{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T23:19:03Z","timestamp":1771715943964,"version":"3.50.1"},"reference-count":66,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to evaluate the etiology, the role of pubertal timing and most useful criteria for diagnostic workup in adolescents with growth failure.<\/jats:p><jats:p>Adolescents (n=182) aged 10.0\u201318.0 years underwent a standardized diagnostic protocol. Constitutional delay of growth and puberty (CDGP) was defined as late pubertal onset or a Tanner stage less than \u20132 SDS. Dutch and Finnish criteria for growth monitoring were retrospectively assessed.<\/jats:p><jats:p>In 13 children (7.1%) a specific diagnosis could be established. CDGP was diagnosed in 10% of patients aged \u226513 (girls) or \u226514 years (boys). Sensitivity to detect pathologic causes was 85% and 62% for, respectively Dutch and Finnish criteria for growth monitoring as used in younger children, but specificity was low (55%\u201359%).<\/jats:p><jats:p>In adolescents, pathological causes for growth failure and pubertal delay are common, and we recommend a combination of height SDS, distance to THSDS and growth deflection for deciding on further diagnostic testing.<\/jats:p>","DOI":"10.1515\/jpem-2015-0267","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:04:16Z","timestamp":1452816256000},"source":"Crossref","is-referenced-by-count":12,"title":["Growth failure in adolescents: etiology, the role of pubertal timing and most useful criteria for diagnostic workup"],"prefix":"10.1515","volume":"29","author":[{"given":"Susanne E.","family":"Stalman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilse","family":"Hellinga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan M.","family":"Wit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul C.M.","family":"Hennekam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerdine A.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans B.","family":"Pl\u00f6tz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2431-8-21","article-title":"The diagnostic work up of growth failure in secondary health care; an evaluation of consensus guidelines","volume":"8","year":"2008","journal-title":"BMC Pediatr"},{"key":"ref521","year":"2013","journal-title":"TNO Growth Calculator"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMcp1109290","article-title":"Clinical practice. 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