{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:32:06Z","timestamp":1762252326786,"version":"3.37.3"},"reference-count":72,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The widespread use of supplemental vitamin D has dramatically reduced the incidence of rickets. While generally considered a safe practice, there is potential for toxicity in patients with idiopathic infantile hypercalcemia (IIH). Inadequate 24-hydroxylase-enzyme activity renders these individuals unable to degrade active vitamin D, resulting in hypercalcemia due to increased intestinal calcium absorption, decreased renal calcium excretion, and increased osteoclastic bone activity. Clinicians should be aware that even therapeutic doses of vitamin D can prove harmful for patients with<\/jats:p>","DOI":"10.1515\/jpem-2015-0133","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T08:21:22Z","timestamp":1454660482000},"source":"Crossref","is-referenced-by-count":17,"title":["Idiopathic infantile hypercalcemia: case report and review of the literature"],"prefix":"10.1515","volume":"29","author":[{"given":"Brynn E.","family":"Marks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-8382","authenticated-orcid":false,"given":"Daniel A.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref561","first-page":"1","article-title":"The search for mutations in Canadian children : An unexpected presentation with nephrocalcinosis despite normal OH and serum calcium Poster session presented at Pediatric Academic Conference Vancouver","volume":"24","author":"Rousseau","year":"2014","journal-title":"Society"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1515\/jpem-2013-0229","article-title":"Importance of dietary calcium and vitamin D in the treatment of hypercalcemia in syndrome","volume":"27","author":"Lameris","year":"2014","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref741","article-title":"Comparison of low and high dose of vitamin treatment in nutritional vitamin deficiency","volume":"16","author":"Cesur","year":"2003","journal-title":"rickets J Pediatr Endocrinol Metab"},{"key":"ref721","first-page":"125","article-title":"Single - 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