\u03b1 6.2 vs. 5.5). In the WtHR&gt;0.5, insulin resistence and inflammatory markers were significantly increased (p&lt;0.01) compared to the WtHR&lt;0.5 (HOMA 3.4 vs. 1.4; CRP 2.3 vs. 0.6; Il-6 2.9 vs. 2.1; and TNF-\u03b1 6.4 vs. 5.55). In logistic regression, a significant independent association was found between WtHR with CRP (OR1.47), IL6 (OR1.60) and TNF-\u03b1 (OR1.79).<\/jats:p><jats:p>Obese children and adolescents have high inflammatory markers that may increase cardiovascular risk. WtHR is associated with low-grade inflammation and may be considered a relevant anthropometric marker in the clinical practice.<\/jats:p>","DOI":"10.1515\/jpem-2014-0526","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T14:05:33Z","timestamp":1455717933000},"source":"Crossref","is-referenced-by-count":26,"title":["Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents"],"prefix":"10.1515","volume":"29","author":[{"given":"Carolina","family":"Caminiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Armeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen 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