{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:10:19Z","timestamp":1790770219862,"version":"4.1.0"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prepubertal gynecomastia is a rare condition characterized by the growth of breast tissue in males as a consequence of early exposure to sexual hormones. When this condition is present, pathological sources of testosterone\/estrogen production, such as adrenal or gonadal tumors must be searched for. A few reports have described an association between gynecomastia and substances that produce stimulation of the estrogen receptor, such as lavender and tea tree oil.<\/jats:p>\n                  <jats:p>Here we describe the cases of three boys who presented with prepubertal gynecomastia and were chronically exposed to lavender. Two of these boys were exposed to a cologne, named<\/jats:p>\n                  <jats:p>We studied a sample of the cologne used by one of the patients. Analysis of the chemical composition of the<\/jats:p>\n                  <jats:p>Exposure to estrogenic substances, such as lavender, should be explored in children presenting with prepubertal gynecomastia\/thelarche.<\/jats:p>","DOI":"10.1515\/jpem-2015-0248","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T13:03:46Z","timestamp":1441285426000},"source":"Crossref","is-referenced-by-count":34,"title":["Prepubertal gynecomastia and chronic lavender exposure: report of three cases"],"prefix":"10.1515","volume":"29","author":[{"given":"Alejandro","family":"Diaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Badar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kornic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Danon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref91","first-page":"328","author":"Braunstein","year":"1993","journal-title":"Engl J Med"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.2004.02059.x","article-title":"Klipper gynaecomastia aetilogy course outcome","volume":"61","author":"Einav","year":"2004","journal-title":"Clin Endocrinol"},{"key":"ref21","first-page":"71","article-title":"its features when and how to treat it","author":"Bembo","year":"2004","journal-title":"Clin J Med"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4158\/EP.9.5.370","article-title":"Epidemic of gynecomastia among Haitians refugees : exposure to an environmental antiandrogen","author":"Brody","year":"2003","journal-title":"Endocr Pract"},{"key":"ref181","first-page":"167","article-title":"Non - classical hydroxylase deficiency in boys with prepubertal or pubertal gynecomastia","volume":"21","author":"Wasniewska","year":"2008","journal-title":"Eur J Pediatr"},{"key":"ref251","first-page":"344","article-title":"- induced gynecomastia in children and adolescents","author":"Goldman","year":"2010","journal-title":"Drug Can Fam Physician"},{"key":"ref171","first-page":"71","article-title":"its features when and how to treat it","author":"Bembo","year":"2004","journal-title":"Clin J Med"},{"key":"ref121","first-page":"299","article-title":"and gonadal dysfunction in adolescent boys treated with a combination chemotherapy for Hodgkin s disease","volume":"12","author":"Sherings","year":"1978","journal-title":"Engl J Med"},{"key":"ref131","article-title":"Tea tree and lavender not linked to gynecomastia http roberttisserand com publications general articles Published Accessed on","volume":"13","author":"Robert Tisserand","year":"2008"},{"key":"ref201","first-page":"356","article-title":"Prepubertal gynecomastia linked to lavender and tea tree oils","author":"Henley","year":"2007","journal-title":"Engl J Med"},{"key":"ref61","first-page":"400","article-title":"FC Application of high - performance liquid chromatography diode array detection and mass spectrometry to the analysis of characteristic compounds in various essential oils","volume":"23","author":"Turek","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"ref81","first-page":"23","article-title":"angustifolia lavender Holist","author":"Stoltz","year":"2009","journal-title":"English"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4158\/EP.9.5.370","article-title":"Epidemic of gynecomastia among Haitians refugees : exposure to an environmental antiandrogen","author":"Brody","year":"2003","journal-title":"Endocr Pract"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/0009922806294800","article-title":"evaluation and treatment recommendations for primary care providers","author":"Cakan","year":"2007","journal-title":"Clin Pediatr"},{"key":"ref271","first-page":"299","article-title":"and gonadal dysfunction in adolescent boys treated with a combination chemotherapy for Hodgkin s disease","volume":"12","author":"Sherings","year":"1978","journal-title":"Engl J Med"},{"key":"ref31","first-page":"167","article-title":"Non - classical hydroxylase deficiency in boys with prepubertal or pubertal gynecomastia","volume":"21","author":"Wasniewska","year":"2008","journal-title":"Eur J Pediatr"},{"key":"ref101","first-page":"344","article-title":"- induced gynecomastia in children and adolescents","author":"Goldman","year":"2010","journal-title":"Drug Can Fam Physician"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.2004.02059.x","article-title":"Klipper gynaecomastia aetilogy course outcome","volume":"61","author":"Einav","year":"2004","journal-title":"Clin Endocrinol"},{"key":"ref241","first-page":"328","author":"Braunstein","year":"1993","journal-title":"Engl J Med"},{"key":"ref231","first-page":"23","article-title":"angustifolia lavender Holist","author":"Stoltz","year":"2009","journal-title":"English"},{"key":"ref211","first-page":"400","article-title":"FC Application of high - performance liquid chromatography diode array detection and mass spectrometry to the analysis of characteristic compounds in various essential oils","volume":"23","author":"Turek","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"ref51","first-page":"356","article-title":"Prepubertal gynecomastia linked to lavender and tea tree oils","author":"Henley","year":"2007","journal-title":"Engl J Med"},{"key":"ref281","article-title":"Tea tree and lavender not linked to gynecomastia http roberttisserand com publications general articles Published Accessed on","volume":"13","author":"Robert Tisserand","year":"2008"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/0009922806294800","article-title":"evaluation and treatment recommendations for primary care providers","author":"Cakan","year":"2007","journal-title":"Clin Pediatr"}],"container-title":["Journal of Pediatric Endocrinology and Metabolism"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0248\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:39:37Z","timestamp":1619041177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/jpem-2015-0248\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":24,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/jpem-2015-0248","relation":{},"ISSN":["2191-0251","0334-018X"],"issn-type":[{"value":"2191-0251","type":"electronic"},{"value":"0334-018X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}