{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T18:07:43Z","timestamp":1750874863220},"reference-count":44,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have suggested that triglyceride to HDL-cholesterol ratio (TRG\/HDL) is a surrogate marker of insulin resistance (IR), but information regarding its use in pediatric patients is limited. This study investigated the ability of TRG\/HDL ratio to assess IR in obese and overweight children.<\/jats:p><jats:p>The sample consisted of de-identified electronic medical records of patients aged 10\u201317 years (n=223). Logistic regression was performed using TRG\/HDL ratio as a predictor of hyperinsulinemia or IR defined using homeostasis model assessment score.<\/jats:p><jats:p>TRG\/HDL ratio had limited ability to predict hyperinsulinemia (AUROC 0.71) or IR (AUROC 0.72). Although females had higher insulin levels, male patients were significantly more likely to have hypertriglyceridemia and impaired fasting glucose.<\/jats:p><jats:p>TRG\/HDL ratio was not adequate for predicting IR in this population. Gender differences in the development of obesity-related metabolic abnormalities may impact the choice of screening studies in pediatric patients.<\/jats:p>","DOI":"10.1515\/jpem-2015-0158","type":"journal-article","created":{"date-parts":[[2015,8,14]],"date-time":"2015-08-14T20:14:44Z","timestamp":1439583284000},"source":"Crossref","is-referenced-by-count":7,"title":["Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia"],"prefix":"10.1515","volume":"29","author":[{"given":"Kristie Grove","family":"Bridges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Traci","family":"Jarrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Thorpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Baus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Cochran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref131","first-page":"120","article-title":"Expert committee recommendations regarding the prevention assessment and treatment of child and adolescent overweight and obesity : summary report","author":"Barlow","year":"2007","journal-title":"Pediatrics"},{"key":"ref251","first-page":"95","article-title":"Insulin resistance in children consensus perspective and future directions","author":"Levy","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1194\/jlr.M040584","article-title":"Plasma triglyceride cholesterol ratio insulin resistance and cardiometabolic risk in young adults","author":"Murgu\u00eda","year":"2013","journal-title":"J Lipid Res"},{"key":"ref451","first-page":"1","article-title":"Normal ages of pubertal events among American males and females Care","volume":"26","author":"Lee","year":"1980","journal-title":"Health"},{"key":"ref341","article-title":"The triglyceride to HDL ratio and its relationship to insulin resistance in pre - 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